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The spiked covariance model has gained increasing popularity in high-dimensional data analysis. A fundamental problem is determination of the number of spiked eigenvalues, $K$. For estimation of $K$, most attention has focused on the use of…

Methodology · Statistics 2021-01-07 Zheng Tracy Ke , Yucong Ma , Xihong Lin

In this paper, a mixed-effect modeling scheme is proposed to construct a predictor for different features of cancer tumor. For this purpose, a set of features is extracted from two groups of patients with the same type of cancer but with…

Applications · Statistics 2018-04-13 Fatemeh Nasiri , Oscar Acosta-Tamayo

Much research has been carried out on shrinkage methods for real-valued covariance matrices. In spectral analysis of $p$-vector-valued time series there is often a need for good shrinkage methods too, most notably when the complex-valued…

Statistics Theory · Mathematics 2015-10-28 A. T. Walden , D. Schneider-Luftman

While multiple testing procedures have been the focus of much statistical research, an important facet of the problem is how to deal with possible confounding. Procedures have been developed by authors in genetics and statistics. In this…

Methodology · Statistics 2008-12-18 Debashis Ghosh

The mean-variance model remains the most prevalent investment framework, built on diversification principles. However, it consistently struggles with estimation errors in expected returns and the covariance matrix, its core parameters. To…

Portfolio Management · Quantitative Finance 2026-01-29 Rupendra Yadav , Amita Sharma , Aparna Mehra

In this paper, new results in random matrix theory are derived which allow us to construct a shrinkage estimator of the global minimum variance (GMV) portfolio when the shrinkage target is a random object. More specifically, the shrinkage…

Statistical Finance · Quantitative Finance 2023-04-19 Taras Bodnar , Nestor Parolya , Erik Thorsen

In Bayesian regression models with categorical predictors, constraints are needed to ensure identifiability when using all $K$ levels of a factor. The sum-to-zero constraint is particularly useful as it allows coefficients to represent…

Methodology · Statistics 2025-04-15 Zhi Ling , Shozen Dan

Estimating time-varying correlation matrices is challenging because existing methods may adapt slowly to structural changes, impose insufficient regularization, or produce diffuse posterior uncertainty. In moderate dimensions, an additional…

Methodology · Statistics 2026-05-11 Daniel Andrew Coulson , David S. Matteson , Martin T. Wells

Shrunk sample covariance matrix is a factor model of a special form combining some (typically, style) risk factor(s) and principal components with a (block-)diagonal factor covariance matrix. As such, shrinkage, which essentially inherits…

Portfolio Management · Quantitative Finance 2016-08-02 Zura Kakushadze

In this paper, we exploit the spiked covariance structure of the clutter plus noise covariance matrix for radar signal processing. Using state-of-the-art techniques high dimensional statistics, we propose a nonlinear shrinkage-based…

Signal Processing · Electrical Eng. & Systems 2023-02-07 Shashwat Jain , Vikram Krishnamurthy , Muralidhar Rangaswamy , Bosung Kang , Sandeep Gogineni

We introduce BLAST, Bayesian Linear regression with Adaptive Shrinkage for Transfer, a Bayesian multi-source transfer learning framework for high-dimensional linear regression. The proposed analytical framework leverages global-local…

Methodology · Statistics 2026-03-10 Parsa Jamshidian , Donatello Telesca

The advent of large scale, high-throughput genomic screening has introduced a wide range of tests for diagnostic purposes. Prominent among them are tests using miRNA expression levels. Genomics and proteomics now provide expression levels…

Genomics · Quantitative Biology 2016-11-08 Neerja Garikipati

In this paper, we propose the application of shrinkage strategies to estimate coefficients in the Bell regression models when prior information about the coefficients is available. The Bell regression models are well-suited for modeling…

Statistics Theory · Mathematics 2024-01-03 Solmaz Seifollahi , Hossein Bevrani , Zakariya Yahya Algamal

Sparse model estimation is a topic of high importance in modern data analysis due to the increasing availability of data sets with a large number of variables. Another common problem in applied statistics is the presence of outliers in the…

Applications · Statistics 2025-02-03 Andreas Alfons , Christophe Croux , Sarah Gelper

Evaluating treatment effect heterogeneity across patient subgroups is a fundamental aspect of clinical trial analysis. Yet, these analyses have inherent limitations due to small sample sizes and the substantial number of subgroups…

Methodology · Statistics 2026-03-24 Marcel Wolbers , Miriam Pedrera Gómez , Alex Ocampo , Isaac Gravestock

We propose a new class of estimators of the multivariate response linear regression coefficient matrix that exploits the assumption that the response and predictors have a joint multivariate Normal distribution. This allows us to indirectly…

Methodology · Statistics 2015-07-17 Aaron J. Molstad , Adam J. Rothman

Estimating the sharing of genetic effects across different conditions is important to many statistical analyses of genomic data. The patterns of sharing arising from these data are often highly heterogeneous. To flexibly model these…

Methodology · Statistics 2024-06-14 Yunqi Yang , Peter Carbonetto , David Gerard , Matthew Stephens

This manuscript presents an approach to perform generalized linear regression with multiple high dimensional covariance matrices as the outcome. Model parameters are proposed to be estimated by maximizing a pseudo-likelihood. When the data…

Methodology · Statistics 2020-07-28 Yi Zhao , Brian S. Caffo , Xi Luo

We present methods for estimating loss-based measures of the performance of a prediction model in a target population that differs from the source population in which the model was developed, in settings where outcome and covariate data are…

In this paper, we propose a scalable Bayesian method for sparse covariance matrix estimation by incorporating a continuous shrinkage prior with a screening procedure. In the first step of the procedure, the off-diagonal elements with small…

Methodology · Statistics 2023-11-22 Kyoungjae Lee , Seongil Jo , Kyeongwon Lee , Jaeyong Lee
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