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Predicting the response of a specific cancer to a therapy is a major goal in modern oncology that should ultimately lead to a personalised treatment. High-throughput screenings of potentially active compounds against a panel of genomically…

Developing nations lack adequate number of hospitals with modern equipment and skilled doctors. Hence, a significant proportion of these nations' population, particularly in rural areas, is not able to avail specialized and timely…

Computer Vision and Pattern Recognition · Computer Science 2020-03-20 Shubham Goswami , Suril Mehta , Dhruva Sahrawat , Anubha Gupta , Ritu Gupta

Problem lists are intended to provide clinicians with a relevant summary of patient medical issues and are embedded in many electronic health record systems. Despite their importance, problem lists are often cluttered with resolved or…

Information Retrieval · Computer Science 2020-08-05 Justin Lovelace , Nathan C. Hurley , Adrian D. Haimovich , Bobak J. Mortazavi

In cell line perturbation experiments, a collection of cells is perturbed with external agents (e.g. drugs) and responses such as protein expression measured. Due to cost constraints, only a small fraction of all possible perturbations can…

Applications · Statistics 2022-07-21 James P. Long , Yumeng Yang , Kim-Anh Do

Heterogeneity is a hallmark of complex diseases. Regression-based heterogeneity analysis, which is directly concerned with outcome-feature relationships, has led to a deeper understanding of disease biology. Such an analysis identifies the…

Methodology · Statistics 2022-11-29 Ziye Luo , Xinyue Yao , Yifan Sun , Xinyan Fan

The regulation of the cell state is a complex process involving several components. These complex dynamics can be modeled using Boolean networks, allowing us to explain the existence of different cell states and the transition between them.…

Molecular Networks · Quantitative Biology 2010-01-28 Elke K. Markert , Nils Baas , Arnold J. Levine , Alexei Vazquez

Training data-driven approaches for complex industrial system health monitoring is challenging. When data on faulty conditions are rare or not available, the training has to be performed in a unsupervised manner. In addition, when the…

Machine Learning · Statistics 2021-11-24 Gabriel Michau , Olga Fink

To effect behavior change a successful algorithm must make high-quality decisions in real-time. For example, a mobile health (mHealth) application designed to increase physical activity must make contextually relevant suggestions to…

Machine Learning · Statistics 2020-03-31 Marianne Menictas , Sabina Tomkins , Susan A Murphy

The design of reliable indicators to anticipate critical transitions in complex systems is an im portant task in order to detect a coming sudden regime shift and to take action in order to either prevent it or mitigate its consequences. We…

Data Analysis, Statistics and Probability · Physics 2022-12-14 Martin Heßler , Oliver Kamps

Deep Learning (DL) has been widely adopted in diverse industrial domains, including autonomous driving, intelligent healthcare, and aided programming. Like traditional software, DL systems are also prone to faults, whose malfunctioning may…

Machine Learning · Computer Science 2026-01-01 Hanmo You , Zan Wang , Zishuo Dong , Luanqi Mo , Jianjun Zhao , Junjie Chen

Balancing influential covariates is crucial for valid treatment comparisons in clinical studies. While covariate-adaptive randomization is commonly used to achieve balance, its performance can be inadequate when the number of baseline…

Methodology · Statistics 2024-12-30 Ziqing Guo , Yang Liu , Lucy Xia

The study of computing in presence of faulty robots in the Look-Compute-Move model has been the object of extensive investigation, typically with the goal of designing algorithms tolerant to as many faults as possible. In this paper, we…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-07-13 Jean-Lou De Carufel , Paola Flocchini

In this paper, a novel hybrid-degree dual estimation approach based on cubature rules and cubature-based nonlinear filters is proposed for fault diagnosis of nonlinear systems through simultaneous state and time-varying parameter…

Systems and Control · Electrical Eng. & Systems 2021-11-16 Yanyan Shen , Khashayar Khorasani

Autonomous agents based on Large Language Models (LLMs) are increasingly being utilized in complex software systems. However, reliability remains a significant challenge due to unpredictable failures such as hallucinations, execution…

Software Engineering · Computer Science 2026-05-11 Cheonsu Jeong , Younggun Shin

Background: Large-scale biological jobs on high-performance computing systems require manual intervention if one or more computing cores on which they execute fail. This places not only a cost on the maintenance of the job, but also a cost…

Distributed, Parallel, and Cluster Computing · Computer Science 2014-03-04 Blesson Varghese , Gerard McKee , Vassil Alexandrov

The growing complexity of machinery and the increasing demand for operational efficiency and safety have driven the development of advanced fault diagnosis techniques. Among these, convolutional neural networks (CNNs) have emerged as a…

The identification of a linear system model from data has wide applications in control theory. The existing work that provides finite sample guarantees for linear system identification typically uses data from a single long system…

Machine Learning · Statistics 2025-05-09 Lei Xin , Baike She , Qi Dou , George Chiu , Shreyas Sundaram

The paper continues the authors' study of the linearizability problem for nonlinear control systems. In the recent work [K. Sklyar, Systems Control Lett. 134 (2019), 104572], conditions on mappability of a nonlinear control system to a…

Optimization and Control · Mathematics 2021-01-26 Katerina V. Sklyar , Svetlana Yu. Ignatovich

In quantum engineering, faults may occur in a quantum control system, which will cause the quantum control system unstable or deteriorate other relevant performance of the system. This note presents an estimator-based fault-tolerant control…

Systems and Control · Computer Science 2018-06-13 Shi Wang , Daoyi Dong

A majority of recent advancements related to the fault diagnosis of electrical motors are based on the assumption that training and testing data are drawn from the same distribution. However, the data distribution can vary across different…

Systems and Control · Electrical Eng. & Systems 2023-08-01 Sriram Anbalagan , Deepesh Agarwal , Balasubramaniam Natarajan , Babji Srinivasan