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We investigate the translocation of a stiff polymer through a nanopore in a membrane, in the presence of binding particles (chaperones) that bind reversibly to the polymer on both sides of the membrane. A bound chaperone covers one…

Statistical Mechanics · Physics 2016-08-16 Tobias Ambjörnsson , Ralf Metzler

We study the translocation of polymers across varying-section channels. Using systematic approximations, we derive a simplified model that reduces the problem of polymer translocation through varying-section channels to that of a point-like…

Soft Condensed Matter · Physics 2017-07-13 Valentino Bianco , Paolo Malgaretti

Ionic Coulomb blockade in nanopores is a phenomenon that shares some similarities but also differences with its electronic counterpart. Here, we investigate extensively this phenomenon using all-atom molecular dynamics of ionic transport…

Mesoscale and Nanoscale Physics · Physics 2017-12-27 Hiroya Tanaka , Hideo Iizuka , Yuriy V. Pershin , Massimiliano Di Ventra

We consider the flow-driven translocation of single polymer chains through nanochannels. Using analytical calculations based on the de Gennes blob model and mesoscopic numerical simulations, we estimate the threshold flux for the…

Soft Condensed Matter · Physics 2011-10-26 Rodrigo Ledesma-Aguilar , Takahiro Sakaue , Julia M. Yeomans

Large-scale molecular dynamics simulations are used to simulate a layer of nanoparticles diffusing on the surface of a liquid. Both a low viscosity liquid, represented by Lennard-Jones monomers, and a high viscosity liquid, represented by…

Soft Condensed Matter · Physics 2013-01-10 Shengfeng Cheng , Gary S. Grest

We investigate the translocation dynamics of heteropolymers driven through a nanopore using a constant temperature Langevin thermostat. Specifically, we consider heteropolymers consisting of two types of monomers labeled A and B, which are…

Soft Condensed Matter · Physics 2007-05-23 Kaifu Luo , Tapio Ala-Nissila , See-Chen Ying , Aniket Bhattacharya

We study the dynamics of an ideal polymer chain in a crowded, viscoelastic medium and in the presence of active forces. The motion of the centre of mass and of individual monomers is calculated. On time scales that are comparable to the…

Soft Condensed Matter · Physics 2015-12-23 Hans Vandebroek , Carlo Vanderzande

Recent studies have suggested that the Nuclear Pore Complex (NPC) plays a significant role in mechanotransduction. When a force is exerted, the NPC's diameter widens, leading to an increased molecular flux into the nucleus. In this study,…

Biological Physics · Physics 2025-04-09 Atsushi Matsuda , Mohammad R. K. Mofrad

Active polymer translocation through confined spaces is a key biological process underlying DNA transport through nuclear pores and actin filament dynamics in cell migration. Here, we use living polymer-like Tubifex tubifex worms as a model…

Soft Condensed Matter · Physics 2025-04-28 Marin Vatin , Rosa Sinaasappel , Renske Kamping , Chantal Valeriani , Emanuele Locatelli , Antoine Deblais

We present a detailed description of biopolymer translocation through a nanopore in the presence of a solvent, using an innovative multi-scale methodology which treats the biopolymer at the microscopic scale as combined with a…

Computational Physics · Physics 2008-02-27 Massimo Bernaschi , Simone Melchionna , Sauro Succi , Maria Fyta , Efthimios Kaxiras

Here we report on the translocation of folded polymers through nano-pores using molecular dynamic simulations. Two cases are studied; one in which a folded molecule unfolds upon passage and one in which the folding remains intact as the…

Soft Condensed Matter · Physics 2016-03-23 Narges Nikoofard , Alireza Mashaghi

We develop a correlation-corrected transport theory in order to predict ionic and polymer transport properties of membrane nanopores in physical conditions where mean-field electrostatics breaks down. The experimentally observed low KCl…

Soft Condensed Matter · Physics 2014-11-06 Sahin Buyukdagli , Tapio Ala-Nissila

Adsorption of polymers to surfaces is crucial for understanding many fundamental processes in nature. Recent experimental studies indicate that the adsorption dynamics is dominated by non-equilibrium effects. We investigate the adsorption…

Soft Condensed Matter · Physics 2009-05-12 Debabrata Panja , Gerard T. Barkema , Anatoly B. Kolomeisky

Processes on different length scales affect the dynamics of chain molecules. In this work, we focus on structures on the scale of a monomer and investigate polyolefins, i.e. hydrocarbon chains with different small scale architectures. We…

Soft Condensed Matter · Physics 2009-10-31 Jutta Luettmer-Strathmann

A multiscale approach is used to simulate the translocation of DNA through a nanopore. Within this scheme, the interactions of the molecule with the surrounding fluid (solvent) are explicitly taken into account. By generating polymers of…

Biological Physics · Physics 2009-11-13 Simone Melchionna , Maria Fyta , Efthimios Kaxiras , Sauro Succi

Using continuous time Monte-Carlo method we simulated the translocation of a polynucleotide chain driven through a nanopore by an electric field. We have used two models of driven diffusion due to the electric field. The chain may have…

Soft Condensed Matter · Physics 2009-11-11 Pui-Man Lam , Fei Liu , Zhong-can OuYang

We study the propagation of tension caused by an external force along a long polymeric molecule in two different settings, namely along a free polymer in 3d space being pulled from one end, and along a pre-stretched circular polymer,…

Soft Condensed Matter · Physics 2013-06-20 Payam Rowghanian , Alexander Y. Grosberg

The transport of deformable particles through porous media underlies a wealth of applications ranging from filtration to oil recovery to the transport and spreading of biological agents. Using direct numerical simulations, we analyze the…

Soft Condensed Matter · Physics 2020-06-09 Brato Chakrabarti , Charles Gaillard , David Saintillan

We investigate the dynamics of DNA translocation through a nanopore driven by an external force using Langevin dynamics simulations in two dimensions (2D) to study how the translocation dynamics depend on the details of the DNA sequences.…

Soft Condensed Matter · Physics 2008-12-09 Kaifu Luo , Tapio Ala-Nissila , See-Chen Ying , Aniket Bhattacharya

We investigate the dynamics of nanoparticles in semidilute polymer solutions when the nanoparticles are comparably sized to the polymer coils using explicit- and implicit-solvent simulation methods. The nanoparticle dynamics are…