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Approximate Bayesian Computation (ABC) is typically used when the likelihood is either unavailable or intractable but where data can be simulated under different parameter settings using a forward model. Despite the recent interest in ABC,…

Methodology · Statistics 2019-12-24 Rafael Izbicki , Ann B. Lee , Taylor Pospisil

This study applied Bayesian optimization likelihood-free inference(BOLFI) to virus dynamics experimental data and efficiently inferred the model parameters with uncertainty measure. The computational benefit is remarkable compared to…

Applications · Statistics 2025-09-11 Yingying Xu

Likelihood-free approaches are appealing for performing inference on complex dependence models, either because it is not possible to formulate a likelihood function, or its evaluation is very computationally costly. This is the case for…

Methodology · Statistics 2025-12-08 Lídia M. André , Jennifer L. Wadsworth , Raphaël Huser

Mechanistic dynamic models of biochemical networks such as Ordinary Differential Equations (ODEs) contain unknown parameters like the reaction rate constants and the initial concentrations of the compounds. The large number of parameters as…

Data Analysis, Statistics and Probability · Physics 2017-08-14 Clemens Kreutz , Andreas Raue , Jens Timmer

Hierarchical models are versatile tools for joint modeling of data sets arising from different, but related, sources. Fully Bayesian inference may, however, become computationally prohibitive if the source-specific data models are complex,…

Computation · Statistics 2016-05-06 Ritabrata Dutta , Paul Blomstedt , Samuel Kaski

Modeling distributions of covariates, or density estimation, is a core challenge in unsupervised learning. However, the majority of work only considers the joint distribution, which has limited utility in practical situations. A more…

Machine Learning · Computer Science 2021-10-28 Ryan R. Strauss , Junier B. Oliva

We present a model-free data-driven inference method that enables inferences on system outcomes to be derived directly from empirical data without the need for intervening modeling of any type, be it modeling of a material law or modeling…

Functional Analysis · Mathematics 2021-06-08 Sergio Conti , Franca Hoffmann , Michael Ortiz

Regularized empirical risk minimization (rERM) has become important in data-intensive fields such as genomics and advertising, with stochastic gradient methods typically used to solve the largest problems. However, ill-conditioned…

Machine Learning · Statistics 2025-01-28 Jingruo Sun , Zachary Frangella , Madeleine Udell

Density ratio estimation (DRE) is a paramount task in machine learning, for its broad applications across multiple domains, such as covariate shift adaptation, causal inference, independence tests and beyond. Parametric methods for…

Machine Learning · Statistics 2025-06-03 Meilin Wang , Wei Huang , Mingming Gong , Zheng Zhang

ABC algorithms are notoriously expensive in computing time, as they require simulating many complete artificial datasets from the model. We advocate in this paper a "divide and conquer" approach to ABC, where we split the likelihood into n…

Computation · Statistics 2015-12-02 Simon Barthelmé , Nicolas Chopin , Vincent Cottet

Profile likelihood provides a general framework to infer on a scalar parameter of a statistical model. A confidence interval is obtained by numerically finding the two abscissas where the profile log-likelihood curve intersects an…

Computation · Statistics 2024-04-04 Yves Deville

In the following article we consider approximate Bayesian parameter inference for observation driven time series models. Such statistical models appear in a wide variety of applications, including econometrics and applied mathematics. This…

Computation · Statistics 2013-04-01 Ajay Jasra , Nikolas Kantas , Elena Ehrlich

Deep neural networks are one of the most successful classifiers across different domains. However, due to their limitations concerning interpretability their use is limited in safety critical context. The research field of explainable…

Machine Learning · Computer Science 2022-05-30 Dominique Mercier , Andreas Dengel , Sheraz Ahmed

Approximate Bayesian Computation (ABC) methods are applicable to statistical models specified by generative processes with analytically intractable likelihoods. These methods try to approximate the posterior density of a model parameter by…

Methodology · Statistics 2024-03-11 Sanjay Chaudhuri , Subhroshekhar Ghosh , Kim Cuc Pham

We discuss Bayesian inference for parameters selected using the data. First, we provide a critical analysis of the existing positions in the literature regarding the correct Bayesian approach under selection. Second, we propose two types of…

Statistics Theory · Mathematics 2021-05-12 Daniel G. Rasines , G. Alastair Young

Heterogeneity is a dominant factor in the behaviour of many biological processes. Despite this, it is common for mathematical and statistical analyses to ignore biological heterogeneity as a source of variability in experimental data.…

Many modern statistical applications involve inference for complicated stochastic models for which the likelihood function is difficult or even impossible to calculate, and hence conventional likelihood-based inferential echniques cannot be…

Computation · Statistics 2013-05-29 Simon R. White , Theodore Kypraios , Simon P. Preston

Implicit probabilistic models are a flexible class of models defined by a simulation process for data. They form the basis for theories which encompass our understanding of the physical world. Despite this fundamental nature, the use of…

Machine Learning · Statistics 2017-11-07 Dustin Tran , Rajesh Ranganath , David M. Blei

In robotics, likelihood-free inference (LFI) can provide the domain distribution that adapts a learnt agent in a parametric set of deployment conditions. LFI assumes an arbitrary support for sampling, which remains constant as the initial…

Robotics · Computer Science 2026-02-26 Georgios Kamaras , Craig Innes , Subramanian Ramamoorthy

Multi-fidelity (MF) regression often operates in regimes of extreme data imbalance, where the commonly-used Gaussian-process (GP) surrogates struggle with cubic scaling costs and overfit to sparse high-fidelity observations, limiting…

Machine Learning · Computer Science 2026-02-02 Rosen Ting-Ying Yu , Nicholas Sung , Faez Ahmed