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This paper introduces a new solution to DNA storage that integrates all three steps of retrieval, namely clustering, reconstruction, and error correction. DNA-correcting codes are presented as a unique solution to the problem of ensuring…

Information Theory · Computer Science 2024-07-02 Avital Boruchovsky , Daniella Bar-Lev , Eitan Yaakobi

Error-correcting codes over sets, with applications to DNA storage, are studied. The DNA-storage channel receives a set of sequences, and produces a corrupted version of the set, including sequence loss, symbol substitution, symbol…

Information Theory · Computer Science 2021-07-12 Hengjia Wei , Moshe Schwartz

DNA is a leading candidate as the next archival storage media due to its density, durability and sustainability. To read (and write) data DNA storage exploits technology that has been developed over decades to sequence naturally occurring…

Emerging Technologies · Computer Science 2022-05-12 Jasmine Quah , Omer Sella , Thomas Heinis

We provide an overview of current approaches to DNA-based storage system design and accompanying synthesis, sequencing and editing methods. We also introduce and analyze a suite of new constrained coding schemes for both archival and random…

Emerging Technologies · Computer Science 2015-07-08 S. M. Hossein Tabatabaei Yazdi , Han Mao Kiah , Eva Ruiz Garcia , Jian Ma , Huimin Zhao , Olgica Milenkovic

DNA-based storage is an emerging storage technology that provides high information density and long duration. Due to the physical constraints in the reading and writing processes, error correction in DNA storage poses several interesting…

Information Theory · Computer Science 2023-10-04 Jin Sima , Netanel Raviv , Moshe Schwartz , Jehoshua Bruck

In this paper we study error-correcting codes for the storage of data in synthetic deoxyribonucleic acid (DNA). We investigate a storage model where a data set is represented by an unordered set of $M$ sequences, each of length $L$. Errors…

Information Theory · Computer Science 2020-02-13 Andreas Lenz , Paul H. Siegel , Antonia Wachter-Zeh , Eitan Yaakobi

In this paper, we study error-correcting codes for the storage of data in synthetic deoxyribonucleic acid (DNA). We investigate a storage model where data is represented by an unordered set of $M$ sequences, each of length $L$. Errors…

Information Theory · Computer Science 2018-05-10 Andreas Lenz , Paul H. Siegel , Antonia Wachter-Zeh , Eitan Yaakobi

Owing to its longevity and enormous information density, DNA, the molecule encoding biological information, has emerged as a promising archival storage medium. However, due to technological constraints, data can only be written onto many…

Emerging Technologies · Computer Science 2018-03-12 Reinhard Heckel , Gediminas Mikutis , Robert N. Grass

A new family of codes, called clustering-correcting codes, is presented in this paper. This family of codes is motivated by the special structure of data that is stored in DNA-based storage systems. The data stored in these systems has the…

Information Theory · Computer Science 2019-03-12 Tal Shinkar , Eitan Yaakobi , Andreas Lenz , Antonia Wachter-Zeh

In this paper, we study achievable rates of concatenated coding schemes over a deoxyribonucleic acid (DNA) storage channel. Our channel model incorporates the main features of DNA-based data storage. First, information is stored on many,…

Information Theory · Computer Science 2020-05-04 Andreas Lenz , Lorenz Welter , Sven Puchinger

We consider a new family of codes, termed asymmetric Lee distance codes, that arise in the design and implementation of DNA-based storage systems and systems with parallel string transmission protocols. The codewords are defined over a…

Information Theory · Computer Science 2016-12-16 Ryan Gabrys , Han Mao Kiah , Olgica Milenkovic

We consider error-correcting coding for deoxyribonucleic acid (DNA)-based storage using nanopore sequencing. We model the DNA storage channel as a sampling noise channel where the input data is chunked into $M$ short DNA strands, which are…

Information Theory · Computer Science 2024-06-21 Lorenz Welter , Roman Sokolovskii , Thomas Heinis , Antonia Wachter-Zeh , Eirik Rosnes , Alexandre Graell i Amat

We study the amount of reliable information that can be stored in a DNA-based storage system with noisy sequencing, where each codeword is composed of short DNA molecules. We analyze a concatenated coding scheme, where the outer code is…

Information Theory · Computer Science 2026-05-19 Ran Tamir , Nir Weinberger , Albert Guillén i Fàbregas

DNA, with remarkable properties of high density, durability, and replicability, is one of the most appealing storage media. Emerging DNA storage technologies use composite DNA letters, where information is represented by probability…

Information Theory · Computer Science 2025-03-26 Wenkai Zhang , Zhiying Wang

DNA storage is now being considered as a new archival storage method for its durability and high information density, but still facing some challenges like high costs and low throughput. By reducing sequencing sample size for decoding…

Information Theory · Computer Science 2025-04-22 Ruiying Cao , Xin Chen

Labeling of DNA molecules is a fundamental technique for DNA visualization and analysis. This process was mathematically modeled in [1], where the received sequence indicates the positions of the used labels. In this work, we develop error…

Information Theory · Computer Science 2025-11-04 Dganit Hanania , Eitan Yaakobi

DNA codes have many applications, such as in data storage, DNA computing, etc. Good DNA codes have large sizes and satisfy some certain constraints. In this paper, we present a new construction method for reversible DNA codes. We show that…

Information Theory · Computer Science 2024-03-19 Xueyan Chen , Whan-Hyuk Choi , Hongwei Liu

We consider the problem of assembling a sequence based on a collection of its substrings observed through a noisy channel. The mathematical basis of the problem is the construction and design of sequences that may be discriminated based on…

Information Theory · Computer Science 2015-11-04 Han Mao Kiah , Gregory J. Puleo , Olgica Milenkovic

The DNA storage channel is considered, in which the $M$ Deoxyribonucleic acid (DNA) molecules comprising each codeword are stored without order, sampled $N$ times with replacement, and then sequenced over a discrete memoryless channel. For…

Information Theory · Computer Science 2022-02-15 Nir Weinberger , Neri Merhav

The DNA storage channel is considered, in which a codeword is comprised of $M$ unordered DNA molecules. At reading time, $N$ molecules are sampled with replacement, and then each molecule is sequenced. A coded-index concatenated-coding…

Information Theory · Computer Science 2022-05-23 Nir Weinberger
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