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The study of network structure has uncovered signatures of the organization of complex systems. However, there is also a need to understand how to control them; for example, identifying strategies to revert a diseased cell to a healthy…

Molecular Networks · Quantitative Biology 2016-04-19 Alexander J. Gates , Luis M. Rocha

Motivated by the reported peculiar dynamics of a red blood cell in shear flow, we develop an analytical theory for the motion of a nearly--spherical fluid particle enclosed by a visco--elastic incompressible interface in linear flows. The…

Fluid Dynamics · Physics 2010-07-06 Petia M. Vlahovska , Yuan-nan Young , Gerrit Danker , Chaouqi Misbah

We consider a model of large regulatory gene expression networks where the thresholds activating the sigmoidal interactions between genes and the signs of these interactions are shuffled randomly. Such an approach allows for a qualitative…

Molecular Networks · Quantitative Biology 2007-05-23 D. Volchenkov , R. Lima

Homophily and social influence are the fundamental mechanisms that drive the evolution of attitudes, beliefs and behaviour within social groups. Homophily relates the similarity between pairs of individuals' attitudinal states to their…

Physics and Society · Physics 2015-06-12 Jonathan Ward , Peter Grindrod

It is well established that gene expression can be modeled as a Markovian stochastic process and hence proper observables might be subjected to large fluctuations and rare events. Since dynamics is often more than statics, one can work with…

Biological Physics · Physics 2019-09-11 Pegah Torkaman , Farhad H. Jafarpour

We consider a mathematical model for the evolutionary dynamics of tumour cells in vascularised tumours under chemotherapy. The model comprises a system of coupled partial integro-differential equations for the phenotypic distribution of…

Tissues and Organs · Quantitative Biology 2020-06-02 Chiara Villa , Mark A. J. Chaplain , Tommaso Lorenzi

We consider stationary stochastic dynamical systems evolving on a compact metric space, by perturbing a deterministic dynamics with a random noise, added according to an arbitrary probabilistic distribution. We prove the maximal and…

Dynamical Systems · Mathematics 2018-07-10 Eleonora Catsigeras

Recent \emph{in vivo} experiments have illustrated the importance of understanding the hemodynamics of heart morphogenesis. In particular, ventricular trabeculation is governed by a delicate interaction between hemodynamic forces,…

Tissues and Organs · Quantitative Biology 2018-09-19 Nicholas A. Battista , Andrea N. Lane , Jiandong Liu , Laura A. Miller

We present a study demonstrating how random walk algorithms can be used for evolutionary image transition. We design different mutation operators based on uniform and biased random walks and study how their combination with a baseline…

Neural and Evolutionary Computing · Computer Science 2020-03-04 Aneta Neumann , Bradley Alexander , Frank Neumann

Many socio-economic and biological processes can be modeled as systems of interacting individuals. The behaviour of such systems can be often described within game-theoretic models. In these lecture notes, we introduce fundamental concepts…

Populations and Evolution · Quantitative Biology 2013-05-30 Jacek Miekisz

Recently, continuous-time dynamical systems, based on systems of ordinary differential equations, for mosquito populations are studied. In this paper we consider discrete-time dynamical system generated by an evolution quadratic operator of…

Dynamical Systems · Mathematics 2018-03-06 U. A. Rozikov , M. V. Velasco

Background and Objective: The role of red blood cell dynamics is emphasised in certain cardiovascular diseases, and thus needs to be closely studied. A multiphase model of blood flow allows the resolution of locally varying density of red…

Fluid Dynamics · Physics 2021-10-07 Konstantinos G. Lyras , Jack Lee

Dynamics with choice is a generalization of discrete-time dynamics where instead of the same evolution operator at every time step there is a choice of operators to transform the current state of the system. This notion is new and…

Dynamical Systems · Mathematics 2008-07-03 Lev Kapitanski , Sanja Živanović

We consider a class of cubic stochastic operators that are motivated by models for evolution of frequencies of genetic types in populations. We take populations with three mutually exclusive genetic types. The long term dynamics of single…

Dynamical Systems · Mathematics 2020-01-08 Ale Jan Homburg , Uygun Jamilov , Michael Scheutzow

A theoretical and experimental analysis is made of the effects of self-adaptation in a simple evolving system. Specifically, we consider the effects of coding the mutation and crossover probabilities of a genetic algorithm evolving in…

adap-org · Physics 2008-02-03 C. Stephens , I. Garcia , J. Mora , H. Waelbroeck

Emergence is a phenomenon taken for granted in science but also still not well understood. We have developed a model of artificial genetic evolution intended to allow for emergence on genetic, population and social levels. We present the…

Populations and Evolution · Quantitative Biology 2015-05-19 Chris Marriott , Jobran Chebib

An important component in studying mathematical models in many biochemical systems, such as those found in developmental biology, is phase transition. The purpose of this work is to analyze the phase transition property of a…

Analysis of PDEs · Mathematics 2013-12-19 Masoud Yari

A system-level genetic code is a hypothetical genetic code that exclusively or preferentially codes systems of interacting coadapted parts. System-level genetic codes differ from part-level genetic codes in which each discrete part is coded…

Adaptation and Self-Organizing Systems · Physics 2007-05-23 John F. McGowan

Phenotypes of individuals in a population of organisms are not fixed. Phenotypic fluctuations, which describe temporal variation of the phenotype of an individual or individual-to-individual variation across a population, are present in…

Populations and Evolution · Quantitative Biology 2018-08-15 Hong-Yan Shih , Harry Mickalide , David T. Fraebel , Nigel Goldenfeld , Seppe Kuehn

In one-dimensional, heterogeneous systems, the whole traffic dynamics depend strongly on the behavior of the leading vehicle. This result holds for a class of vehicular traffic models satisfying the following properties. The interactions…

Physics and Society · Physics 2021-06-03 Ricardo S. P. Lopes