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Fluorescence imaging allows for non-invasively visualizing and measuring key physiological parameters like pH and dissolved oxygen. In our work, we created two ratiometric fluorescent microsensors designed for accurately tracking dissolved…

Microfluidic systems with integrated sensors are ideal platforms to study and emulate processes such as complex multiphase flow and reactive transport in porous media, numerical modeling of bulk systems in medicine, and in engineering.…

A fundamental issue in biomedical and environmental sciences is the development of sensitive and robust sensors able to probe the analyte of interest, under physiological and pathological conditions or in environmental samples, and with…

Materials Science · Physics 2015-11-10 Loretta L. del Mercato , Maria Moffa , Rosaria Rinaldi , Dario Pisignano

Wearable devices are becoming increasingly important, addressing needs in both the fitness and the medical markets. In this paper, we describe a novel sensing platform based on a hollow-core polyurethane optical fiber, operating through…

Signal Processing · Electrical Eng. & Systems 2023-07-25 Alessio Stefani , Ivan D. Rukhlenko , Antoine F. J. Runge , Maryanne C. J. Large , Simon C. Fleming

Fluorescence microscopic imaging in centimeter-deep tissue has been highly sought-after for many years because much interesting in vivo micro-information, such as microcirculation, tumor angiogenesis, and metastasis, may deeply locate in…

Progress in neuroscience constantly relies on the development of new techniques to investigate the complex dynamics of neuronal networks. An ongoing challenge is to achieve minimally-invasive and high-resolution observations of neuronal…

ABSTRACT: Temperature monitoring is extremely im-portant during thermotherapy. Fiber-optic temperature sensors are preferred because of their flexibility and im-munity to electromagnetic interference. Although many types of fiber-optic…

Medical Physics · Physics 2020-02-19 Paris L. Franz , Hui Wang

Holographic wavefront manipulation enables converting hair-thin multimode optical fibres into minimally invasive lensless imaging instruments conveying much higher information densities than conventional endoscopes. Their most prominent…

Inspired by the dendritic integration and spiking operation of a biological neuron, flexible oxide-based neuron transistors gated by solid-state electrolyte films are fabricated on flexible plastic substrates for biochemical sensing…

Materials Science · Physics 2015-05-20 Ning Liu , Li Qiang Zhu , Ping Feng , Chang Jin Wan , Yang Hui Liu , Yi Shi , Qing Wan

Real-time monitoring of dynamic biological processes in the body is critical to understanding disease progression and treatment response. This data, for instance, can help address the lower than 50% response rates to cancer immunotherapy.…

We present a minimally-invasive endoscope based on a multimode fiber that combines photoacoustic and fluorescence sensing. From the measurement of a transmission matrix during a prior calibration step, a focused spot is produced and…

We report on high-temperature sensing measurements using a tubular-lattice hollow-core photonic crystal fiber displaying a microstructure formed of eight 2.4 um-thick cladding tubes. The larger thickness of our fiber's cladding tubes…

Several centimeters below the skin lie multiple biomarkers, such as glucose, oxygenation, and blood flow. Monitoring these biomarkers regularly and in a non-invasive manner would enable early insight into metabolic status and vascular…

Medical Physics · Physics 2025-10-30 Talia Xu , Caitlin Smith , Charles Lo , Jami Shepherd , Gijs van Soest , Marco Zuniga

Optical-based nanothermometry represents a transformative approach for precise temperature measurements at the nanoscale, which finds versatile applications across biology, medicine, and electronics. The assembly of ratiometric fluorescent…

Optics · Physics 2025-04-01 Mahshid Iraniparast , Nishant Kumar , Igor Sokolov

A pulse oximeter is an optical device that monitors tissue oxygenation levels. Traditionally, these devices estimate the oxygenation level by measuring the intensity of the transmitted light through the tissue and are embedded into everyday…

In this paper, we report the development of an intensity modulated fiber optic sensor for angular displacement measurement. This sensor was designed to present high sensitivity, linear response, wide bandwidth and, furthermore, to be simple…

Instrumentation and Detectors · Physics 2017-06-27 João M. S. Sakamoto , Cláudio Kitano , Gefeson M. Pacheco , Bernhard R. Tittmann

Inspired by the classic theory, we suggest that the performance of a D-shaped fiber optical surface plasmon resonance (SPR) sensor can be improved by manipulating the fiber core mode. To demonstrate this, we propose a novel fiber SPR sensor…

Applied Physics · Physics 2018-05-16 Zhixin Tan , Xuejin Li , Yuzhi Chen , Ping Fan

Nanophotonic devices excel at confining light into intense hot spots of the electromagnetic near fields, creating unprecedented opportunities for light-matter coupling and surface-enhanced sensing. Recently, all-dielectric metasurfaces with…

In this paper, we report on a multicore fiber-based (MCF) temperature sensor that operates in a wide thermal range and that is robustly packaged to withstand harsh environments. To develop the sensor, the fundamentals concerning the effect…

A high sensitivity force sensor based on dielectric microspheres in vacuum, optically trapped by a single, upward-propagating laser beam, is described. Off-axis parabolic mirrors are used both to focus the 1064~nm trapping beam and to…

Instrumentation and Detectors · Physics 2020-09-10 Akio Kawasaki , Alexander Fieguth , Nadav Priel , Charles P. Blakemore , Denzal Martin , Giorgio Gratta
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