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We consider the problem of sparse variable selection on high dimension heterogeneous data sets, which has been taking on renewed interest recently due to the growth of biological and medical data sets with complex, non-i.i.d. structures and…

Methodology · Statistics 2024-04-22 Hui Liu , Xiang Liu , Jing Diao , Wenting Ye , Xueling Liu , Dehui Wei

Adaptive data analysis has posed a challenge to science due to its ability to generate false hypotheses on moderately large data sets. In general, with non-adaptive data analyses (where queries to the data are generated without being…

Methodology · Statistics 2018-09-18 Preetum Nakkiran , Jarosław Błasiok

In multiple hypotheses testing it has become widely popular to make inference on the true discovery proportion (TDP) of a set $\mathcal{M}$ of null hypotheses. This approach is useful for several application fields, such as neuroimaging and…

Methodology · Statistics 2023-10-13 Friederike Preusse , Anna Vesely , Thorsten Dickhaus

This paper explores the intrinsic connections between the Bayesian false discovery rate (FDR) control procedures and their counterpart of frequentist procedures. We attempt to offer a unified view of FDR control within and beyond the…

Methodology · Statistics 2018-03-15 Xiaoquan Wen

The goal of classification with rejection is to avoid risky misclassification in error-critical applications such as medical diagnosis and product inspection. In this paper, based on the relationship between classification with rejection…

Machine Learning · Statistics 2021-09-30 Nontawat Charoenphakdee , Zhenghang Cui , Yivan Zhang , Masashi Sugiyama

Reliable semantic segmentation is essential for clinical decision making, yet deep models rarely provide explicit statistical guarantees on their errors. We introduce a simple post-hoc framework that constructs confidence masks with…

Computer Vision and Pattern Recognition · Computer Science 2025-11-20 Luca Mossina , Corentin Friedrich

In many scientific settings there is a need for adaptive experimental design to guide the process of identifying regions of the search space that contain as many true positives as possible subject to a low rate of false discoveries (i.e.…

Machine Learning · Statistics 2020-08-18 Lalit Jain , Kevin Jamieson

Hybrid controlled trials (HCTs), which augment randomized controlled trials (RCTs) with external controls (ECs), are increasingly receiving attention as a way to address limited power, slow accrual, and ethical concerns in clinical…

Methodology · Statistics 2025-05-02 Jiajun Liu , Ke Zhu , Shu Yang , Xiaofei Wang

Identifying significant sites in sequence data and analogous data is of fundamental importance in many biological fields. Fisher's exact test is a popular technique, however this approach to sparse count data is not appropriate due to…

Classification with rejection emerges as a learning paradigm which allows models to abstain from making predictions. The predominant approach is to alter the supervised learning pipeline by augmenting typical loss functions, letting model…

Machine Learning · Statistics 2025-05-09 Alexander Soen , Hisham Husain , Philip Schulz , Vu Nguyen

Prediction methods for time-to-event outcomes often utilize survival models that rely on strong assumptions about noninformative censoring or on how individual-level covariates and survival functions are related. When the main interest is…

Methodology · Statistics 2024-02-29 Mahsa Ashouri , Nicholas C. Henderson

Random forest (RF) stands out as a highly favored machine learning approach for classification problems. The effectiveness of RF hinges on two key factors: the accuracy of individual trees and the diversity among them. In this study, we…

Machine Learning · Computer Science 2024-10-28 Ye-eun Kim , Seoung Yun Kim , Hyunjoong Kim

In many scenarios such as genome-wide association studies where dependences between variables commonly exist, it is often of interest to infer the interaction effects in the model. However, testing pairwise interactions among millions of…

Methodology · Statistics 2022-09-02 Jingyi Duan , Yang Ning , Xi Chen , Yong Chen

Differential privacy provides a rigorous framework for privacy-preserving data analysis. This paper proposes the first differentially private procedure for controlling the false discovery rate (FDR) in multiple hypothesis testing. Inspired…

Statistics Theory · Mathematics 2021-07-06 Cynthia Dwork , Weijie J. Su , Li Zhang

Gradient Boosting Decision Trees (GBDTs) have become very successful in recent years, with many awards in machine learning and data mining competitions. There have been several recent studies on how to train GBDTs in the federated learning…

Machine Learning · Computer Science 2019-12-16 Qinbin Li , Zeyi Wen , Bingsheng He

We investigate the performance of a family of multiple comparison procedures for strong control of the False Discovery Rate ($\mathsf{FDR}$). The $\mathsf{FDR}$ is the expected False Discovery Proportion ($\mathsf{FDP}$), that is, the…

Statistics Theory · Mathematics 2008-11-21 Pierre Neuvial

Complex large-scale studies, such as those related to microarray data and fMRI studies, often involve testing multiple hierarchically ordered hypotheses. However, most existing false discovery rate (FDR) controlling procedures do not…

Methodology · Statistics 2016-12-15 Gavin Lynch , Wenge Guo

Refining one's hypotheses in the light of data is a common scientific practice; however, the dependency on the data introduces selection bias and can lead to specious statistical analysis. An approach for addressing this is via conditioning…

Machine Learning · Computer Science 2020-03-03 Jen Ning Lim , Makoto Yamada , Wittawat Jitkrittum , Yoshikazu Terada , Shigeyuki Matsui , Hidetoshi Shimodaira

We propose a tree regularization framework, which enables many tree models to perform feature selection efficiently. The key idea of the regularization framework is to penalize selecting a new feature for splitting when its gain (e.g.…

Machine Learning · Computer Science 2012-03-22 Houtao Deng , George Runger

To generalize deepfake detectors to future unseen forgeries, most existing methods attempt to simulate the dynamically evolving forgery types using available source domain data. However, predicting an unbounded set of future manipulations…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Ming-Hui Liu , Harry Cheng , Xin Luo , Xin-Shun Xu , Mohan S. Kankanhalli