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Infection by distinct Dengue virus serotypes and host immunity are intricately linked. In particular, certain levels of cross-reactive antibodies in the host may actually enhance infection severity leading to Dengue hemorrhagic fever (DHF).…
The 2013 outbreak of Dengue in Fiji resulted in an alarming number of deaths and has been is a matter of serious concern. Dengue fever is a disease caused by the four types of the Dengue virus serotypes and transmitted mostly from mosquito…
With approximately half of the world's population at risk of contracting dengue, this mosquito-borne disease is of global concern. International travellers significantly contribute to dengue's rapid and large-scale spread by importing the…
We investigate how key epidemiological parameters shape both seasonal epidemics and the persistence of dengue transmission. Our findings confirm known mechanistic drivers of epidemic variability and introduce a ranking of parameter…
The relationship between epidemiology, mathematical modeling and computational tools allows to build and test theories on the development and battling of a disease. This PhD thesis is motivated by the study of epidemiological models applied…
Dengue is a vector-borne disease transmitted by the mosquito Aedes aegypti. It has been observed that its incidence is strongly influenced by temperature and other abiotic factors like rainfall and humidity. In this work we compare the…
Dengue fever is increasing in geographical range, spread by invasion of its vector mosquitoes. The trade in second-hand tires has been implicated as a factor in this process as they act as mobile reservoirs of mosquito eggs and larvae.…
During the last decades, the global prevalence of dengue progressed dramatically. It is a disease which is now endemic in more than one hundred countries of Africa, America, Asia and the Western Pacific. This study addresses a mathematical…
Dengue continues to pose a major global threat, infecting nearly 390 million people annually. Recognizing the pivotal role of vector competence (vc), recent research focuses on mosquito parameters to inform transmission modeling and vector…
Dengue, which affects millions of people each year, is one of the most common diseases transmitted by infected \textit{Aedes aegypti} mosquitoes. In the Philippines, the annual economic cost of dengue infections is estimated at around PHP…
It is possible to model vector-borne infection using the classical Ross-Macdonald model. This attempt, however fails in several respects. First, using measured (or estimated) parameters, the model predicts a much greater number of cases…
We construct an epidemic model for the transmission of dengue fever with an early-life stage in the vector dynamics and age-structure within hosts. The early-life stage of the vector is modeled via a general function that supports multiple…
Identification of the influential clinical symptoms and laboratory features that help in the diagnosis of dengue fever in early phase of the illness would aid in designing effective public health management and virological surveillance…
Dengue fever is a disease which is transmitted and caused by Aedes Aegypti mosquitos. Dengue has become a serious health issue in all over the world especially in those countries who are situated in tropical or subtropical regions because…
During the last decades, the global prevalence of dengue progressed dramatically. It is a disease that is now endemic in more than one hundred countries of Africa, America, Asia, and the Western Pacific. In this paper, we present a…
The introduction of Wolbachia-carrying mosquitoes into the population has recently been proposed as an alternative strategy against dengue. Although laboratory experiments have shown that the Wolbachia bacterium can reduce the levels of…
Dengue fever is a vector-borne disease mostly endemic to tropical and subtropical countries that affect millions every year and is considered a significant burden for public health. Its geographic distribution makes it highly sensitive to…
Dengue, a mosquito-borne disease, continues to pose a persistent public health challenge in urban areas, particularly in tropical regions such as Singapore. Effective and affordable control requires anticipating where transmission risks are…
Dengue virus has caused major problems for public health officials for decades in tropical and subtropical countries. We construct a compartmental model that includes the risk of hospitalization and its impact on public health policies. The…
Controlling diseases such as dengue fever, chikungunya and zika fever by introduction of the intracellular parasitic bacterium Wolbachia in mosquito populations which are their vectors, is presently quite a promising tool to reduce their…