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Modeling the relationship between chemical structure and molecular activity is a key goal in drug development. Many benchmark tasks have been proposed for molecular property prediction, but these tasks are generally aimed at specific,…

Quantitative Methods · Quantitative Biology 2020-10-05 Samuel G. Finlayson , Matthew B. A. McDermott , Alex V. Pickering , Scott L. Lipnick , Isaac S. Kohane

Diffusion Probabilistic Models (DPMs) have recently demonstrated impressive results on various generative tasks.Despite its promises, the learned representations of pre-trained DPMs, however, have not been fully understood. In this paper,…

Computer Vision and Pattern Recognition · Computer Science 2023-08-23 Xingyi Yang , Xinchao Wang

Deep learning is transforming many areas in science, and it has great potential in modeling molecular systems. However, unlike the mature deployment of deep learning in computer vision and natural language processing, its development in…

Computational Physics · Physics 2021-03-19 Jun Zhang , Yao-Kun Lei , Zhen Zhang , Junhan Chang , Maodong Li , Xu Han , Lijiang Yang , Yi Isaac Yang , Yi Qin Gao

The success of deep learning algorithms generally depends on large-scale data, while humans appear to have inherent ability of knowledge transfer, by recognizing and applying relevant knowledge from previous learning experiences when…

Machine Learning · Computer Science 2022-01-19 Junguang Jiang , Yang Shu , Jianmin Wang , Mingsheng Long

We propose a method to facilitate exploration and analysis of new large data sets. In particular, we give an unsupervised deep learning approach to learning a latent representation that captures semantic similarity in the data set. The core…

Computer Vision and Pattern Recognition · Computer Science 2020-12-23 Gary B Huang , Huei-Fang Yang , Shin-ya Takemura , Pat Rivlin , Stephen M Plaza

Deep learning research aims at discovering learning algorithms that discover multiple levels of distributed representations, with higher levels representing more abstract concepts. Although the study of deep learning has already led to…

Machine Learning · Computer Science 2013-06-10 Yoshua Bengio

Learning generic representations with deep networks requires massive training samples and significant computer resources. To learn a new specific task, an important issue is to transfer the generic teacher's representation to a student…

Machine Learning · Computer Science 2021-03-01 Xuhong Li , Yves Grandvalet , Rémi Flamary , Nicolas Courty , Dejing Dou

Multi-task learning can leverage information learned by one task to benefit the training of other tasks. Despite this capacity, naive formulations often degrade performance and in particular, identifying the tasks that would benefit from…

Machine Learning · Computer Science 2021-09-13 Christopher Fifty , Ehsan Amid , Zhe Zhao , Tianhe Yu , Rohan Anil , Chelsea Finn

This paper investigates the critical problem of representation similarity evolution during cross-domain transfer learning, with particular focus on understanding why pre-trained models maintain effectiveness when adapted to medical imaging…

Computer Vision and Pattern Recognition · Computer Science 2025-03-12 Wenqiang Zu , Shenghao Xie , Hao Chen , Lei Ma

Pre-training a deep neural network on the ImageNet dataset is a common practice for training deep learning models, and generally yields improved performance and faster training times. The technique of pre-training on one task and then…

Machine Learning · Computer Science 2020-01-03 Nishai Kooverjee , Steven James , Terence van Zyl

Machine-learning models in chemistry - when based on descriptors of atoms embedded within molecules - face essential challenges in transferring the quality of predictions of local electronic structures and their associated properties across…

Chemical Physics · Physics 2024-09-27 Frederik Ø. Kjeldal , Janus J. Eriksen

Time-series representation learning can extract representations from data with temporal dynamics and sparse labels. When labeled data are sparse but unlabeled data are abundant, contrastive learning, i.e., a framework to learn a latent…

Machine Learning · Computer Science 2023-03-03 Heejeong Choi , Pilsung Kang

Despite deep recurrent neural networks (RNNs) demonstrate strong performance in text classification, training RNN models are often expensive and requires an extensive collection of annotated data which may not be available. To overcome the…

Computation and Language · Computer Science 2018-10-02 Wasi Uddin Ahmad , Xueying Bai , Nanyun Peng , Kai-Wei Chang

Knowledge transfer impacts the performance of deep learning -- the state of the art for image classification tasks, including automated melanoma screening. Deep learning's greed for large amounts of training data poses a challenge for…

Computer Vision and Pattern Recognition · Computer Science 2018-03-28 Afonso Menegola , Michel Fornaciali , Ramon Pires , Flávia Vasques Bittencourt , Sandra Avila , Eduardo Valle

We propose a novel method to train deep convolutional neural networks which learn from multiple data sets of varying input sizes through weight sharing. This is an advantage in chemometrics where individual measurements represent exact…

Machine Learning · Statistics 2019-11-11 Jacob Søgaard Larsen , Line Clemmensen

How data is represented and operationalized is critical for building computational solutions that are both effective and efficient. A common approach is to represent data objects as binary vectors, denoted \textit{hash codes}, which require…

Information Retrieval · Computer Science 2021-09-07 Casper Hansen

Deep learning, a subfield of machine learning, has gained importance in various application areas in recent years. Its growing popularity has led it to enter the natural sciences as well. This has created the need for molecular…

Chemical Physics · Physics 2026-03-09 Sanjanasri JP , Pratiti Bhadra , N. Sukumar , Soman KP

Sharing knowledge between tasks is vital for efficient learning in a multi-task setting. However, most research so far has focused on the easier case where knowledge transfer is not harmful, i.e., where knowledge from one task cannot…

Machine Learning · Computer Science 2019-07-08 Timo Bram , Gino Brunner , Oliver Richter , Roger Wattenhofer

A key element in transfer learning is representation learning; if representations can be developed that expose the relevant factors underlying the data, then new tasks and domains can be learned readily based on mappings of these salient…

Machine Learning · Computer Science 2014-12-18 Yujia Li , Kevin Swersky , Richard Zemel

Self-supervised representation learning methods aim to provide powerful deep feature learning without the requirement of large annotated datasets, thus alleviating the annotation bottleneck that is one of the main barriers to practical…

Machine Learning · Computer Science 2022-05-18 Linus Ericsson , Henry Gouk , Chen Change Loy , Timothy M. Hospedales
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