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The recent boom in computational chemistry has enabled several projects aimed at discovering useful materials or catalysts. We acknowledge and address two recurring issues in the field of computational catalyst discovery. First, calculating…

Chemical Physics · Physics 2021-04-07 Kevin Tran , Willie Neiswanger , Kirby Broderick , Erix Xing , Jeff Schneider , Zachary W. Ulissi

This report details our submission to the Mitotic Domain Generalization (MIDOG) 2025 challenge, which addresses the critical task of mitotic figure detection in histopathology for cancer prognostication. Following the "Bitter…

Image and Video Processing · Electrical Eng. & Systems 2025-09-04 Zhuoyan Shen , Esther Bär , Maria Hawkins , Konstantin Bräutigam , Charles-Antoine Collins-Fekete

Melanoma is considered to be the most aggressive form of skin cancer. Due to the similar shape of malignant and benign cancerous lesions, doctors spend considerably more time when diagnosing these findings. At present, the evaluation of…

Image and Video Processing · Electrical Eng. & Systems 2022-05-24 Daniel Kvak

Histopathological analysis is the present gold standard for precancerous lesion diagnosis. The goal of automated histopathological classification from digital images requires supervised training, which requires a large number of expert…

Image and Video Processing · Electrical Eng. & Systems 2021-11-15 Yuan Xue , Jiarong Ye , Qianying Zhou , Rodney Long , Sameer Antani , Zhiyun Xue , Carl Cornwell , Richard Zaino , Keith Cheng , Xiaolei Huang

The spectacular response observed in clinical trials of immunotherapy in patients with previously uncurable Melanoma, a highly aggressive form of skin cancer, calls for a better understanding of the cancer-immune interface. Computational…

Computer Vision and Pattern Recognition · Computer Science 2018-08-08 Konstantinos Zormpas-Petridis , Henrik Failmezger , Ioannis Roxanis , Matthew Blackledge , Yann Jamin , Yinyin Yuan

Brain metastases affect approximately between 20% and 40% of cancer patients and are commonly treated with radiotherapy or radiosurgery. Early prediction of recurrence following treatment could enable timely clinical intervention and…

Image and Video Processing · Electrical Eng. & Systems 2025-12-18 Ines Faria , Matheus Silva , Crystian Saraiva , Jose Soares , Victor Alves

Hyperpolarized 13C-MRI allows real time observation of metabolism in vivo. Imaging sequences have been developed to follow the metabolism of [1-13C] pyruvate and extract reaction kinetics, which can show tumour treatment response. We…

Biomolecules · Quantitative Biology 2018-01-08 Junzhe Zhao

Mitotic count (MC) is an important histological parameter for cancer diagnosis and grading, but the manual process for obtaining MC from whole-slide histopathological images is very time-consuming and prone to error. Therefore, deep…

Computer Vision and Pattern Recognition · Computer Science 2022-03-01 Chawan Piansaddhayanon , Sakun Santisukwongchote , Shanop Shuangshoti , Qingyi Tao , Sira Sriswasdi , Ekapol Chuangsuwanich

Image-based sequencing of mRNA makes it possible to see where in a tissue sample a given gene is active, and thus discern large numbers of different cell types in parallel. This is crucial for gaining a better understanding of tissue…

Quantitative Methods · Quantitative Biology 2018-02-27 Gabriele Partel , Giorgia Milli , Carolina Wählby

Tumor proliferation is an important biomarker indicative of the prognosis of breast cancer patients. Assessment of tumor proliferation in a clinical setting is highly subjective and labor-intensive task. Previous efforts to automate tumor…

Detecting and segmenting individual cells from microscopy images is critical to various life science applications. Traditional cell segmentation tools are often ill-suited for applications in brightfield microscopy due to poor contrast and…

Image and Video Processing · Electrical Eng. & Systems 2020-05-20 Rituparna Sarkar , Suvadip Mukherjee , Elisabeth Labruyère , Jean-Christophe Olivo-Marin

Microscopy imaging plays a vital role in understanding many biological processes in development and disease. The recent advances in automation of microscopes and development of methods and markers for live cell imaging has led to rapid…

Computer Vision and Pattern Recognition · Computer Science 2017-05-10 Saad Ullah Akram , Juho Kannala , Lauri Eklund , Janne Heikkilä

Motivation: Accurate classification of mitotic figures into normal and atypical types is crucial for tumor prognostication in digital pathology. However, developing robust deep learning models for this task is challenging due to the subtle…

Image and Video Processing · Electrical Eng. & Systems 2025-09-16 Sujatha Kotte , Vangala Govindakrishnan Saipradeep , Vidushi Walia , Dhandapani Nandagopal , Thomas Joseph , Naveen Sivadasan , Bhagat Singh Lali

Weakly-supervised classification of histopathology slides is a computationally intensive task, with a typical whole slide image (WSI) containing billions of pixels to process. We propose Discriminative Region Active Sampling for Multiple…

Image and Video Processing · Electrical Eng. & Systems 2023-02-23 Jack Breen , Katie Allen , Kieran Zucker , Geoff Hall , Nicolas M. Orsi , Nishant Ravikumar

We consider preoperative prediction of thyroid cancer based on ultra-high-resolution whole-slide cytopathology images. Inspired by how human experts perform diagnosis, our approach first identifies and classifies diagnostic image regions…

Computer Vision and Pattern Recognition · Computer Science 2020-02-11 David Dov , Shahar Kovalsky , Jonathan Cohen , Danielle Range , Ricardo Henao , Lawrence Carin

Mitotic counts are one of the key indicators of breast cancer prognosis. However, accurate mitotic cell counting is still a difficult problem and is labourious. Automated methods have been proposed for this task, but are usually dependent…

Computer Vision and Pattern Recognition · Computer Science 2021-09-28 Salar Razavi , Fariba Dambandkhameneh , Dimitri Androutsos , Susan Done , April Khademi

Histology method is vital in the diagnosis and prognosis of cancers and many other diseases. For the analysis of histopathological images, we need to detect and segment all gland structures. These images are very challenging, and the task…

Image and Video Processing · Electrical Eng. & Systems 2019-11-05 Safiye Rezaei , Ali Emami , Nader Karimi , Shadrokh Samavi

With the advance of imaging technology, digital pathology imaging of tumor tissue slides is becoming a routine clinical procedure for cancer diagnosis. This process produces massive imaging data that capture histological details in high…

Methodology · Statistics 2020-12-10 Qiwei Li , Xinlei Wang , Faming Liang , Guanghua Xiao

This paper presents our solution for the MIDOG 2025 Challenge Track 2, which focuses on binary classification of normal mitotic figures (NMFs) versus atypical mitotic figures (AMFs) in histopathological images. Our approach leverages a…

Computer Vision and Pattern Recognition · Computer Science 2025-08-27 Yosuke Yamagishi , Shouhei Hanaoka

Breast cancer is the most diagnosed cancer and the most predominant cause of death in women worldwide. Imaging techniques such as the breast cancer pathology helps in the diagnosis and monitoring of the disease. However identification of…

Image and Video Processing · Electrical Eng. & Systems 2019-08-06 Francisco Perdigon Romero , An Tang , Samuel Kadoury
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