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Given that the neural and connective tissues of the optic nerve head (ONH) exhibit complex morphological changes with the development and progression of glaucoma, their simultaneous isolation from optical coherence tomography (OCT) images…

Diabetic retinopathy (DR) is the most common form of diabetic eye disease. Retinopathy can affect all diabetic patients and becomes particularly dangerous, increasing the risk of blindness, if it is left untreated. The success rate of its…

Computer Vision and Pattern Recognition · Computer Science 2019-02-11 Oindrila Saha , Rachana Sathish , Debdoot Sheet

Objective: To develop an explainable multimodal large language model (MM-LLM) that (1) screens optic nerve head (ONH) OCT circle scans for quality and (2) generates structured clinical reports that include glaucoma diagnosis and sector-wise…

Multiple-surface segmentation in Optical Coherence Tomography (OCT) images is a challenge problem, further complicated by the frequent presence of weak image boundaries. Recently, many deep learning (DL) based methods have been developed…

Image and Video Processing · Electrical Eng. & Systems 2022-10-13 Hui Xie , Weiyu Xu , Xiaodong Wu

Fundus photography (FP) remains the primary imaging modality in screening various retinal diseases including age-related macular degeneration, diabetic retinopathy and glaucoma. FP allows the clinician to examine the ocular fundus…

Image and Video Processing · Electrical Eng. & Systems 2023-02-21 Shanmukh Reddy Manne , Jose-Alain Sahel , Jay Chhablani , Kiran Kumar Vupparaboinab , Soumya Jana

The estimation of glaucoma progression is a challenging task as the rate of disease progression varies among individuals in addition to other factors such as measurement variability and the lack of standardization in defining progression.…

Glaucoma causes irreversible vision loss due to damage to the optic nerve, and there is no cure for glaucoma.OCT imaging modality is an essential technique for assessing glaucomatous damage since it aids in quantifying fundus structures. To…

Computer Vision and Pattern Recognition · Computer Science 2022-08-01 Huihui Fang , Fei Li , Huazhu Fu , Junde Wu , Xiulan Zhang , Yanwu Xu

Optical coherence tomography (OCT) is a non-invasive imaging technique with extensive clinical applications in ophthalmology. OCT enables the visualization of the retinal layers, playing a vital role in the early detection and monitoring of…

Purpose: To investigate the impact of optic nerve tortuosity (ONT), and the interaction of globe proptosis and globe size on retinal ganglion cell (RGC) thickness, using Retinal Nerve Fiber Layer (RNFL) thickness, across general, glaucoma,…

Color fundus photography and Optical Coherence Tomography (OCT) are the two most cost-effective tools for glaucoma screening. Both two modalities of images have prominent biomarkers to indicate glaucoma suspected. Clinically, it is often…

The task of automatically segmenting 3-D surfaces representing boundaries of objects is important for quantitative analysis of volumetric images, and plays a vital role in biomedical image analysis. Recently, graph-based methods with a…

Computer Vision and Pattern Recognition · Computer Science 2018-01-10 Abhay Shah , Michael Abramoff , Xiaodong Wu

Diabetic retinopathy (DR) is a leading cause of vision loss, requiring early and accurate assessment to prevent irreversible damage. Spectral Domain Optical Coherence Tomography (SD-OCT) enables high-resolution retinal imaging, but…

Image and Video Processing · Electrical Eng. & Systems 2025-07-15 S. Chen , D. Ma , M. Raviselvan , S. Sundaramoorthy , K. Popuri , M. J. Ju , M. V. Sarunic , D. Ratra , M. F. Beg

Machine learning is gaining significant attention as a diagnostic tool in medical imaging, particularly in the analysis of retinal fundus images. However, this approach is not yet clinically applicable, as it still depends on human…

Human-Computer Interaction · Computer Science 2025-10-03 Mattea Reid , Zuhairah Zainal , Khaing Zin Than , Danielle Chan , Jonathan Chan

Diabetic retinopathy (DR) grading from fundus images has attracted increasing interest in both academic and industrial communities. Most convolutional neural network (CNN) based algorithms treat DR grading as a classification task via…

Computer Vision and Pattern Recognition · Computer Science 2021-03-19 Yehui Yang , Fangxin Shang , Binghong Wu , Dalu Yang , Lei Wang , Yanwu Xu , Wensheng Zhang , Tianzhu Zhang

Optical Coherence Tomography (OCT) provides valuable insights in ophthalmology, cardiology, and neurology due to high-resolution, cross-sectional images of the retina. One critical task for ophthalmologists using OCT is delineation of…

Image and Video Processing · Electrical Eng. & Systems 2025-05-21 Samuel T. M. Ball

Scarcity of large publicly available retinal fundus image datasets for automated glaucoma detection has been the bottleneck for successful application of artificial intelligence towards practical Computer-Aided Diagnosis (CAD). A few small…

Image and Video Processing · Electrical Eng. & Systems 2020-06-17 Muhammad Naseer Bajwa , Gur Amrit Pal Singh , Wolfgang Neumeier , Muhammad Imran Malik , Andreas Dengel , Sheraz Ahmed

Optical coherence tomography (OCT) is being increasingly adopted as a label-free and non-invasive technique for biomedical applications such as cancer and ocular disease diagnosis. Diagnostic information for these tissues is manifest in…

Purpose: (1) To develop a deep learning algorithm to identify major tissue structures of the optic nerve head (ONH) in 3D optical coherence tomography (OCT) scans; (2) to exploit such information to robustly differentiate among healthy,…

Optical Coherence Tomography (OCT) is a novel and effective screening tool for ophthalmic examination. Since collecting OCT images is relatively more expensive than fundus photographs, existing methods use multi-modal learning to complement…

Image and Video Processing · Electrical Eng. & Systems 2023-08-02 Lehan Wang , Weihang Dai , Mei Jin , Chubin Ou , Xiaomeng Li

To analyze this characteristic of vulnerability, we developed an automated deep learning method for detecting microvessels in intravascular optical coherence tomography (IVOCT) images. A total of 8,403 IVOCT image frames from 85 lesions and…