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The typical process for classifying and submitting a newly sequenced virus to the NCBI database involves two steps. First, a BLAST search is performed to determine likely family candidates. That is followed by checking the candidate…

Genomics · Quantitative Biology 2016-03-22 Troy Hernandez , Jie Yang

Viral sequence classification is an important task in pathogen detection, epidemiological surveys and evolutionary studies. Statistical learning methods are widely used to classify and identify viral sequences in samples from environments.…

Machine Learning · Computer Science 2024-05-30 Amine M. Remita , Abdoulaye Baniré Diallo

Understanding the host-specificity of different families of viruses sheds light on the origin of, e.g., SARS-CoV-2, rabies, and other such zoonotic pathogens in humans. It enables epidemiologists, medical professionals, and policymakers to…

The recent development of metagenomic sequencing makes it possible to sequence microbial genomes including viruses in an environmental sample. Identifying viral sequences from metagenomic data is critical for downstream virus analyses. The…

Genomics · Quantitative Biology 2018-06-21 Jie Ren , Kai Song , Chao Deng , Nathan A. Ahlgren , Jed A. Fuhrman , Yi Li , Xiaohui Xie , Fengzhu Sun

Viruses are submicroscopic agents that can infect all kinds of lifeforms and use their hosts' living cells to replicate themselves. Despite having some of the simplest genetic structures among all living beings, viruses are highly…

Computer Vision and Pattern Recognition · Computer Science 2024-05-27 Niloy Sikder , Md. Al-Masrur Khan , Anupam Kumar Bairagi , Mehedi Masud , Jun Jiat Tiang , Abdullah-Al Nahid

In 2022, a group of basic and clinical virologists, bioinformaticians, and evolutionary and structural biologists met in Oxford, UK, to develop a consensus on methodologies used to classify viruses. They concluded that virus taxonomy, which…

Populations and Evolution · Quantitative Biology 2023-09-26 Alexandr A. Ezhov

The aim of the study is to analyze viruses using parameters obtained from distributions of nucleotide sequences in the viral RNA. Seeking for the input data homogeneity, we analyze single-stranded RNA viruses only. Two approaches are used…

Other Quantitative Biology · Quantitative Biology 2022-04-25 Mykola Husev , Andrij Rovenchak

This work presents a new approach for classification of genomic sequences from measurements of complex networks and information theory. For this, it is considered the nucleotides, dinucleotides and trinucleotides of a genomic sequence. For…

Computational Engineering, Finance, and Science · Computer Science 2014-12-19 Bruno Mendes Moro Conque , André Yoshiaki Kashiwabara , Fabrício Martins Lopes

Recent studies reveal even the smallest genomes such as viruses evolve through complex and stochastic processes, and the assumption of independent alleles is not valid in most applications. Advances in sequencing technologies produce…

Populations and Evolution · Quantitative Biology 2017-10-30 Hyunjin Shim

Viruses represent the most abundant biological entities on Earth and play a pivotal role in microbial ecosystems, yet, as prominent human pathogens, they are closely linked to human morbidity and mortality. Accurate identification of viral…

Databases · Computer Science 2026-04-30 Wenxi Zhu , Wensheng Gan , Zhenlian Qi

Malware classification is an important and challenging problem in information security. Modern malware classification techniques rely on machine learning models that can be trained on features such as opcode sequences, API calls, and byte…

Cryptography and Security · Computer Science 2021-03-05 Aparna Sunil Kale , Fabio Di Troia , Mark Stamp

It is estimated that approximately 15% of cancers worldwide can be linked to viral infections. The viruses that can cause or increase the risk of cancer include human papillomavirus, hepatitis B and C viruses, Epstein-Barr virus, and human…

Genomics · Quantitative Biology 2023-08-30 Shorya Consul , John Robertson , Haris Vikalo

The classification of DNA sequences is a key research area in bioinformatics as it enables researchers to conduct genomic analysis and detect possible diseases. In this paper, three state-of-the-art algorithms, namely Convolutional Neural…

Other Quantitative Biology · Quantitative Biology 2020-11-03 Xiangxie Zhang , Ben Beinke , Berlian Al Kindhi , Marco Wiering

Microbial clades modeling is a challenging problem in biology based on microarray genome sequences, especially in new species gene isolates discovery and category. Marker family genome sequences play important roles in describing specific…

Quantitative Methods · Quantitative Biology 2019-04-22 Jingwei Liu

With the rapid global spread of COVID-19, more and more data related to this virus is becoming available, including genomic sequence data. The total number of genomic sequences that are publicly available on platforms such as GISAID is…

Genomics · Quantitative Biology 2021-11-16 Sarwan Ali , Murray Patterson

Motivation: Viruses represent the most abundant biological entities on the planet and play vital roles in diverse ecosystems. Cataloging viruses across various environments is essential for understanding their properties and functions.…

Genomics · Quantitative Biology 2025-04-09 Cheng Peng , Jiayu Shang , Jiaojiao Guan , Yanni Sun

Wastewater-based genomic surveillance has emerged as a powerful tool for population-level viral monitoring, offering comprehensive insights into circulating viral variants across entire communities. However, this approach faces significant…

Machine Learning · Computer Science 2025-12-04 Adele Chinda , Richmond Azumah , Hemanth Demakethepalli Venkateswara

This technical report presents a comprehensive analysis of malware classification using OpCode sequences. Two distinct approaches are evaluated: traditional machine learning using n-gram analysis with Support Vector Machine (SVM), K-Nearest…

Cryptography and Security · Computer Science 2025-04-21 Varij Saini , Rudraksh Gupta , Neel Soni

Sequence data, such as DNA, RNA, and protein sequences, exhibit intricate, multi-scale structures that pose significant challenges for conventional analysis methods, particularly those relying on alignment or purely statistical…

Genomics · Quantitative Biology 2025-10-22 Jian Liu , Li Shen , Mushal Zia , Guo-Wei Wei

Coronavirus Disease 2019 (COVID-19) demonstrated the need for accurate and fast diagnosis methods for emergent viral diseases. Soon after the emergence of COVID-19, medical practitioners used X-ray and computed tomography (CT) images of…

Image and Video Processing · Electrical Eng. & Systems 2021-01-22 Weihan Zhang , Bryan Pogorelsky , Mark Loveland , Trevor Wolf
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