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Spectral kernel methods are techniques for transforming data into a coordinate system that efficiently reveals the geometric structure - in particular, the "connectivity" - of the data. These methods depend on certain tuning parameters. We…

Methodology · Statistics 2008-11-04 Ann B. Lee , Larry Wasserman

There are two key issues for the kernel-based regularization method: one is how to design a suitable kernel to embed in the kernel the prior knowledge of the LTI system to be identified, and the other one is how to tune the kernel such that…

Systems and Control · Computer Science 2017-08-01 Tianshi Chen

We propose a diffusion approximation method to the continuous-state Markov Decision Processes (MDPs) that can be utilized to address autonomous navigation and control in unstructured off-road environments. In contrast to most…

Robotics · Computer Science 2024-02-08 Junhong Xu , Kai Yin , Zheng Chen , Jason M. Gregory , Ethan A. Stump , Lantao Liu

In this paper, we study the problem of identifying the impulse response of a linear time invariant (LTI) dynamical system from the knowledge of the input signal and a finite set of noisy output observations. We adopt an approach based on…

Systems and Control · Computer Science 2015-03-20 Francesco Dinuzzo

Data-driven control algorithms use observations of system dynamics to construct an implicit model for the purpose of control. However, in practice, data-driven techniques often require excessive sample sizes, which may be infeasible in…

Systems and Control · Electrical Eng. & Systems 2023-01-10 Adam J. Thorpe , Cyrus Neary , Franck Djeumou , Meeko M. K. Oishi , Ufuk Topcu

Molecular dynamics simulations allow to study the structure and dynamics of single biomolecules in microscopic detail. However, many processes occur on time scales beyond the reach of fully atomistic simulations and require coarse-grained…

Statistical Mechanics · Physics 2019-09-04 Fabian Knoch , Thomas Speck

A simple and interpretable way to learn a dynamical system from data is to interpolate its vector-field with a kernel. In particular, this strategy is highly efficient (both in terms of accuracy and complexity) when the kernel is…

Machine Learning · Statistics 2024-10-07 Jonghyeon Lee , Edward De Brouwer , Boumediene Hamzi , Houman Owhadi

Multiple kernel methods based on k-means aims to integrate a group of kernels to improve the performance of kernel k-means clustering. However, we observe that most existing multiple kernel k-means methods exploit the nonlinear relationship…

Machine Learning · Computer Science 2020-10-01 Liang Du , Haiying Zhang , Xin Ren , Xiaolin Lv

MOTIVATION: Proteins fold into complex structures that are crucial for their biological functions. Experimental determination of protein structures is costly and therefore limited to a small fraction of all known proteins. Hence, different…

Biomolecules · Quantitative Biology 2018-04-18 David Menéndez Hurtado , Karolis Uziela , Arne Elofsson

Building highly non-linear and non-parametric models is central to several state-of-the-art machine learning systems. Kernel methods form an important class of techniques that induce a reproducing kernel Hilbert space (RKHS) for inferring…

Machine Learning · Statistics 2017-11-16 Huan Song , Jayaraman J. Thiagarajan , Prasanna Sattigeri , Andreas Spanias

This paper addresses a kernel-based learning problem for a network of agents locally observing a latent multidimensional, nonlinear phenomenon in a noisy environment. We propose a learning algorithm that requires only mild a priori…

Multiagent Systems · Computer Science 2024-04-16 Krzysztof Kowalczyk , Paweł Wachel , Cristian R. Rojas

With the advent of kernel methods, automating the task of specifying a suitable kernel has become increasingly important. In this context, the Multiple Kernel Learning (MKL) problem of finding a combination of pre-specified base kernels…

Machine Learning · Computer Science 2012-07-03 Abhishek Kumar , Alexandru Niculescu-Mizil , Koray Kavukcuoglu , Hal Daume

Kernel regression is a popular non-parametric fitting technique. It aims at learning a function which estimates the targets for test inputs as precise as possible. Generally, the function value for a test input is estimated by a weighted…

Machine Learning · Computer Science 2017-12-27 Rongqing Huang , Shiliang Sun

Simulations of biological macromolecules play an important role in understanding the physical basis of a number of complex processes such as protein folding. Even with increasing computational power and evolution of specialized…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-09-18 Hyungro Lee , Heng Ma , Matteo Turilli , Debsindhu Bhowmik , Shantenu Jha , Arvind Ramanathan

Most statistical classifiers are designed to find patterns in data where numbers fit into rows and columns, like in a spreadsheet, but many kinds of data do not conform to this structure. To uncover patterns in non-conforming data, we…

Quantitative Methods · Quantitative Biology 2021-03-22 Jared Ostmeyer , Scott Christley , Lindsay Cowell

Motivation: In a predictive modeling setting, if sufficient details of the system behavior are known, one can build and use a simulation for making predictions. When sufficient system details are not known, one typically turns to machine…

Machine Learning · Statistics 2019-08-14 Timo M. Deist , Andrew Patti , Zhaoqi Wang , David Krane , Taylor Sorenson , David Craft

Temperature is a fundamental regulator of chemical and biochemical kinetics, yet capturing nonlinear thermal effects directly from experimental data remains a major challenge due to limited throughput and model flexibility. Recent advances…

Quantitative Methods · Quantitative Biology 2025-12-23 Mamoru Saita , Yutaka Hori

Learning a kernel matrix from relative comparison human feedback is an important problem with applications in collaborative filtering, object retrieval, and search. For learning a kernel over a large number of objects, existing methods face…

Machine Learning · Computer Science 2015-01-13 Eric Heim , Matthew Berger , Lee M. Seversky , Milos Hauskrecht

Much of our mechanistic understanding of the functions of biological macromolecules is based on static structural experiments, which can be modelled either as single structures or conformational ensembles. While these provide us with…

Biomolecules · Quantitative Biology 2025-10-02 Daria Gusew , Carl G. Henning Hansen , Kresten Lindorff-Larsen

Kernel survival analysis models estimate individual survival distributions with the help of a kernel function, which measures the similarity between any two data points. Such a kernel function can be learned using deep kernel survival…

Machine Learning · Computer Science 2025-02-18 George H. Chen