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We study a mathematical model describing the dynamics of a pluripotent stem cell population involved in the blood production process in the bone marrow. This model is a differential equation with a time delay. The delay describes the cell…

Analysis of PDEs · Mathematics 2009-04-17 Mostafa Adimy , Fabien Crauste , Shigui Ruan

We analyze the asymptotic stability of a nonlinear system of two differential equations with delay describing the dynamics of blood cell production. This process takes place in the bone marrow where stem cells differentiate throughout…

Analysis of PDEs · Mathematics 2009-04-17 Fabien Crauste

This paper is devoted to the study of the stability of limit cycles of a nonlinear delay differential equation with a distributed delay. The equation arises from a model of population dynamics describing the evolution of a pluripotent stem…

Analysis of PDEs · Mathematics 2009-04-17 Mostafa Adimy , Fabien Crauste , Andrei Halanay , Mihaela Neamtu , Dumitru Opris

Mackey-Glass equation arises in the leukemia model. We generalize this equation to include fractional-order derivatives in two directions. The first generalization contains one whereas the second contains two fractional derivatives. Such…

Dynamical Systems · Mathematics 2024-11-06 Deepa Gupta , Sachin Bhalekar

Hematopoiesis is a complex biological process that leads to the production and regulation of blood cells. It is based upon differentiation of stem cells under the action of growth factors. A mathematical approach of this process is proposed…

Classical Analysis and ODEs · Mathematics 2009-04-17 Mostafa Adimy , Fabien Crauste , Shigui Ruan

Proposed to study the dynamics of physiological systems in which the evolution depends on the state in a previous time, the Mackey-Glass model exhibits a rich variety of behaviors including periodic or chaotic solutions in vast regions of…

Disordered Systems and Neural Networks · Physics 2021-12-22 Juan P. Tarigo , Cecilia Stari , Cecilia Cabeza , Arturo C. Marti

Logistic functions are good models of biological population growth. They are also popular in marketing in modelling demand-supply curves and in a different context, to chart the sales of new products over time. Delays being inherent in any…

Populations and Evolution · Quantitative Biology 2012-11-30 Milind M. Rao , K. L. Preetish

We consider a delay differential equation that occurs in the study of chronic myelogenous leukemia. After shortly reminding some previous results concerning the stability of equilibrium solutions, we concentrate on the study of stability of…

Dynamical Systems · Mathematics 2010-03-23 Anca-Veronica Ion , Raluca-Mihaela Georgescu

We study the two state model which describes the balance equation for carbon dioxide and oxygen. These are nonlinear parameter dependent and because of the transport delay in the respiratory control system, they are modeled with delay…

Dynamical Systems · Mathematics 2022-06-29 Nirjal Sapkota , Janos Turi

Homeostasis, broadly speaking, refers to the maintenance of a stable internal state when faced with external stimuli. Failure to manage these regulatory processes can lead to different diseases or death. Most physiologists and cell…

Dynamical Systems · Mathematics 2025-05-20 Christopher J. Ryzowicz , Richard Bertram , Bhargav R. Karamched

This article proposes a non-autonomous mathematical model with delay for confrontation between two countries, and examines the stability of its equilibrium state. Our criteria for stability take into account the influence of the factor of…

Dynamical Systems · Mathematics 2026-05-14 Teresa Faria , Anatoliy A. Martynyuk

A cross-diffusion system modeling the information herding of individuals is analyzed in a bounded domain with no-flux boundary conditions. The variables are the species' density and an influence function which modifies the information state…

Analysis of PDEs · Mathematics 2018-12-24 Ansgar Jüngel , Christian Kuehn , Lara Trussardi

We develop a comprehensive mathematical model of platelet, megakaryocyte, and thrombopoietin dynamics in humans. We show that there is a single stationary solution that can undergo a Hopf bifurcation, and use this information to investigate…

The mathematical modelling of biological systems has historically followed one of two approaches: comprehensive and minimal. In comprehensive models, the involved biological pathways are modelled independently, then brought together as an…

Dynamical Systems · Mathematics 2021-11-16 Eric Ng , Jaycee Morgan Kaufman , Lennaert van Veen , Yan Fossat

Present work is a theoretical study on the stability of the thermotropic biaxial nematic liquid crystal phase in model systems. Its main aim is to present the phase diagrams of spatially uniform liquid mesophases and to identify the…

Soft Condensed Matter · Physics 2009-07-07 Piotr Grzybowski

A one - parameter dynamical system is associated to the mathematical problem governing the membrane excitability of a ventricular cardiomyocyte, according to the Luo-Rudy I model. An algorithm used to construct the equilibrium curve is…

The phase-field-crystal model for liquid crystals is solved numerically in two spatial dimensions. This model is formulated with three position-dependent order parameters, namely the reduced translational density, the local nematic order…

Soft Condensed Matter · Physics 2014-01-28 Cristian Vasile Achim , Raphael Wittkowski , Hartmut Löwen

The interrelation of dynamic processes active on separated time-scales in glasses and viscous liquids is investigated using a model displaying two time-scale bifurcations both between fast and secondary relaxation and between secondary and…

Disordered Systems and Neural Networks · Physics 2015-03-19 Andrea Crisanti , Luca Leuzzi , Matteo Paoluzzi

A four-dimensional mathematical model of the hypothalamus-pituitary-adrenal (HPA) axis is investigated, incorporating the influence of the GR concentration and general feedback functions. The inclusion of distributed time delays provides a…

Dynamical Systems · Mathematics 2018-12-26 Eva Kaslik , Mihaela Neamtu

Biochemical reactions with oscillatory behavior play an essential role in synthetic biology at the microscopic scale. Although a robust stability theory for deterministic chemical oscillators in the macroscopic limit exists, the dynamical…

Molecular Networks · Quantitative Biology 2019-02-27 Pedro H. Constantino , Yiannis N. Kaznessis
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