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Quantitative magnetic resonance imaging might provide a more specific insight into disease process, progression and therapeutic response of multiple sclerosis. We present an extension of a previously published approach for the simultaneous…

Purpose: To improve the accuracy of multiparametric estimation, including myelin water fraction (MWF) quantification, and reduce scan time in 3D-QALAS by optimizing sequence parameters, using a self-supervised multilayer perceptron network.…

Purpose: To demonstrate the application of artificial-neural-network (ANN) for real-time processing of myelin water imaging (MWI). Methods: Three neural networks, ANN-IMWF, ANN-IGMT2, and ANN-II, were developed to generate MWI. ANN-IMWF and…

Image and Video Processing · Electrical Eng. & Systems 2019-09-20 Jieun Lee , Doohee Lee , Joon Yul Choi , Dongmyung Shin , Hyeong-Geol Shin , Jongho Lee

This paper introduces a fast, general method for dictionary-free parameter estimation in quantitative magnetic resonance imaging (QMRI) via regression with kernels (PERK). PERK first uses prior distributions and the nonlinear MR signal…

Machine Learning · Statistics 2019-06-14 Gopal Nataraj , Jon-Fredrik Nielsen , Clayton Scott , Jeffrey A. Fessler

Purpose: This study aims to develop a high-resolution whole-brain multi-parametric quantitative MRI approach for simultaneous mapping of myelin-water fraction (MWF), T1, T2, and proton-density (PD), all within a clinically feasible scan…

Quantitative magnetization transfer (qMT) imaging provides myelin-sensitive biomarkers, such as the pool size ratio (PSR), which is valuable for multiple sclerosis (MS) assessment. However, qMT requires specialized 20-30 minute scans. We…

Image and Video Processing · Electrical Eng. & Systems 2025-11-27 Jiacheng Wang , Hao Li , Xing Yao , Ahmad Toubasi , Taegan Vinarsky , Caroline Gheen , Joy Derwenskus , Chaoyang Jin , Richard Dortch , Junzhong Xu , Francesca Bagnato , Ipek Oguz

We propose a novel deep learning method which combines classical regularization with data augmentation for estimating myelin water fraction (MWF) in the brain via biexponential analysis. Our aim is to design an accurate deep learning…

Quantitative Methods · Quantitative Biology 2025-01-31 Mirage Modi , Shashank Sule , Jonathan Palumbo , Michael Rozowski , Mustapha Bouhrara , Wojciech Czaja , Richard G. Spencer

In recent years, kernel density estimation has been exploited by computer scientists to model machine learning problems. The kernel density estimation based approaches are of interest due to the low time complexity of either O(n) or…

Machine Learning · Statistics 2007-10-16 Yen-Jen Oyang , Darby Tien-Hao Chang , Yu-Yen Ou , Hao-Geng Hung , Chih-Peng Wu , Chien-Yu Chen

In this paper we investigate the performance of different machine learning potentials (MLPs) in predicting key thermodynamic properties of water using RPBE+D3. Specifically, we scrutinize kernel-based regression and high-dimensional neural…

In this paper we introduce an efficient method to unwrap multi-frequency phase estimates for time-of-flight ranging. The algorithm generates multiple depth hypotheses and uses a spatial kernel density estimate (KDE) to rank them. The…

Computer Vision and Pattern Recognition · Computer Science 2016-08-19 Felix Järemo Lawin , Per-Erik Forssén , Hannes Ovrén

This paper presents new methodology for computationally efficient kernel density estimation. It is shown that a large class of kernels allows for exact evaluation of the density estimates using simple recursions. The same methodology can be…

Computation · Statistics 2019-11-12 David P. Hofmeyr

In contrast to current state-of-the-art methods, such as NSFP [25], which employ deep implicit neural functions for modeling scene flow, we present a novel approach that utilizes classical kernel representations. This representation enables…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Xueqian Li , Simon Lucey

Kernel density estimation and kernel regression are powerful but computationally expensive techniques: a direct evaluation of kernel density estimates at $M$ evaluation points given $N$ input sample points requires a quadratic…

Computation · Statistics 2020-02-18 Nicolas Langrené , Xavier Warin

White matter hyperintensities (WMH) are bright regions on T2-weighted magnetic resonance imaging (MRI) scans and are associated with cerebrovascular pathology and neurodegeneration, including myelin loss. While Luxol Fast Blue…

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). A reliable measure of the tissue myelin content is therefore essential for the understanding of the physiopathology of MS, tracking progression and…

Computer Vision and Pattern Recognition · Computer Science 2018-09-17 Wen Wei , Emilie Poirion , Benedetta Bodini , Stanley Durrleman , Nicholas Ayache , Bruno Stankoff , Olivier Colliot

Multithreshold Entropy Linear Classifier (MELC) is a density based model which searches for a linear projection maximizing the Cauchy-Schwarz Divergence of dataset kernel density estimation. Despite its good empirical results, one of its…

Machine Learning · Computer Science 2015-04-21 Rafal Jozefowicz , Wojciech Marian Czarnecki

Background: Quantitative stress perfusion cardiovascular magnetic resonance (CMR) is a powerful tool for assessing myocardial ischemia. Motion correction is essential for accurate pixel-wise mapping but traditional registration-based…

Computer Vision and Pattern Recognition · Computer Science 2025-10-02 Noortje I. P. Schueler , Nathan C. K. Wong , Richard J. Crawley , Josien P. W. Pluim , Amedeo Chiribiri , Cian M. Scannell

A new technique for on-line high resolution isotopic analysis of liquid water, tailored for ice core studies is presented. We built an interface between a Wavelength Scanned Cavity Ring Down Spectrometer (WS-CRDS) purchased from Picarro…

Instrumentation and Detectors · Physics 2014-04-24 V. Gkinis , T. J. Popp , T. Blunier , M. Bigler , S. Schüpbach , E. Kettner , S. J. Johnsen

Kernel density estimation (KDE) is one of the most widely used nonparametric density estimation methods. The fact that it is a memory-based method, i.e., it uses the entire training data set for prediction, makes it unsuitable for most…

Machine Learning · Computer Science 2022-08-08 Joseph A. Gallego , Juan F. Osorio , Fabio A. González

Purpose: To develop a technique for joint measurement of fat and water-specific longitudinal relaxation rates (R1f and R1w), effective transverse relaxation rate (R2*), and proton density fat fraction (PDFF) combining the Multi-Echo…

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