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A major challenge in diagnosing and treating cancer is the infiltrative growth of tumors into surrounding tissues. This microscopic spread of the disease is invisible on most diagnostic imaging modalities and can often only be detected…

The derivation of suitable analytical models is an important step for the design and analysis of molecular communication systems. However, many existing models have limited applicability in practical scenarios due to various simplifications…

Emerging Technologies · Computer Science 2019-11-28 Maximilian Schäfer , Wayan Wicke , Werner Haselmayr , Rudolf Rabenstein , Robert Schober

The transport of an infinitely thin, hard rod in a random, dense array of point obstacles is investigated by molecular dynamics simulations. Our model mimics the sterically hindered dynamics in dense needle liquids. The center-of-mass…

Statistical Mechanics · Physics 2008-09-22 Felix Höfling , Erwin Frey , Thomas Franosch

We have developed x-ray diffraction measurements with high energy-resolution and accuracy to study water structure at three different temperatures (7, 25 and 66 C) under normal pressure. Using a spherically curved Ge crystal an energy…

Soft Condensed Matter · Physics 2017-09-13 Congcong Huang , K. T. Wikfeldt , D. Nordlund , U. Bergmann , T. McQueen , J. Sellberg , L. G. M. Pettersson , A. Nilsson

Diffusion in an evolving environment is studied by continuos-time Monte Carlo simulations. Diffusion is modelled by continuos-time random walkers on a lattice, in a dynamic environment provided by bubbles between two one-dimensional…

Soft Condensed Matter · Physics 2010-11-22 Janne Juntunen , Juha Merikoski

The paper presents an approach for overcoming modeling problems of typical life science applications with partly unknown mechanisms and lacking quantitative data: A model family of reaction diffusion equations is built up on a mesoscopic…

Dynamical Systems · Mathematics 2023-12-12 Cordula Reisch , Sandra Nickel , Hans-Michael Tautenhahn

In diffusion-controlled drug delivery, it is possible for drug molecules to bind to the carrier material and never be released. A common way to incorporate this phenomenon into the governing mechanistic model is to include an irreversible…

Medical Physics · Physics 2024-01-19 Elliot J. Carr

Recent molecular communication (MC) research has integrated more detailed computational models to capture the dynamics of practical biophysical systems. This research focuses on developing realistic models for MC transceivers inspired by…

Microcapsules are a key class of microscale materials with applications in areas ranging from personal care to biomedicine, and with increasing potential to act as extracellular matrix (ECM) models of hollow organs or tissues. Such capsules…

We present a model for cell growth, division and packing under soft constraints that arise from the deformability of the cells as well as of a membrane that encloses them. Our treatment falls within the framework of diffuse interface…

Cell Behavior · Quantitative Biology 2019-01-09 J. Jiang , K. Garikipati , S. Rudraraju

In this series of three papers we present results from a combined experimental and theoretical effort to quantitatively describe capacitively coupled radio-frequency discharges in oxygen. The particle-in-cell Monte-Carlo model on which the…

Plasma Physics · Physics 2009-11-13 F. X. Bronold , K. Matyash , D. Tskhakaya , R. Schneider , H. Fehske

Reaction-diffusion systems have been proposed as a model for pattern formation and morphogenesis. The Fickian diffusion typically employed in these constructions model the Brownian motion of particles. The biological and chemical elements…

Quantitative Methods · Quantitative Biology 2023-11-09 Siddhartha Srivastava , Krishna Garikipati

The effects of cell size and deformability on the lateral migration and deformation of living cells flowing through a rectangular microchannel has been numerically investigated and compared with the inertial-microfluidics data on detection…

Fluid Dynamics · Physics 2013-06-21 Hongzhi Lan , Soojung Claire Hur , Dino Di Carlo , Damir B. Khismatullin

Obtaining a detailed understanding of the physical interactions between a cell and its environment often requires information about the flow of fluid surrounding the cell. Cells must be able to effectively absorb and discard material in…

Biological Physics · Physics 2017-09-04 Nathaniel J. Fuller , Nicholas A. Licata

Realistic examples of reaction-diffusion phenomena governing spatial and spatiotemporal pattern formation are rarely isolated systems, either chemically or thermodynamically. However, even formulations of `open' reaction-diffusion systems…

Pattern Formation and Solitons · Physics 2021-05-14 Andrew L. Krause , Václav Klika , Philip K. Maini , Denis Headon , Eamonn A. Gaffney

A description in terms of transition rates among cells is used to analyze self-diffusion of hard spheres in the fluid phase. Cell size is assumed much larger than the mean free path. Transition state theory is used to obtain an equation…

Statistical Mechanics · Physics 2021-11-15 Miguel Hoyuelos

A system of drift-diffusion equations for the electron, hole, and oxygene vacancy densities in a semiconductor, coupled to the Poisson equation for the electric potential, is analyzed in a bounded domain with mixed Dirichlet-Neumann…

Analysis of PDEs · Mathematics 2022-04-08 Clément Jourdana , Ansgar Jüngel , Nicola Zamponi

In this article, we propose a novel conservative diffuse-interface method for the simulation of immiscible compressible two-phase flows. The proposed method discretely conserves the mass of each phase, momentum and total energy of the…

Computational Physics · Physics 2020-06-11 Suhas S. Jain , Ali Mani , Parviz Moin

Beta cells in pancreas represent an example of coupled biological oscillators which via communication pathways, are able to synchronize their electrical activity, giving rise to pulsatile insulin release. In this work we numerically analyze…

The evolution of the interface propagation in a slowly rotating half-filled horizontal cylinder is studied using MRI. Initially, the cylinder contains two axially segregated bands of small and large particles with a sharp interface. The…

Soft Condensed Matter · Physics 2009-10-31 Gerald H. Ristow , Masami Nakagawa