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Critical sized bone defects remain a major clinical challenge, requiring scaffolds that combine mechanical stability with regenerative capacity. Functionally graded (FG) scaffolds, inspired by the graded architecture of native bone, offer a…

Computational Physics · Physics 2025-11-04 Ali Entezari , Vahid Badali , Sara Checa

In traditional topology optimization, the computing time required to iteratively update the material distribution within a design domain strongly depends on the complexity or size of the problem, limiting its application in real engineering…

Computational Engineering, Finance, and Science · Computer Science 2024-05-14 Gabriel Garayalde , Matteo Torzoni , Matteo Bruggi , Alberto Corigliano

We present a multi-phase design parameterization to obtain optimized heterogeneous lattice structures. The 3D domain is discretized into a cubical grid wherein each cube has eight distinct unit cell types or phases. When all phases are…

Materials Science · Physics 2021-03-04 Yash Agrawal , G. K. Ananthasuresh

An important step in shape optimization with partial differential equation constraints is to adapt the geometry during each optimization iteration. Common strategies are to employ mesh-deformation or re-meshing, where one or the other…

Numerical Analysis · Mathematics 2018-06-27 Jorgen S. Dokken , Simon W. Funke , August Johansson , Stephan Schmidt

The structural design process for buildings is time-consuming and laborious. To automate this process, structural engineers combine optimization methods with simulation tools to find an optimal design with minimal building mass subject to…

Machine Learning · Computer Science 2020-08-14 Kai-Hung Chang , Chin-Yi Cheng

A design problem of finding an optimally stiff membrane structure by selecting one-dimensional fiber reinforcements is formulated and solved. The membrane model is derived in a novel manner from a particular three-dimensional linear elastic…

Numerical Analysis · Mathematics 2016-09-13 Anders Klarbring , Bo Torstenfelt , Peter Hansbo , Mats G. Larson

Mechanical properties of the tissue engineering scaffolds are known to play a crucial role in tissue regeneration. Here, we have utilized discrete network and finite element models to study fibrous scaffold mechanics and its dependence on…

Soft Condensed Matter · Physics 2025-01-15 Dhruba Jyoti Mech , Mohd Suhail Rizvi

Stochastic programming can be applied to consider uncertainties in energy system optimization models for capacity expansion planning. However, these models become increasingly large and time-consuming to solve, even without considering…

Optimization and Control · Mathematics 2025-08-15 Shima Sasanpour , Manuel Wetzel , Karl-Kiên Cao , Hans Christian Gils , Andrés Ramos

The paper presents a topology optimization approach that designs an optimal structure, called a self-supporting structure, which is ready to be fabricated via additive manufacturing without the usage of additional support structures. Such…

Computational Engineering, Finance, and Science · Computer Science 2017-08-25 Dengyang Zhao , Ming Li , Yusheng Liu

We present a two-scale topology optimization framework for the design of macroscopic bodies with an optimized elastic response, which is achieved by means of a spatially-variant cellular architecture on the microscale. The chosen spinodoid…

Computational Engineering, Finance, and Science · Computer Science 2021-05-21 Li Zheng , Siddhant Kumar , Dennis M. Kochmann

Motivated by an application involving additively manufactured bioresorbable polymer scaffolds supporting bone tissue regeneration, we investigate the impact of uncertain geometry perturbations on the effective mechanical properties of…

Analysis of PDEs · Mathematics 2023-04-19 Patrick Dondl , Yongming Luo , Stefan Neukamm , Steve Wolff-Vorbeck

This work presents a rigorous mathematical formulation for topology optimization of a macrostructure undergoing ductile failure. The prediction of ductile solid materials which exhibit dominant plastic deformation is an intriguingly…

Numerical Analysis · Mathematics 2023-03-22 Nima Noii , Hassan Ali Jahangiry , Haim Waisman

We introduce the isogeometric shape optimisation of thin shell structures using subdivision surfaces. Both triangular Loop and quadrilateral Catmull-Clark subdivision schemes are considered for geometry modelling and finite element…

Numerical Analysis · Mathematics 2019-05-21 Kosala Bandara , Fehmi Cirak

To solve large-scale or high-resolution topology optimization problem, a novel algorithm is developed based on modified bi-directional evolutionary structure optimization (BESO) and extended finite element method (XFEM). Within XFEM, a set…

Applied Physics · Physics 2026-04-07 Hongxin Wang , Jie Liu , Guilin Wen

The work explores a specific scenario for structural computational optimization based on the following elements: (a) a relaxed optimization setting considering the ersatz (bi-material) approximation, (b) a treatment based on a nonsmoothed…

Computational Engineering, Finance, and Science · Computer Science 2021-08-06 J. Oliver , D. Yago , J. Cante , O. Lloberas-Valls

Phase separation within polymer networks plays a central role in shaping the structure and mechanics of both synthetic materials and living cells, including the formation of biomolecular condensates within cytoskeletal networks. Previous…

Soft Condensed Matter · Physics 2025-12-01 Takahiro Yokoyama , Yicheng Qiang , David Zwicker , Arash Nikoubashman

The regeneration of the ruptured scapholunate interosseous ligament (SLIL) represents a clinical challenge. Here, we propose the use of a Bone-Ligament-Bone (BLB) 3D-printed polyethylene terephthalate (PET) scaffold for achieving mechanical…

A shape optimization problem arising from the optimal reinforcement of a membrane by means of one-dimensional stiffeners or from the fastest cooling of a two-dimensional object by means of ``conducting wires'' is considered. The criterion…

Analysis of PDEs · Mathematics 2020-07-14 Giuseppe Buttazzo , Francesco Paolo Maiale

We propose a solution strategy for a multimaterial minimum compliance topology optimization problem, which consists in finding the optimal allocation of a finite number of candidate (possibly anisotropic) materials inside a reference…

Numerical Analysis · Mathematics 2018-07-04 Francesco Regazzoni , Nicola Parolini , Marco Verani

We consider shape optimization problems for elasticity systems in architecture. A typical question in this context is to identify a structure of maximal stability close to an initially proposed one. We show the existence of such an…