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Regular firing neurons can be seen as oscillators. The phase-response curve (PRC) describes how such neurons will respond to small excitatory perturbations. Knowledge of the PRC is important as it is associated to the excitability type of…

Neurons and Cognition · Quantitative Biology 2010-01-05 Benjamin Torben-Nielsen , Marylka Uusisaari , Klaus M. Stiefel

Phase response curve (PRC) is an extremely useful tool for studying the response of oscillatory systems, e.g. neurons, to sparse or weak stimulation. Here we develop a framework for studying the response to a series of pulses which are…

Data Analysis, Statistics and Probability · Physics 2017-09-13 Vladimir Klinshov , Serhiy Yanchuk , Artur Stephan , Vladimir Nekorkin

The phase sensitivity curve or phase response curve (PRC) quantifies the oscillator's reaction to stimulation at a specific phase and is a primary characteristic of a self-sustained oscillatory unit. Knowledge of this curve yields a phase…

Adaptation and Self-Organizing Systems · Physics 2022-12-08 Rok Cestnik , Erik T. K. Mau , Michael Rosenblum

The phase-response curve (PRC) is an important tool to determine the excitability type of single neurons which reveals consequences for their synchronizing properties. We review five methods to compute the PRC from both model data and…

Quantitative Methods · Quantitative Biology 2010-03-29 Benjamin Torben-Nielsen , Marylka Uusisaari , Klaus M. Stiefel

At the level of individual neurons, various coding properties can be inferred from the input-output relationship of a cell. For small inputs, this relation is captured by the phase-response curve (PRC), which measures the effect of a small…

Neurons and Cognition · Quantitative Biology 2026-01-14 Janina Hesse , Susanne Schreiber

The "Phase Response Curve" (PRC) is a common tool used to analyze phase resetting in the natural sciences. We make the observation that the PRC with respect to a coordinate $y\in\mathbb{R}$ actually depends on the full choice of coordinates…

Quantitative Methods · Quantitative Biology 2021-11-15 Simon Wilshin , Matthew D. Kvalheim , Shai Revzen

The phase response curve (PRC) is an important measure representing the interaction between oscillatory elements. To understand synchrony in biological systems, many research groups have sought to measure PRCs directly from biological cells…

Quantitative Methods · Quantitative Biology 2015-08-03 Kazuhiko Morinaga , Ryota Miyata , Toru Aonishi

Perturbation theory is an important tool in the analysis of oscillators and their response to external stimuli. It is predicated on the assumption that the perturbations in question are "sufficiently weak", an assumption that is not always…

Neurons and Cognition · Quantitative Biology 2012-01-19 Kevin K. Lin , Kyle C. A. Wedgwood , Stephen Coombes , Lai-Sang Young

The phase-resetting curve (PRC) describes the response of a neural oscillator to small perturbations in membrane potential. Its usefulness for predicting the dynamics of weakly coupled deterministic networks has been well characterized.…

Dynamical Systems · Mathematics 2015-05-13 Aushra Abouzeid , Bard Ermentrout

Brain rhythms emerge as a result of synchronization among interconnected spiking neurons. Key properties of such rhythms can be gleaned from the phase-resetting curve (PRC). Inferring the macroscopic PRC and developing a systematic phase…

Neurons and Cognition · Quantitative Biology 2022-10-12 Gregory Dumont , Alberto Pérez-Cervera , Boris Gutkin

Synchronized neural spiking is associated with many cognitive functions and thus, merits study for its own sake. The analysis of neural synchronization naturally leads to the study of repetitive spiking and consequently to the analysis of…

Neurons and Cognition · Quantitative Biology 2017-07-19 Youngmin Park , Stewart Heitmann , G. Bard Ermentrout

When dynamical systems that produce rhythmic behaviors operate within hard limits, they may exhibit limit cycles with sliding components, that is, closed isolated periodic orbits that make and break contact with a constraint surface.…

Dynamical Systems · Mathematics 2020-11-03 Yangyang Wang , Jeffrey P. Gill , Hillel J. Chiel , Peter J. Thomas

The asymptotic phase $\theta$ of an initial point $x$ in the stable manifold of a limit cycle identifies the phase of the point on the limit cycle to which the flow $\phi_t(x)$ converges as $t\to\infty$. The infinitesimal phase response…

Dynamical Systems · Mathematics 2018-04-13 Youngmin Park , Kendrick M. Shaw , Hillel J. Chiel , Peter J. Thomas

We prove that a group of injection-locked oscillators, each modelled using a nonlinear phase macromodel, responds as a single oscillator to small external perturbations. More precisely, we show that any group of injection-locked oscillators…

Chaotic Dynamics · Physics 2012-09-11 Jaijeet Roychowdhury

Anticipated synchronization (AS) is a counter intuitive behavior that has been observed in several systems. When AS establishes in a sender-receiver configuration, the latter can predict the future dynamics of the former for certain…

Neurons and Cognition · Quantitative Biology 2017-05-31 Fernanda S. Matias , Pedro V. Carelli , Claudio R. Mirasso , Mauro Copelli

Many real oscillators are coupled to other oscillators and the coupling can affect the response of the oscillators to stimuli. We investigate phase response curves (PRCs) of coupled oscillators. The PRCs for two weakly coupled phase-locked…

Neurons and Cognition · Quantitative Biology 2009-11-13 Tae-Wook Ko , Bard Ermentrout

Phase resetting is a common experimental approach to investigating the behaviour of oscillating neurons. Assuming repeated spiking or bursting, a phase reset amounts to a brief perturbation that causes a shift in the phase of this periodic…

Dynamical Systems · Mathematics 2020-03-17 Peter Langfield , Bernd Krauskopf , Hinke M. Osinga

Longitudinal and high-dimensional measurements have become increasingly common in biomedical research. However, methods to predict survival outcomes using covariates that are both longitudinal and high-dimensional are currently missing. In…

We investigate the phase response properties of the Hindmarsh-Rose model of neuronal bursting using burst phase response curves (BPRCs) computed with an infinitesimal perturbation approximation and by direct simulation of synaptic input.…

Dynamical Systems · Mathematics 2009-10-13 William Erik Sherwood , John Guckenheimer

In this paper we use the parameterization method to provide a complete description of the dynamics of an $n$-dimensional oscillator beyond the classical phase reduction. The parameterization method allows, via efficient algorithms, to…

Dynamical Systems · Mathematics 2021-01-22 Alberto Pérez-Cervera , Tere M. Seara , Gemma Huguet
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