Related papers: The Human Cell Atlas White Paper
A Genetic Algorithm (GA) is proposed in which each member of the population can change schemata only with its neighbors according to a rule. The rule methodology and the neighborhood structure employ elements from the Cellular Automata (CA)…
The human thalamus is a brain structure that comprises numerous, highly specific nuclei. Since these nuclei are known to have different functions and to be connected to different areas of the cerebral cortex, it is of great interest for the…
Across a far-reaching diversity of scientific and industrial applications, a general key problem involves relating the structure of time-series data to a meaningful outcome, such as detecting anomalous events from sensor recordings, or…
Hepatocellular carcinoma is the most spread primary liver cancer across the world ($\sim$80\% of the liver tumors). The gold standard for HCC diagnosis is liver biopsy. However, in the clinical routine, expert radiologists provide a visual…
Artificial intelligence has provided us with an exploration of a whole new research era. As more data and better computational power become available, the approach is being implemented in various fields. The demand for it in health…
This review introduces the transformative potential of generative Artificial Intelligence (AI) and foundation models, including large language models (LLMs), for health technology assessment (HTA). We explore their applications in four…
This report introduces the concept of "Highly Autonomous Cyber-Capable Agents" (HACCAs), AI systems capable of autonomously conducting multi-stage cyber campaigns at a level comparable to today's top criminal hacking groups or…
Inspired by cellular growth and self-organization, Neural Cellular Automata (NCAs) have been capable of "growing" artificial cells into images, 3D structures, and even functional machines. NCAs are flexible and robust computational systems…
A model of multicellular systems with several types of cells is developed from the phase field model. The model is presented as a set of partial differential equations of the field variables, each of which expresses the shape of one cell.…
The human capital invested into software development plays a vital role in the success of any software project. By human capital, we do not mean the individuals themselves, but involves the range of knowledge and skills (i.e., human…
Smart and IoT-enabled mobile devices have the potential to enhance healthcare services for both patients and healthcare providers. Human computer interaction design is key to realizing a useful and usable connection between the users and…
The fields of computing and biology have begun to cross paths in new ways. In this paper a review of the current research in biological computing is presented. Fundamental concepts are introduced and these foundational elements are explored…
The delivery of key services in domains ranging from finance and manufacturing to healthcare and transportation is underpinned by a rapidly growing number of mission-critical enterprise applications. Ensuring the continuity of these complex…
Cellular automata (CAs) are dynamical systems which exhibit complex global behavior from simple local interaction and computation. Since the inception of cellular automaton (CA) by von Neumann in 1950s, it has attracted the attention of…
Advances in bioinformatics are primarily due to new algorithms for processing diverse biological data sources. While sophisticated alignment algorithms have been pivotal in analyzing biological sequences, deep learning has substantially…
Biological organisms are composed of numerous interconnected biochemical processes. Diseases occur when normal functionality of these processes is disrupted. Thus, understanding these biochemical processes and their interrelationships is a…
This review was written for the Encyclopedia of Complexity and System Science (Springer-Verlag, Berlin, 2008), and is intended as a guide to the growing literature which approaches the phenomena of cell biology from a more theoretical point…
Life Cycle Assessment (LCA) is increasingly used to quantify and regulate the environmental impacts of Information and Communication Technology (ICT) systems. Since direct biosphere measurements are complicated to perform, we claim that the…
Systems Biology has emerged in the last years as a new holistic approach based on the global understanding of cells instead of only being focused on their individual parts (genes or proteins), to better understand the complexity of human…
Artificial immune systems, more specifically the negative selection algorithm, have previously been applied to intrusion detection. The aim of this research is to develop an intrusion detection system based on a novel concept in immunology,…