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We proposed a method to achieve superresolved optical imaging without beating the diffraction limit of light. This is achieved by magnifying the ideal optical image of the object through higher-order spatial frequency generation while…

Optics · Physics 2016-08-08 Zhixiang Li , Jianji Liu , Guoquan Zhang

Modulation-enhanced localization microscopy (MELM) has demonstrated significant improvements in both lateral and axial localization precision compared to conventional single-molecule localization microscopy (SMLM). However, lateral…

Although several optical techniques have been recently developed in order to overcome the resolution limit in microscopy, the imaging of sub-wavelength features is still a real challenge. In practise, super-resolution techniques remain…

Physics Education · Physics 2019-07-24 Stephane Perrin , Keshia Badu , Paul Montgomery , Sylvain Lecler

In fluorescence microscopy live-cell imaging, there is a critical trade-off between the signal-to-noise ratio and spatial resolution on one side, and the integrity of the biological sample on the other side. To obtain clean high-resolution…

Image and Video Processing · Electrical Eng. & Systems 2020-08-25 Ruofan Zhou , Majed El Helou , Daniel Sage , Thierry Laroche , Arne Seitz , Sabine Süsstrunk

The revolutionary technology of \emph{Stacked Intelligent Metasurfaces (SIM)} has been recently shown to be capable of carrying out advanced signal processing directly in the native electromagnetic (EM) wave domain. An SIM is fabricated by…

Information Theory · Computer Science 2023-05-16 Jiancheng An , Chao Xu , Derrick Wing Kwan Ng , George C. Alexandropoulos , Chongwen Huang , Chau Yuen , Lajos Hanzo

Recent progress has boosted the resolving power of optical microscopies to spatial dimensions well below the diffraction limit. Yet, axial super-resolution and axial single-molecule localisation typically require more complicated…

Integral Field Spectroscopy (IFS) is an observational method to obtain spatially resolved spectra over a specific field of view (FoV) in a single exposure. In recent years, near-infrared IFS has gained importance in observing objects with…

This article presents a method to perform diffraction tomography in a standard microscope that includes an LED array for illumination. After acquiring a sequence of intensity-only images of a thick sample, a ptychography-based…

Optics · Physics 2015-10-30 Roarke Horstmeyer , Changhuei Yang

We developed a Bessel light sheet fluorescence microscopy (LSFM) system to enable high-speed, wide-field intra-vital imaging of zebrafish and other thick biological samples. This system uses air objectives for the convenient mounting of…

Optics · Physics 2023-11-07 Chuhui Wang , Jiaju Chen , Cuiyi Peng , Zhenglin Chen , Dongmei Yu , Peiwu Qin

It is now generally accepted that Euclidean-based metrics may not always adequately represent the subjective judgement of a human observer. As a result, many image processing methodologies have been recently extended to take advantage of…

Optimization and Control · Mathematics 2020-02-10 D. Otero , D. La Torre , O. Michailovich , E. R. Vrscay

Single Pixel (SP) imaging is now a reality in many applications, e.g., biomedical ultrathin endoscope and fluorescent spectroscopy. In this context, many schemes exist to improve the light throughput of these device, e.g., using structured…

Computer Vision and Pattern Recognition · Computer Science 2019-02-19 Amirafshar Moshtaghpour , José M. Bioucas-Dias , Laurent Jacques

To address the limited wave domain signal processing capabilities of traditional single-polarized stacked intelligent metasurfaces (SIMs) in holographic multiple-input multiple-output (HMIMO) systems, which stems from limited integration…

Signal Processing · Electrical Eng. & Systems 2025-05-28 Yida Zhang , Qiuyan Liu , Hongtao Luo , Yuqi Xia , Qiang Wang

We developed analytical technique for extracting the phase, visibility and amplitude information as needed for interferometric astrometry with the Space Interferometry Mission (SIM). Our model accounts for a number of physical and…

Optics · Physics 2008-11-26 Slava G. Turyshev

Stacked intelligent metasurfaces (SIMs) have recently gained attention as a paradigm for wave-domain signal processing with reduced reliance on costly radio-frequency (RF) chains. However, conventional SIMs rely on uniform inter-layer…

Information Theory · Computer Science 2025-10-29 Hong Niu , Jiancheng An , Chau Yuen

Intraoperative optical imaging is essential for surgical precision and patient safety, but current systems present anatomical and fluorescence information separately, causing delays and increasing cognitive load. A unified system for…

Medical Physics · Physics 2025-09-22 Kyriakos Pentarakis , George Kakavelakis , Constantinos Petridis , George Themelis

A universal methodology for coding-decoding the complex amplitude field of an imaged sample in coherent microscopy is presented, where no restrictions on any of the two interferometric beams are required. Thus, the imaging beam can be…

Acquiring high-contrast optical images deep inside biological tissues is still a challenging problem. Confocal microscopy is an important tool for biomedical imaging since it improves image quality by rejecting background signals. However,…

Scanning Electron Microscopy (SEM) is pivotal in revealing intricate micro- and nanoscale features across various research fields. However, obtaining high-resolution SEM images presents challenges, including prolonged scanning durations and…

Image and Video Processing · Electrical Eng. & Systems 2024-10-08 Tom Reclik , Setareh Medghalchi , Philipp Schumacher , Maximilian Wollenweber , Talal Al-Samman , Sandra Korte-Kerzel , Ulrich Kerzel

The deployment of Extremely Large-Scale Antenna Arrays for 6G enables radiative near-field sensing but poses significant challenges in terms of hardware complexity and interference. Stacked Intelligent Metasurfaces (SIMs) address these…

Signal Processing · Electrical Eng. & Systems 2026-05-25 Andrea Abrardo , Bartoli Giulio

Wide-field imaging is widely adopted due to its fast acquisition, cost-effectiveness and ease of use. Its extension to direct volumetric applications, however, is burdened by the trade-off between resolution and depth of field (DOF),…