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The brain is immensely complex, with diverse components and dynamic interactions building upon one another to orchestrate a wide range of functions and behaviors. Understanding patterns of these complex interactions and how they are…

Neurons and Cognition · Quantitative Biology 2024-08-06 Suman Kulkarni , Dani S. Bassett

Predicting how the brain can be driven to specific states by means of internal or external control requires a fundamental understanding of the relationship between neural connectivity and activity. Network control theory is a powerful tool…

Neurons and Cognition · Quantitative Biology 2019-08-12 Teresa M. Karrer , Jason Z. Kim , Jennifer Stiso , Ari E. Kahn , Fabio Pasqualetti , Ute Habel , Danielle S. Bassett

The brain is an intricately structured organ responsible for the rich emergent dynamics that support the complex cognitive functions we enjoy as humans. With around $10^{11}$ neurons and $10^{15}$ synapses, understanding how the human brain…

Neurons and Cognition · Quantitative Biology 2019-02-12 Jason Z. Kim , Danielle S. Bassett

Cognition is supported by neurophysiological processes that occur both in local anatomical neighborhoods and in distributed large-scale circuits. Recent evidence from network control theory suggests that white matter pathways linking…

Neurons and Cognition · Quantitative Biology 2016-06-30 John D. Medaglia , Shi Gu , Fabio Pasqualetti , Rebecca L. Ashare , Caryn Lerman , Joseph Kable , Danielle S. Bassett

The human brain is a complex network that supports mental function. The nascent field of network neuroscience applies tools from mathematics to neuroimaging data in the hopes of shedding light on cognitive function. A critical question…

Neurons and Cognition · Quantitative Biology 2017-04-26 John D. Medaglia , Perry Zurn , Walter Sinnott-Armstrong , Danielle S. Bassett

The ability to effectively control brain dynamics holds great promise for the enhancement of cognitive function in humans, and the betterment of their quality of life. Yet, successfully controlling dynamics in neural systems is challenging,…

Quantitative Methods · Quantitative Biology 2018-08-29 Evelyn Tang , Danielle S. Bassett

Network control theory has recently emerged as a promising approach for understanding brain function and dynamics. By operationalizing notions of control theory for brain networks, it offers a fundamental explanation for how brain dynamics…

Quantitative Methods · Quantitative Biology 2020-03-20 Shikuang Deng , Shi Gu

Cognitive function is driven by dynamic interactions between large-scale neural circuits or networks, enabling behavior. Fundamental principles constraining these dynamic network processes have remained elusive. Here we use network control…

Neurons and Cognition · Quantitative Biology 2015-10-28 Shi Gu , Fabio Pasqualetti , Matthew Cieslak , Scott T. Grafton , Danielle S. Bassett

The brain is a highly complex organ consisting of a myriad of subsystems that flexibly interact and adapt over time and context to enable perception, cognition, and behavior. Understanding the multi-scale nature of the brain, i.e., how…

Neurons and Cognition · Quantitative Biology 2025-01-17 Adam S. Charles

Objective: Brain is a fantastic organ that helps creature adapting to the environment. Network is the most essential structure of brain, but the capability of a simple network is still not very clear. In this study, we try to expound some…

Neurons and Cognition · Quantitative Biology 2019-11-05 Xiang Zou , Lie Yao , Donghua Zhao , Liang Chen , Ying Mao

Graph theory is now becoming a standard tool in system-level neuroscience. However, endowing observed brain anatomy and dynamics with a complex network structure does not entail that the brain actually works as a network. Asking whether the…

Neurons and Cognition · Quantitative Biology 2024-12-24 D. Papo , J. M. Buldú

A fundamental understanding of the network architecture of the brain is necessary for the further development of theories explicating circuit function. Perhaps as a derivative of its initial application to abstract informational systems,…

Neurons and Cognition · Quantitative Biology 2018-07-13 Jennifer Stiso , Danielle Bassett

The brain is a complex system comprising a myriad of interacting elements, posing significant challenges in understanding its structure, function, and dynamics. Network science has emerged as a powerful tool for studying such intricate…

What is the relationship between brain and behavior? The answer to this question necessitates characterizing the mapping between structure and function. The aim of this paper is to discuss broad issues surrounding the link between structure…

Neurons and Cognition · Quantitative Biology 2015-06-19 Luiz Pessoa

The question of controllability of natural and man-made network systems has recently received considerable attention. In the context of the human brain, the study of controllability may not only shed light into the organization and function…

Optimization and Control · Mathematics 2021-02-10 Tommaso Menara , Shi Gu , Danielle S. Bassett , Fabio Pasqualetti

The relationship between brain structure and function has been probed using a variety of approaches, but how the underlying structural connectivity of the human brain drives behavior is far from understood. To investigate the effect of…

Neurons and Cognition · Quantitative Biology 2018-11-15 Kanika Bansal , John D. Medaglia , Danielle S. Bassett , Jean M. Vettel , Sarah F. Muldoon

Recent advances in computational models of signal propagation and routing in the human brain have underscored the critical role of white matter structure. A complementary approach has utilized the framework of network control theory to…

Neurons and Cognition · Quantitative Biology 2021-03-15 Pragya Srivastava , Erfan Nozari , Jason Z. Kim , Harang Ju , Dale Zhou , Cassiano Becker , Fabio Pasqualetti , Danielle S. Bassett

The brain can be considered as a system that dynamically optimizes the structure of anatomical connections based on the efficiency requirements of functional connectivity. To illustrate the power of this principle in organizing the…

Neurons and Cognition · Quantitative Biology 2024-02-07 Carlos Calvo Tapia , Valeriy A. Makarov Slizneva , Cees van Leeuwen

The brain is an assembly of neuronal populations interconnected by structural pathways. Brain activity is expressed on and constrained by this substrate. Therefore, statistical dependencies between functional signals in directly connected…

Neurons and Cognition · Quantitative Biology 2019-09-11 Maria Giulia Preti , Dimitri Van De Ville

Intrinsic brain activity is characterized by highly structured co-activations between different regions, whose origin is still under debate. In this paper, we address the question whether it is possible to unveil how the underlying…

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