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Conventional survival analysis approaches estimate risk scores or individualized time-to-event distributions conditioned on covariates. In practice, there is often great population-level phenotypic heterogeneity, resulting from (unknown)…

Machine Learning · Statistics 2020-03-03 Paidamoyo Chapfuwa , Chunyuan Li , Nikhil Mehta , Lawrence Carin , Ricardo Henao

Despite the ubiquity of kernel-based clustering, surprisingly few statistical guarantees exist beyond settings that consider strong structural assumptions on the data generation process. In this work, we take a step towards bridging this…

Machine Learning · Computer Science 2021-10-19 Leena Chennuru Vankadara , Sebastian Bordt , Ulrike von Luxburg , Debarghya Ghoshdastidar

We develop here a semiparametric Gaussian mixture model (SGMM) for unsupervised learning with valuable spatial information taken into consideration. Specifically, we assume for each instance a random location. Then, conditional on this…

Methodology · Statistics 2025-10-21 Baichen Yu , Jin Liu , Hansheng Wang

We introduce a random partition model for Bayesian nonparametric regression. The model is based on infinitely-many disjoint regions of the range of a latent covariate-dependent Gaussian process. Given a realization of the process, the…

Methodology · Statistics 2013-01-04 George Karabatsos , Stephen G. Walker

The reconstruction of missing information in epidemic spreading on contact networks can be essential in the prevention and containment strategies. The identification and warning of infectious but asymptomatic individuals (i.e., contact…

Social and Information Networks · Computer Science 2022-11-21 Indaco Biazzo , Alfredo Braunstein , Luca Dall'Asta , Fabio Mazza

This paper proposes a computationally efficient Bayesian factor model for multiple grouped count data. Adopting the link function approach, the proposed model can capture the association within and between the at-risk probabilities and…

Methodology · Statistics 2024-05-13 Genya Kobayashi , Yuta Yamauchi

We introduce a novel profile-based patient clustering model designed for clinical data in healthcare. By utilizing a method grounded on constrained low-rank approximation, our model takes advantage of patients' clinical data and digital…

Machine Learning · Computer Science 2023-08-24 Dongjin Choi , Andy Xiang , Ozgur Ozturk , Deep Shrestha , Barry Drake , Hamid Haidarian , Faizan Javed , Haesun Park

Multivariate distributions often carry latent structures that are difficult to identify and estimate, and which better reflect the data generating mechanism than extrinsic structures exhibited simply by the raw data. In this paper, we…

Methodology · Statistics 2025-04-16 Bryon Aragam , Ruiyi Yang

Integrative analyses based on statistically relevant associations between genomics and a wealth of intermediary phenotypes (such as imaging) provide vital insights into their clinical relevance in terms of the disease mechanisms. Estimates…

Applications · Statistics 2022-08-16 Snigdha Panigrahi , Shariq Mohammed , Arvind Rao , Veerabhadran Baladandayuthapani

Motivated by the need to analyze continuously updated data sets in the context of time-to-event modeling, we propose a novel nonparametric approach to estimate the conditional hazard function given a set of continuous and discrete…

Methodology · Statistics 2025-07-03 Daphné Aurouet , Valentin Patilea

The relationship between inflation and predictors such as unemployment is potentially nonlinear with a strength that varies over time, and prediction errors error may be subject to large, asymmetric shocks. Inspired by these concerns, we…

Econometrics · Economics 2022-03-01 Todd E. Clark , Florian Huber , Gary Koop , Massimiliano Marcellino

High-throughput microarray and sequencing technology have been used to identify disease subtypes that could not be observed otherwise by using clinical variables alone. The classical unsupervised clustering strategy concerns primarily the…

Methodology · Statistics 2020-07-23 Peng Liu , Yusi Fang , Zhao Ren , Lu Tang , George C. Tseng

With the recent growth in data availability and complexity, and the associated outburst of elaborate modelling approaches, model selection tools have become a lifeline, providing objective criteria to deal with this increasingly challenging…

Methodology · Statistics 2020-10-08 Alessandro Casa , Luca Scrucca , Giovanna Menardi

Joint alignment of a collection of functions is the process of independently transforming the functions so that they appear more similar to each other. Typically, such unsupervised alignment algorithms fail when presented with complex data…

Machine Learning · Computer Science 2012-10-19 Marwan A. Mattar , Allen R. Hanson , Erik G. Learned-Miller

Bayesian models offer great flexibility for clustering applications---Bayesian nonparametrics can be used for modeling infinite mixtures, and hierarchical Bayesian models can be utilized for sharing clusters across multiple data sets. For…

Machine Learning · Computer Science 2012-06-15 Brian Kulis , Michael I. Jordan

We introduce a novel Bayesian estimator for the class proportion in an unlabeled dataset, based on the targeted learning framework. Our procedure requires the specification of a prior (and outputs a posterior) only for the target of…

Methodology · Statistics 2019-11-26 Iván Díaz , Oleksander Savenkov , Hooman Kamel

Network models provide a powerful framework for analysing single-cell count data, facilitating the characterisation of cellular identities, disease mechanisms, and developmental trajectories. However, uncertainty modeling in unsupervised…

Genomics · Quantitative Biology 2026-04-27 Shanshan Ren , Thomas E. Bartlett , Lina Gerontogianni , Swati Chandna

Model-based clustering is widely used for identifying and distinguishing types of diseases. However, modern biomedical data coming with high dimensions make it challenging to perform the model estimation in traditional cluster analysis. The…

Methodology · Statistics 2025-07-22 Kazeem Kareem , Fan Dai

In the analysis of cluster data, the regression coefficients are frequently assumed to be the same across all clusters. This hampers the ability to study the varying impacts of factors on each cluster. In this paper, a semiparametric model…

Statistics Theory · Mathematics 2009-08-25 Wenyang Zhang , Jianqing Fan , Yan Sun

This paper considers the modeling of zero-inflated circular measurements concerning real case studies from medical sciences. Circular-circular regression models have been discussed in the statistical literature and illustrated with various…

Methodology · Statistics 2022-01-04 Jayant Jha , Prajamitra Bhuyan