Related papers: Fingering instabilities in tissue invasion: an act…
Many physical systems are well described on domains which are relatively large in some directions but relatively thin in other directions. In this scenario we typically expect the system to have emergent structures that vary slowly over the…
Viscous fingering (VF) is an interfacial instability that occurs in a narrow confinement or porous medium when a less-viscous fluid pushes a more viscous one, producing finger-like patterns. Controlling the VF instability is essential to…
The rheological properties of biological tissues are core to processes such as cancer metastasis, wound healing and embryo development. The emergence of tissue and organ structures during morphogenesis requires the precise formation of…
As biomedical sciences discover new layers of complexity in the mechanisms of life and disease, mathematical models trying to catch up with these developments become mathematically intractable. As a result, in the grand scheme of things,…
We propose a diffuse interface model to describe tumor as a multicomponent deformable porous medium. We include mechanical effects in the model by coupling the mass balance equations for the tumor species and the nutrient dynamics to a…
Cancer is a disease that takes millions of lives every year. Then, to propose treatments, avoid recurrence, and improve the patient's life quality, we need to analyze this disease from a biophysical perspective with a solid mathematical…
Collective migration dominates many phenomena, from cell movement in living systems to abiotic self-propelling particles. Focusing on the early stages of tumor evolution, we enunciate the principles involved in cell dynamics and highlight…
Models for fluid deformable surfaces provide valid theories to describe the dynamics of thin fluidic sheets of soft materials. To use such models in morphogenesis and development requires to incorporate active forces. We consider active…
We investigate the formation of fingered flow in dry granular media under simulated rainfall using a quasi-2D experimental set-up composed of a random close packing of mono-disperse glass beads. Using controlled experiments, we analyze the…
We study a simplified stochastic model for the vascularization of a growing tumor, incorporating the formation of new blood vessels at the tumor periphery as well as their regression in the tumor center. The resulting morphology of the…
The Saffman-Taylor viscous fingering instability occurs when a less viscous fluid displaces a more viscous one between narrowly spaced parallel plates in a Hele-Shaw cell. Experiments in radial flow geometry form fan-like patterns, in which…
A linear analysis of thermal diffusion and Maxwell equations is applied to study the thermomagnetic instability in a type-II superconducting slab. It is shown that the instability can lead to formation of spatially nonuniform distributions…
The Voronoi-based cellular model is highly successful in describing the motion of two-dimensional confluent cell tissues. In the homogeneous version of this model, the energy of each cell is determined solely by its geometric shape and…
We consider two minimal models of active fluid droplets that exhibit complex dynamics including steady motion, deformation, rotation and oscillating motion. First we consider a droplet with a concentration of active contractile matter…
Cancer cell migration between different body parts is the driving force behind cancer metastasis, which is the main cause of mortality of patients. Migration of cancer cells often proceeds by penetration through narrow cavities in locally…
We present in detail a set of algorithms to carry out fluid displacements in a dynamic pore-network model of immiscible two-phase flow in porous media. The algorithms are general and applicable to regular and irregular pore networks in two…
We deduce a model for glioma invasion making use of DTI data and accounting for the dynamics of brain tissue being actively degraded by tumor cells via excessive acidity production, but also according to the local orientation of tissue…
Knowledge regarding the kinetics of metastatic tumor formation, as related to the growth of the primary tumor, represents a fundamental issue in cancer biology. Using an in vivo mammalian model, we show here that one can obtain useful…
We present a novel flow instability that can arise in thin films of cytoskeletal fluids if the friction with the substrate on which the film lies is sufficiently strong. We consider a two dimensional, membrane-bound fragment containing…
The onset of viscous fingering in the presence of a non monotonic viscosity profile is investigated theoretically for two immiscible fluids. Classical fluid dynamics predicts that no unstable behavior may be observed when a viscous fluid…