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Cognitive function is driven by dynamic interactions between large-scale neural circuits or networks, enabling behavior. Fundamental principles constraining these dynamic network processes have remained elusive. Here we use network control…
Anatomy of the human brain constrains the formation of large-scale functional networks. Here, given measured brain activity in gray matter, we interpolate these functional signals into the white matter on a structurally-informed…
The complexity of neural dynamics stems in part from the complexity of the underlying anatomy. Yet how the organization of white matter architecture constrains how the brain transitions from one cognitive state to another remains unknown.…
Cognition is supported by neurophysiological processes that occur both in local anatomical neighborhoods and in distributed large-scale circuits. Recent evidence from network control theory suggests that white matter pathways linking…
As the human brain develops, it increasingly supports coordinated control of neural activity. The mechanism by which white matter evolves to support this coordination is not well understood. We use a network representation of diffusion…
Activity in the human brain moves between diverse functional states to meet the demands of our dynamic environment, but fundamental principles guiding these transitions remain poorly understood. Here, we capitalize on recent advances in…
The brain's functional connectivity fluctuates over time instead of remaining steady in a stationary mode even during the resting state. This fluctuation establishes the dynamical functional connectivity that transitions in a non-random…
Recent advances in computational models of signal propagation and routing in the human brain have underscored the critical role of white matter structure. A complementary approach has utilized the framework of network control theory to…
Higher brain function relies upon the ability to flexibly integrate information across specialized communities of brain regions, however it is unclear how this mechanism manifests over time. In this study, we use time-resolved network…
Electrical brain stimulation is currently being investigated as a therapy for neurological disease. However, opportunities to optimize such therapies are challenged by the fact that the beneficial impact of focal stimulation on both…
Adaptive behavior, cognition and emotion are the result of a bewildering variety of brain spatiotemporal activity patterns. An important problem in neuroscience is to understand the mechanism by which the human brain's 100 billion neurons…
Predicting how the brain can be driven to specific states by means of internal or external control requires a fundamental understanding of the relationship between neural connectivity and activity. Network control theory is a powerful tool…
The brain may be thought of as a many-body architecture with a spatio-temporal dynamics described by neuronal structures. The oscillatory nature of brain activity allows these structures (nodes) to be described as a set of coupled…
A critical mystery in neuroscience lies in determining how anatomical structure impacts the complex functional dynamics of human thought. How does large-scale brain circuitry constrain states of neuronal activity and transitions between…
Large-scale white matter pathways crisscrossing the cortex create a complex pattern of connectivity that underlies human cognitive function. Generative mechanisms for this architecture have been difficult to identify in part because little…
Network control theory has recently emerged as a promising approach for understanding brain function and dynamics. By operationalizing notions of control theory for brain networks, it offers a fundamental explanation for how brain dynamics…
The relation between large-scale brain structure and function is an outstanding open problem in neuroscience. We approach this problem by studying the dynamical regime under which realistic spatio-temporal patterns of brain activity emerge…
The human brain is composed of distinct regions that are each associated with particular functions and distinct propensities for the control of neural dynamics. However, the relation between these functions and control profiles is poorly…
Understanding the relationship between the dynamics of neural processes and the anatomical substrate of the brain is a central question in neuroscience. On the one hand, modern neuroimaging technologies, such as diffusion tensor imaging,…
Experimental fMRI studies have shown that spontaneous brain activity i.e. in the absence of any external input, exhibit complex spatial and temporal patterns of co-activity between segregated brain regions. These so-called large-scale…