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Machine learning has transformed the field of atomistic simulations by enabling the development of interatomic potentials that are computationally efficient and highly accurate. These advances have opened the door to modeling molecular…

Chemical Physics · Physics 2026-05-22 Nitik Bhatia , Ondrej Krejci , Patrick Rinke

Predicting missing links between entities in a knowledge graph is a fundamental task to deal with the incompleteness of data on the Web. Knowledge graph embeddings map nodes into a vector space to predict new links, scoring them according…

Artificial Intelligence · Computer Science 2023-02-14 Cosimo Gregucci , Mojtaba Nayyeri , Daniel Hernández , Steffen Staab

The widespread application of machine learning (ML) to the chemical sciences is making it very important to understand how the ML models learn to correlate chemical structures with their properties, and what can be done to improve the…

Molecule representation learning is crucial for understanding and predicting molecular properties. However, conventional atom-centric models, which treat chemical bonds merely as pairwise interactions, often overlook complex bond-level…

Machine Learning · Computer Science 2026-03-03 Yunqing Liu , Yi Zhou , Wenqi Fan

Message passing neural networks have become a method of choice for learning on graphs, in particular the prediction of chemical properties and the acceleration of molecular dynamics studies. While they readily scale to large training data…

Machine Learning · Computer Science 2021-06-08 Kristof T. Schütt , Oliver T. Unke , Michael Gastegger

An essential aspect for adequate predictions of chemical properties by machine learning models is the database used for training them. However, studies that analyze how the content and structure of the databases used for training impact the…

Chemical Physics · Physics 2023-09-29 Luis Itza Vazquez-Salazar , Eric Boittier , Oliver T. Unke , Markus Meuwly

Network theory provides a rich toolbox consisting of methods, measures, and models for studying the structure and dynamics of complex systems found in nature, society, or technology. Recently, it has been pointed out that many real-world…

Physics and Society · Physics 2016-04-07 Marc Wiedermann , Jonathan F. Donges , Jobst Heitzig , Jürgen Kurths

Engineering simulations for analysis of structural and fluid systems require information of contacts between various 3-D surfaces of the geometry to accurately model the physics between them. In machine learning applications, 3-D surfaces…

Machine Learning · Computer Science 2021-03-23 Rishikesh Ranade , Jay Pathak

Characterizing microstructure-material-property relations calls for software tools which extract point-cloud- and continuum-scale-based representations of microstructural objects. Application examples include atom probe, electron, and…

This paper deals with neural networks as dynamical systems governed by differential or difference equations. It shows that the introduction of skip connections into network architectures, such as residual networks and dense networks, turns…

Neural and Evolutionary Computing · Computer Science 2019-02-25 Michael Hauser , Sean Gunn , Samer Saab , Asok Ray

Accurate prediction of molecular properties in complex chemical systems is crucial for accelerating material discovery and chemical innovation. However, current computational methods often struggle to capture the intricate compositional…

Chemical Physics · Physics 2025-09-24 Jinming Fan , Chao Qian , Shaodong Zhou

Synthetic polymers are versatile and widely used materials. Similar to small organic molecules, a large chemical space of such materials is hypothetically accessible. Computational property prediction and virtual screening can accelerate…

Machine Learning · Computer Science 2022-10-13 Matteo Aldeghi , Connor W. Coley

Collective behaviors that emerge from interactions are fundamental to numerous biological systems. To learn such interacting forces from observations, we introduce a measure-valued neural network that infers measure-dependent interaction…

Numerical Analysis · Mathematics 2026-04-08 Liyao Lyu , Xinyue Yu , Hayden Schaeffer

What determines whether a molecular property prediction model organizes its representations so that geometric and compositional information can be cleanly separated? We introduce Compositional Probe Decomposition (CPD), which linearly…

Machine Learning · Computer Science 2026-03-10 Joshua Steier

At present, the vast majority of building blocks, techniques, and architectures for deep learning are based on real-valued operations and representations. However, recent work on recurrent neural networks and older fundamental theoretical…

Quantum machine learning (QML) has great potential for the analysis of chemical datasets. However, conventional quantum data-encoding schemes, such as fingerprint encoding, are generally unfeasible for the accurate representation of…

Quantum Physics · Physics 2025-11-18 Choy Boy , Edoardo Altamura , Dilhan Manawadu , Ivano Tavernelli , Stefano Mensa , David J. Wales

We introduce a composition-weighted symbolic regression framework for interpretable prediction of materials properties directly from chemical composition. The method jointly learns analytical functional forms and task-dependent elemental…

Materials Science · Physics 2026-05-05 Yang Huang , Jingrun Chen

Our work is motivated by and illustrated with application of association networks in computational biology, specifically in the context of gene/protein regulatory networks. Association networks represent systems of interacting elements,…

Applications · Statistics 2012-05-01 Natallia Katenka , Eric D. Kolaczyk

We analytically derive the geometrical structure of the weight space in multilayer neural networks (MLN), in terms of the volumes of couplings associated to the internal representations of the training set. Focusing on the parity and…

Condensed Matter · Physics 2016-08-31 R. Monasson , R. Zecchina

Accumulation of molecular data obtained from quantum mechanics (QM) theories such as density functional theory (DFTQM) make it possible for machine learning (ML) to accelerate the discovery of new molecules, drugs, and materials. Models…

Chemical Physics · Physics 2020-11-04 Alain B. Tchagang , Ahmed H. Tewfik , Julio J. Valdés