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Although co/multi-morbidities are associated with significant increase in mortality, the lack of appropriate quantitative exploratory techniques often impede their analysis. In the current study, we study the clustering of multimorbid…

Quantitative Methods · Quantitative Biology 2018-07-13 Shatrunjai P. Singh , Swagata Karkare , Sudhir M. Baswan , Vijendra P. Singh

Clustering multimorbidity has been a global research priority in recent years. Existing studies usually identify these clusters using one of several popular clustering methods and then explore various characteristics of these clusters,…

Applications · Statistics 2025-05-06 Sohan Seth , Nazir Lone , Niels Peek , Bruce Guthrie

In electronic health records (EHRs), clustering patients and distinguishing disease subtypes are key tasks to elucidate pathophysiology and aid clinical decision-making. However, clustering in healthcare informatics is still based on…

Machine Learning · Computer Science 2026-04-09 Manar D. Samad , Yina Hou , Shrabani Ghosh

Multimorbidity, the co-occurrence of two or more chronic diseases such as diabetes, obesity or cardiovascular diseases in one patient, is a frequent phenomenon. To make care more efficient, it is of relevance to understand how different…

Medical Physics · Physics 2019-08-05 Nils Haug , Stefan Thurner , Alexandra Kautzky-Willer , Michael Gyimesi , Peter Klimek

Through discovery of meso-scale structures, community detection methods contribute to the understanding of complex networks. Many community finding methods, however, rely on disjoint clustering techniques, in which node membership is…

Social and Information Networks · Computer Science 2022-11-23 Akhil Jakatdar , Baqiao Liu , Tandy Warnow , George Chacko

Hierarchical Agglomerative Clustering (HAC) is one of the oldest but still most widely used clustering methods. However, HAC is notoriously hard to scale to large data sets as the underlying complexity is at least quadratic in the number of…

Healthcare datasets often contain groups of highly correlated features, such as features from the same biological system. When feature selection is applied to these datasets to identify the most important features, the biases inherent in…

Machine Learning · Computer Science 2022-07-07 Annette Spooner , Gelareh Mohammadi , Perminder S. Sachdev , Henry Brodaty , Arcot Sowmya

There is a growing amount of clinical, anatomical and functional evidence for the heterogeneous presentation of neuropsychiatric and neurodegenerative diseases such as schizophrenia and Alzheimers Disease (AD). Elucidating distinct subtypes…

Machine Learning · Computer Science 2020-07-13 Junhao Wen , Erdem Varol , Ganesh Chand , Aristeidis Sotiras , Christos Davatzikos

Hierarchical Agglomerative Classification (HAC) with Ward's linkage has been widely used since its introduction in Ward (1963). The present article reviews the different extensions of the method to various input data and the constrained…

Methodology · Statistics 2019-09-25 Nathanaël Randriamihamison , Nathalie Vialaneix , Pierre Neuvial

Bayesian hierarchical clustering (BHC) is an agglomerative clustering method, where a probabilistic model is defined and its marginal likelihoods are evaluated to decide which clusters to merge. While BHC provides a few advantages over…

Machine Learning · Statistics 2015-06-04 Juho Lee , Seungjin Choi

This study investigates long-term cardiovascular complications in COVID-19 patients using advanced clustering techniques. The objective was to analyse ECG parameters, demographic data, comorbidities, and hospitalization details to identify…

Background: Identifying and characterising the longitudinal patterns of multimorbidity associated with stroke is needed to better understand patients' needs and inform new models of care. Methods: We used an unsupervised patient-oriented…

Recent years have seen an increased focus into the tasks of predicting hospital inpatient risk of deterioration and trajectory evolution due to the availability of electronic patient data. A common approach to these problems involves…

Machine Learning · Computer Science 2020-11-18 Henrique Aguiar , Mauro Santos , Peter Watkinson , Tingting Zhu

The delivery of key services in domains ranging from finance and manufacturing to healthcare and transportation is underpinned by a rapidly growing number of mission-critical enterprise applications. Ensuring the continuity of these complex…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-09-23 Premathas Somasekaram , Radu Calinescu , Rajkumar Buyya

Hierarchical Agglomerative Clustering (HAC) is an extensively studied and widely used method for hierarchical clustering in $\mathbb{R}^k$ based on repeatedly merging the closest pair of clusters according to an input linkage function $d$.…

Data Structures and Algorithms · Computer Science 2025-07-29 MohammadHossein Bateni , Laxman Dhulipala , Willem Fletcher , Kishen N Gowda , D Ellis Hershkowitz , Rajesh Jayaram , Jakub Łącki

Multimorbidity, or the presence of several medical conditions in the same individual, has been increasing in the population, both in absolute and relative terms. However, multimorbidity remains poorly understood, and the evidence from…

An agglomerative hierarchical clustering (AHC) framework and algorithm named HOSil based on a new linkage metric optimized by the average silhouette width (ASW) index is proposed. A conscientious investigation of various clustering methods…

Methodology · Statistics 2019-09-30 Fatima Batool

Our objective was to develop and test a new concept (affinity) analogous to multimorbidity of chronic conditions for individuals at census tract level in Memphis, TN. The use of affinity will improve the surveillance of multiple chronic…

Computers and Society · Computer Science 2019-11-25 Eun Kyong Shin , Youngsang Kwon , Arash Shaban-Nejad

Motivation: Genomic data analyses such as Genome-Wide Association Studies (GWAS) or Hi-C studies are often faced with the problem of partitioning chromosomes into successive regions based on a similarity matrix of high-resolution,…

Statistics Theory · Mathematics 2019-02-06 Christophe Ambroise , Alia Dehman , Pierre Neuvial , Guillem Rigaill , Nathalie Vialaneix

Hierarchical Agglomerative Clustering (HAC) is likely the earliest and most flexible clustering method, because it can be used with many distances, similarities, and various linkage strategies. It is often used when the number of clusters…

Machine Learning · Statistics 2023-09-07 Erich Schubert , Andreas Lang
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