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In this review, we discuss modularity and hierarchy in biological systems. We review examples from protein structure, genetics, and biological networks of modular partitioning of the geometry of biological space. We review theories to…

Populations and Evolution · Quantitative Biology 2015-06-04 Dirk M. Lorenz , Alice Jeng , Michael W. Deem

We investigate the trade-off between the robustness against random and targeted removal of nodes from a network. To this end we utilize the stochastic block model to study ensembles of infinitely large networks with arbitrary large-scale…

Networking and Internet Architecture · Computer Science 2019-10-03 Christopher Priester , Sebastian Schmitt , Tiago P. Peixoto

Networks play a prominent role in the study of complex systems of interacting entities in biology, sociology, and economics. Despite this diversity, we demonstrate here that a statistical model decomposing networks into matching and…

Physics and Society · Physics 2016-02-05 Rudolf P. Rohr , Russel E. Naisbit , Christian Mazza , Louix-Félix Bersier

Networks have in recent years emerged as an invaluable tool for describing and quantifying complex systems in many branches of science. Recent studies suggest that networks often exhibit hierarchical organization, where vertices divide into…

Machine Learning · Statistics 2008-11-05 Aaron Clauset , Cristopher Moore , M. E. J. Newman

We model the robustness against random failure or intentional attack of networks with arbitrary large-scale structure. We construct a block-based model which incorporates --- in a general fashion --- both connectivity and interdependence…

Physics and Society · Physics 2012-09-25 Tiago P. Peixoto , Stefan Bornholdt

The roles of different nodes within a network are often understood through centrality analysis, which aims to quantify the capacity of a node to influence, or be influenced by, other nodes via its connection topology. Many different…

Social and Information Networks · Computer Science 2020-07-01 Stuart Oldham , Ben Fulcher , Linden Parkes , Aurina Arnatkeviciute , Chao Suo , Alex Fornito

[Background] Several studies have mentioned network modularity -- that a network can easily be decomposed into subgraphs that are densely connected within and weakly connected between each other -- as a factor affecting metabolic…

Molecular Networks · Quantitative Biology 2012-10-10 Petter Holme

This work targets the influence of disorder on the relaxed structure and macroscopic mechanical properties of elastic networks. We construct network classes of different types of disorder (length, topology and stiffness), which are…

Soft Condensed Matter · Physics 2025-08-29 Stefanie Heyden , Mohit Pundir , Eric R. Dufresne , David S. Kammer

Interactions between units in phyical, biological, technological, and social systems usually give rise to intrincate networks with non-trivial structure, which critically affects the dynamics and properties of the system. The focus of most…

Data Analysis, Statistics and Probability · Physics 2007-05-23 R. Guimera , M. Sales-Pardo , L. A. N. Amaral

Complex networks are usually characterized in terms of their topological, spatial, or information-theoretic properties and combinations of the associated metrics are used to discriminate networks into different classes or categories.…

Data Analysis, Statistics and Probability · Physics 2017-10-25 Marc Wiedermann , Jonathan F. Donges , Jürgen Kurths , Reik V. Donner

Empirical complex systems can be characterized not only by pairwise interactions, but also by higher-order (group) interactions influencing collective phenomena, from metabolic reactions to epidemics. Nevertheless, higher-order networks'…

Physics and Society · Physics 2026-01-01 Maxime Lucas , Luca Gallo , Arsham Ghavasieh , Federico Battiston , Manlio De Domenico

The modular structure of brain networks supports specialized information processing, complex dynamics, and cost-efficient spatial embedding. Inter-individual variation in modular structure has been linked to differences in performance,…

Core-periphery structure, the arrangement of a network into a dense core and sparse periphery, is a versatile descriptor of various social, biological, and technological networks. In practice, different core-periphery algorithms are often…

Social and Information Networks · Computer Science 2021-04-23 Ryan J. Gallagher , Jean-Gabriel Young , Brooke Foucault Welles

We focus on the detection of communities in multi-scale networks, namely networks made of different levels of organization and in which modules exist at different scales. It is first shown that methods based on modularity are not…

Physics and Society · Physics 2010-09-14 Renaud Lambiotte

Modular structure is ubiquitous among real-world networks from related proteins to social groups. Here we analyze the modular organization of brain networks at a large-scale (voxel level) extracted from functional magnetic resonance imaging…

Data Analysis, Statistics and Probability · Physics 2009-04-16 M. Valencia , M. A. Pastor , MA. Fernandez-Seara , J. Artieda , J. Martinerie , M. Chavez

Interconnected networks describe the dynamics of important systems in a wide range such as biological systems and electrical power grids. Some important features of these systems were successfully studied and understood through simplified…

Systems and Control · Computer Science 2016-03-18 Thanh Long Vu , Konstantin Turitsyn

Mutualistic networks have been shown to involve complex patterns of interactions among animal and plant species. The architecture of these webs seems to pervade some of their robust and fragile behaviour. Recent work indicates that there is…

Populations and Evolution · Quantitative Biology 2016-12-07 Sergi Valverde , Jose Montoya , Lucas Joppa , Ricard Sole

Heterogeneous and complex networks represent intertwined interactions between real-world elements or agents. Determining the multi-scale mesoscopic organization of clusters and intertwined structures is still a fundamental and open problem…

Physics and Society · Physics 2025-01-20 Pablo Villegas , Andrea Gabrielli , Anna Poggialini , Tommaso Gili

Modularity is a key organizing principle in real-world large-scale complex networks. Many real-world networks exhibit modular structures such as transportation infrastructures, communication networks and social media. Having the knowledge…

Physics and Society · Physics 2020-02-26 Eitan Asher , Hillel Sanhedrai , Nagendra K. Panduranga , Reuven Cohen , Shlomo Havlin

Brain functions require both segregated processing of information in specialized circuits, as well as integration across circuits to perform high-level information processing. One possible way to implement these seemingly opposing demands…

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