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Introduction. Treatment planning systems (TPS) are an essential component for simulating and optimizing a radiation therapy treatment before administering it to the patient. It ensures that the tumor is well covered and the dose to the…

Radiation therapy treatment planning is an iterative, expertise-dependent process, and the growing burden of cancer cases has made reliance on manual planning increasingly unsustainable, underscoring the need for automation. In this study,…

Medical Physics · Physics 2025-10-15 Dongrong Yang , Xin Wu , Yibo Xie , Xinyi Li , Qiuwen Wu , Jackie Wu , Yang Sheng

Objective: Radiation therapy treatment planning is a time-consuming process involving iterative adjustments of hyperparameters. To automate the treatment planning process, we propose a meta-optimization framework, called MetaPlanner (MP).…

Medical Physics · Physics 2022-02-22 Charles Huang , Yusuke Nomura , Yong Yang , Lei Xing

To develop an automated workflow for rectal cancer three-dimensional conformal radiotherapy treatment planning that combines deep-learning(DL) aperture predictions and forward-planning algorithms. We designed an algorithm to automate the…

Objective: Radiotherapy treatment planning is a time-consuming and potentially subjective process that requires the iterative adjustment of model parameters to balance multiple conflicting objectives. Recent advancements in frontier…

This study investigates the applicability of 3D dose predictions from a model trained on one modality to a cross-modality automated planning workflow. Additionally, we explore the impact of integrating a multi-criteria optimizer on adapting…

Medical Physics · Physics 2024-02-26 Gregory Szalkowski , Xuanang Xu , Shiva Das , Pew-Thian Yap , Jun Lian

We propose an oAPT workflow that incorporates all these functionalities and validate its clinical implementation feasibility with prostate patients. AI-based auto-segmentation tool AccuContourTM (Manteia, Xiamen, China) was seamlessly…

Artificial intelligence-based radiation therapy (RT) planning has the potential to reduce planning time and inter-planner variability, improving efficiency and consistency in clinical workflows. Most existing automated approaches rely on…

Robust fine tuning of multi-leaf collimator (MLC) Treatment Planning System (TPS) modeling parameters is crucial for creating an optimal beam model, particularly with the ever-increasing accuracy required for advancing techniques.…

Radiotherapy (RT) planning is complex, subjective, and time-intensive. Advances with artificial intelligence (AI) promise to improve its precision and efficiency, but progress is often limited by the scarcity of large, standardized…

Radiotherapy inverse planning often requires planners to modify parameters in the treatment planning system's objective function to produce clinically acceptable plans. Due to the manual steps in this process, plan quality can vary…

Medical Physics · Physics 2022-05-11 Kelsey Maass , Aleksandr Aravkin , Minsun Kim

High dose-rate brachytherapy (HDRBT) is widely used for gynecological cancer treatment. Although commercial treatment planning systems (TPSs) have inverse optimization modules, it takes several iterations to adjust planning objectives to…

Medical Physics · Physics 2021-09-14 Huan Liu , Chang M Ma , Xun Jia , Chenyang Shen , Peter Klages , Kevin Albuquerque

We have previously described RapidBrachyMCTPS, a brachytherapy treatment planning toolkit consisting of a graphical user interface (GUI) and a Geant4-based Monte Carlo (MC) dose calculation engine. This work describes the tools that have…

Medical Physics · Physics 2020-07-07 Harry Glickman , Majd Antaki , Christopher Deufel , Shirin A. Enger

Background: Intensity-modulated proton therapy (IMPT) using pencil beam technique scans tumor in a layer by layer, then spot by spot manner. It can provide highly conformal dose to tumor targets and spare nearby organs-at-risk (OAR). Fast…

Medical Physics · Physics 2024-11-28 Aoxiang Wang , Ya-Nan Zhu , Jufri Setianegara , Yuting Lin , Peng Xiao , Qingguo Xie , Hao Gao

Objective: Tumor Treating Fields (TTFields) is an emerging approach for cancer therapy that inhibits tumor cell proliferation by applying alternating electric fields (EF) of intermediate frequency and low intensity. The TTFields-induced…

Medical Physics · Physics 2024-10-17 Minmin Wang , Xu Xie , Zhengbo Fan , Yue Lan , Yun Pan , Guangdi Chen , Shaomin Zhang , Yuxing Wang

Noncoplanar radiation therapy treatment planning has the potential to improve dosimetric quality as compared to traditional coplanar techniques. Likewise, automated treatment planning algorithms can reduce a planner's active treatment…

Medical Physics · Physics 2022-01-19 Charles Huang , Yong Yang , Lei Xing

Radiation therapy (RT) is a medical treatment to kill cancer cells or shrink tumors. To manually schedule patients for RT is a time-consuming and challenging task. By the use of optimization, patient schedules for RT can be created…

Optimization and Control · Mathematics 2023-05-04 Sara Frimodig , Per Enqvist , Mats Carlsson , Carole Mercier

The goal of text simplification (TS) is to transform difficult text into a version that is easier to understand and more broadly accessible to a wide variety of readers. In some domains, such as healthcare, fully automated approaches cannot…

Computation and Language · Computer Science 2020-10-22 Hoang Van , David Kauchak , Gondy Leroy

Objective: Radiation therapy treatment planning is a time-consuming, iterative process with potentially high inter-planner variability. Fully automated treatment planning processes could reduce a planner's active treatment planning time and…

Medical Physics · Physics 2021-02-09 Charles Huang , Yong Yang , Neil Panjwani , Stephen Boyd , Lei Xing

The predicted increase in the number of patients receiving radiation therapy (RT) to treat cancer calls for an optimized use of resources. To manually schedule patients on the linear accelerators delivering RT is a time-consuming and…

Optimization and Control · Mathematics 2023-03-29 Sara Frimodig , Carole Mercier , Geert De Kerf
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