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Joint models for longitudinal and time-to-event data are commonly used in longitudinal studies to forecast disease trajectories over time. While there are many advantages to joint modeling, the standard forms suffer from limitations that…

Machine Learning · Statistics 2019-09-09 Bryan Lim , Mihaela van der Schaar

This work proposes the use of 3D convolutional variational autoencoders (CVAEs) to trace the changes and symptomatology produced by neurodegeneration in Parkinson's disease (PD). In this work, we present a novel approach to detect and…

Image and Video Processing · Electrical Eng. & Systems 2023-05-15 E. Delgado de las Heras , F. J. Martinez-Murcia , I. A. Illán , C. Jiménez-Mesa , D. Castillo-Barnes , J. Ramírez , J. M. Górriz

This study presents Latent Diffusion Autoencoder (LDAE), a novel encoder-decoder diffusion-based framework for efficient and meaningful unsupervised learning in medical imaging, focusing on Alzheimer disease (AD) using brain MR from the…

Computer Vision and Pattern Recognition · Computer Science 2026-01-12 Gabriele Lozupone , Alessandro Bria , Francesco Fontanella , Frederick J. A. Meijer , Claudio De Stefano , Henkjan Huisman

In a longitudinal clinical registry, different measurement instruments might have been used for assessing individuals at different time points. To combine them, we investigate deep learning techniques for obtaining a joint latent…

Machine Learning · Computer Science 2023-12-04 Maren Hackenberg , Michelle Pfaffenlehner , Max Behrens , Astrid Pechmann , Janbernd Kirschner , Harald Binder

Inspired by the success of deep learning techniques in the physical and chemical sciences, we apply a modification of an autoencoder type deep neural network to the task of dimension reduction of molecular dynamics data. We can show that…

Machine Learning · Statistics 2018-04-04 Christoph Wehmeyer , Frank Noé

During the diagnostic process, clinicians leverage multimodal information, such as chief complaints, medical images, and laboratory-test results. Deep-learning models for aiding diagnosis have yet to meet this requirement. Here we report a…

Computer Vision and Pattern Recognition · Computer Science 2023-06-02 Hong-Yu Zhou , Yizhou Yu , Chengdi Wang , Shu Zhang , Yuanxu Gao , Jia Pan , Jun Shao , Guangming Lu , Kang Zhang , Weimin Li

Cardiovascular disease and chronic kidney disease are major complications of diabetes, leading to high morbidity and mortality. Early detection of these conditions is critical, yet traditional diagnostic markers often lack sensitivity in…

Other Quantitative Biology · Quantitative Biology 2025-10-20 Syed Ibad Hasnain

Deep convolutional neural networks (CNNs) have brought breakthroughs in processing clinical electrocardiograms (ECGs), speaker-independent speech and complex images. However, typical CNNs require a fixed input size while it is common to…

Machine Learning · Computer Science 2022-10-07 Linpeng Jin

Dementia is under-recognized in the community, under-diagnosed by healthcare professionals, and under-coded in claims data. Information on cognitive dysfunction, however, is often found in unstructured clinician notes within medical records…

Conventionally, autoencoders are unsupervised representation learning tools. In this work, we propose a novel discriminative autoencoder. Use of supervised discriminative learning ensures that the learned representation is robust to…

Computer Vision and Pattern Recognition · Computer Science 2019-12-30 Anupriya Gogna , Angshul Majumdar

Steering a car through traffic is a complex task that is difficult to cast into algorithms. Therefore, researchers turn to training artificial neural networks from front-facing camera data stream along with the associated steering angles.…

Machine Learning · Computer Science 2017-11-23 Hesham M. Eraqi , Mohamed N. Moustafa , Jens Honer

Advancements in machine learning algorithms have had a beneficial impact on representation learning, classification, and prediction models built using electronic health record (EHR) data. Effort has been put both on increasing models'…

Machine Learning · Computer Science 2021-03-24 Yiwen Meng , William Speier , Michael K. Ong , Corey W. Arnold

Joint models for longitudinal and time-to-event data are commonly used in longitudinal studies to forecast disease trajectories over time. Despite the many advantages of joint modeling, the standard forms suffer from limitations that arise…

Machine Learning · Statistics 2018-07-10 Bryan Lim , Mihaela van der Schaar

Modern medicine requires generalised approaches to the synthesis and integration of multimodal data, often at different biological scales, that can be applied to a variety of evidence structures, such as complex disease analyses and…

Quantitative Methods · Quantitative Biology 2019-11-11 Devin Taylor , Simeon Spasov , Pietro Liò

The autoencoder is an artificial neural network model that learns hidden representations of unlabeled data. With a linear transfer function it is similar to the principal component analysis (PCA). While both methods use weight vectors for…

Computer Vision and Pattern Recognition · Computer Science 2019-02-04 Ya Ju Fan

Generative data augmentation with latent diffusion models is a promising strategy for addressing class imbalance in medical imaging, yet current approaches focus on perceptual fidelity and domain-specific autoencoder fine-tuning while…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Mischa Dombrowski , Felix Nützel , Bernhard Kainz

Interpretability is essential in medical imaging to ensure that clinicians can comprehend and trust artificial intelligence models. In this paper, we propose a novel interpretable approach that combines attribute regularization of the…

Image and Video Processing · Electrical Eng. & Systems 2023-12-15 Maxime Di Folco , Cosmin I. Bercea , Julia A. Schnabel

The early detection of potential failures in industrial machinery components is paramount for ensuring the reliability and safety of operations, thereby preserving Machine Condition Monitoring (MCM). This research addresses this imperative…

Sound · Computer Science 2024-10-28 Sahan Dissanayaka , Manjusri Wickramasinghe , Pasindu Marasinghe

The rich chemical information from tissue metabolomics provides a powerful means to elaborate tissue physiology or tumor characteristics at cellular and tumor microenvironment levels. However, the process of obtaining such information…