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We present an efficient algorithm for calculating the minimum energy path (MEP) and energy barriers between local minima on a multidimensional potential energy surface (PES). Such paths play a central role in the understanding of transition…

Computational Physics · Physics 2012-04-19 Amit Samanta , Weinan E

Minimum energy paths for transitions such as atomic and/or spin rearrangements in thermalized systems are the transition paths of largest statistical weight. Such paths are frequently calculated using the nudged elastic band method, where…

We study numerically the minimum energy path and energy barriers for dislocation nucleation in a two-dimensional atomistic model of strained epitaxial layers on a substrate with lattice misfit. Stress relaxation processes from coherent to…

Materials Science · Physics 2009-11-07 O. Trushin , E. Granato , S. C. Ying , P. Salo , T. Ala-Nissila

An analysis of the network defined by the potential energy minima of multi-atomic systems and their connectivity via reaction pathways that go through transition states allows to understand important characteristics like thermodynamic,…

Materials Science · Physics 2016-08-03 Bastian Schaefer , Stefan Goedecker

A method is presented for generating a good initial guess of a transition path between given initial and final states of a system without evaluation of the energy. An objective function surface is constructed using an interpolation of…

Materials Science · Physics 2014-06-19 Søren Smidstrup , Andreas Pedersen , Kurt Stokbro , Hannes Jónsson

Efficient algorithms for the calculation of minimum energy paths of magnetic transitions are implemented within the geodesic nudged elastic band (GNEB) approach. While an objective function is not available for GNEB and a traditional line…

Computational Physics · Physics 2020-11-30 Aleksei V. Ivanov , Damjan Dagbartsson , Julien Tranchida , Valery M. Uzdin , Hannes Jónsson

Characterizing conformational transitions in physical systems remains a fundamental challenge, as traditional sampling methods struggle with the high-dimensional nature of molecular systems and high-energy barriers between stable states.…

Chemical Physics · Physics 2025-09-22 Magnus Petersen , Gemma Roig , Roberto Covino

The minimum energy path (MEP) is the most probable transition path that connects two equilibrium states of a potential energy landscape. It has been widely used to study transition mechanisms as well as transition rates in the fields of…

Numerical Analysis · Mathematics 2022-07-01 Xuanyu Liu , Huajie Chen , Christoph Ortner

The nudged elastic band (NEB) method is a commonly used approach for the calculation of minimum energy pathways of kinetic processes. However, the final paths obtained rely heavily on the nature of the initially chosen path. This often…

Materials Science · Physics 2019-04-30 Jason M. Munro , Vincent S. Liu , Venkatraman Gopalan , Ismaila Dabo

We present a modified version of the nudged elastic band (NEB) algorithm to find minimum energy paths con-necting two known configurations. We show that replacing the harmonic band-energy term with a discretized version of the…

Computational Physics · Physics 2024-06-19 Davide Mandelli , Michele Parrinello

The minimum action method (MAM) is to calculate the most probable transition path in randomly perturbed stochastic dynamics, based on the idea of action minimization in the path space. The accuracy of the numerical path between different…

Computational Physics · Physics 2017-05-26 Y Sun , X Zhou

The nudged elastic band (NEB) method is the standard approach for finding minimum energy paths and transition states on potential energy surfaces. Practical NEB calculations require several pre-processing steps: endpoint minimization,…

Chemical Physics · Physics 2026-04-17 Rohit Goswami

Transition states and minimum energy paths are essential to understand and predict chemical reactivity. Double-ended methods represent a standard approach for their determination. We introduce a new double-ended method that optimizes…

Chemical Physics · Physics 2020-02-18 Alain C. Vaucher , Markus Reiher

A method combining denoising diffusion probabilistic models (DDPMs) with the string method is presented to generate minimum free energy paths between metastable states in molecular systems. It has been demonstrated in recent work that DDPMs…

Chemical Physics · Physics 2024-12-17 Vladimir Grigorev

Rare transition events in meta-stable systems under noisy fluctuations are crucial for many non-equilibrium physical and chemical processes. In these processes, the primary contributions to reactive flux are predominantly near the…

Chemical Physics · Physics 2024-08-26 Jiayue Han , Shuting Gu , Xiang Zhou

We study numerically the energetics and atomic mechanisms of misfit dislocation nucleation and stress relaxation in a two-dimensional atomistic model of strained epitaxial layers on a substrate with lattice misfit. Relaxation processes from…

Materials Science · Physics 2009-11-10 O. Trushin , E. Granato , S. C. Ying , P. Salo , T. Ala-Nissila

The Minima Hopping global optimization method uses physically realizable molecular dynamics moves in combination with an energy feedback that guarantees the escape from any potential energy funnel. For the purpose of finding reactions…

Materials Science · Physics 2014-06-05 Bastian Schaefer , Stephan Mohr , Maximilian Amsler , Stefan Goedecker

Molecule synthesis through machine learning is one of the fundamental problems in drug discovery. Current data-driven strategies employ one-step retrosynthesis models and search algorithms to predict synthetic routes in a top-bottom manner.…

Machine Learning · Computer Science 2024-06-05 Songtao Liu , Hanjun Dai , Yue Zhao , Peng Liu

The computational efficiency of stochastic simulation algorithms is notoriously limited by the kinetic trapping of the simulated trajectories within low energy basins. Here we present a new method that overcomes kinetic trapping while still…

Statistical Mechanics · Physics 2014-12-08 Manuel Athènes , Vasily V. Bulatov

Power system restoration after a major blackout is a complex process, in which selection of energising paths is a key issue to realize unit and load restoration safely and efficiently. In general, the energising path scheme made beforehand…

Signal Processing · Electrical Eng. & Systems 2019-03-13 Shaoyan Li , Xueping Gu , Guangqi Zhou , Yang Li
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