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Time series segmentation aims to identify potential change-points in a sequence of temporally dependent data, so that the original sequence can be partitioned into several homogeneous subsequences. It is useful for modeling and predicting…

Computation · Statistics 2024-04-12 Shubo Sun , Zifeng Zhao , Feiyu Jiang , Xiaofeng Shao

Adaptive seamless designs combine confirmatory testing, a domain of phase III trials, with features such as treatment or subgroup selection, typically associated with phase II trials. They promise to increase the efficiency of development…

Methodology · Statistics 2019-01-25 Tim Friede , Nigel Stallard , Nicholas Parsons

An important task in early phase drug development is to identify patients, which respond better or worse to an experimental treatment. While a variety of different subgroup identification methods have been developed for the situation of…

Methodology · Statistics 2020-01-22 Marius Thomas , Björn Bornkamp , Heidi Seibold

The use of unsupervised learning to identify patient subgroups has emerged as a potentially promising direction to improve the efficiency of Intensive Care Units (ICUs). By identifying subgroups of patients with similar levels of medical…

Machine Learning · Computer Science 2024-03-06 Harry Mayne , Guy Parsons , Adam Mahdi

Subgroup analysis of treatment effects plays an important role in applications from medicine to public policy to recommender systems. It allows physicians (for example) to identify groups of patients for whom a given drug or treatment is…

Machine Learning · Statistics 2020-10-20 Hyun-Suk Lee , Yao Zhang , William Zame , Cong Shen , Jang-Won Lee , Mihaela van der Schaar

We introduce profile matching, a multivariate matching method for randomized experiments and observational studies that finds the largest possible unweighted samples across multiple treatment groups that are balanced relative to a covariate…

Methodology · Statistics 2022-07-07 Eric R. Cohn , Jose R. Zubizarreta

Many massive data are assembled through collections of information of a large number of individuals in a population. The analysis of such data, especially in the aspect of individualized inferences and solutions, has the potential to create…

Methodology · Statistics 2019-09-18 Chencheng Cai , Rong Chen , Min-ge Xie

Pharmaceutical companies continue to seek innovative ways to explore whether a drug under development is likely to be suitable for all or only an identifiable stratum of patients in the target population. The sooner this can be done during…

Methodology · Statistics 2019-12-10 Thomas O. Jemielita , Devan V. Mehrotra

Integrating multiple observational studies for meta-analysis has sparked much interest. The presented R package WMAP (Weighted Meta-Analysis with Pseudo-Population) addresses a critical gap in the implementation of integrative weighting…

Methodology · Statistics 2025-07-01 Subharup Guha , Mengqi Xu , Kashish Priyam , Yi Li

Package-to-group recommender systems recommend a set of unified items to a group of people. Different from conventional settings, it is not easy to measure the utility of group recommendations because it involves more than one user. In…

Information Retrieval · Computer Science 2021-12-30 Ryoma Sato

Subgroup selection in clinical trials is essential for identifying patient groups that react differently to a treatment, thereby enabling personalised medicine. In particular, subgroup selection can identify patient groups that respond…

Subgroup analyses of randomized controlled trials (RCTs) constitute an important component of the drug development process in precision medicine. In particular, subgroup analyses of early-stage trials often influence the design and…

Methodology · Statistics 2025-02-12 Daniel Schwartz , Riddhiman Saha , Steffen Ventz , Lorenzo Trippa

Fairness is a growing area of machine learning (ML) that focuses on ensuring models do not produce systematically biased outcomes for specific groups, particularly those defined by protected attributes such as race, gender, or age.…

Computation · Statistics 2025-10-14 Benjamin Smith , Jianhui Gao , Jessica Gronsbell

Person re-identification (ReId), a crucial task in surveillance, involves matching individuals across different camera views. The advent of Deep Learning, especially supervised techniques like Convolutional Neural Networks and Attention…

Computer Vision and Pattern Recognition · Computer Science 2025-10-27 Andrea Asperti , Salvatore Fiorilla , Simone Nardi , Lorenzo Orsini

With the timely formation of personalized intervention plans based on high-dimensional heterogeneous time series information becoming an important challenge in the medical field today, electronic medical records, wearables, and other…

Artificial Intelligence · Computer Science 2025-04-29 Dingxin Lu , Shurui Wu , Xinyi Huang

Grouping patients meaningfully can give insights about the different types of patients, their needs, and the priorities. Finding groups that are meaningful is however very challenging as background knowledge is often required to determine…

Databases · Computer Science 2019-04-04 Seyed Amin Tabatabaei , Xixi Lu , Mark Hoogendoorn , Hajo A. Reijers

Recent advances in big data and analytics research have provided a wealth of large data sets that are too big to be analyzed in their entirety, due to restrictions on computer memory or storage size. New Bayesian methods have been developed…

Applications · Statistics 2014-09-30 Alexey Miroshnikov , Erin Conlon

Inference in clustering is paramount to uncovering inherent group structure in data. Clustering methods which assess statistical significance have recently drawn attention owing to their importance for the identification of patterns in high…

Methodology · Statistics 2021-06-18 Debora Zava Bello , Marcio Valk , Gabriela Bettella Cybis

Personalized diagnoses have not been possible due to sear amount of data pathologists have to bear during the day-to-day routine. This lead to the current generalized standards that are being continuously updated as new findings are…

Computer Vision and Pattern Recognition · Computer Science 2021-10-27 Jialun Wu , Zeyu Gao , Haichuan Zhang , Ruonan Zhang , Tieliang Gong , Chunbao Wang , Chen Li

We present an end-to-end methodological framework for causal segment discovery that aims to uncover differential impacts of treatments across subgroups of users in large-scale digital experiments. Building on recent developments in causal…

Methodology · Statistics 2021-11-03 Nima S. Hejazi , Wenjing Zheng , Sathya Anand