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As semiconductor technologies continue to scale down to the nanoscale, the efficient prediction of material properties becomes increasingly critical. The tight-binding (TB) method is a widely used semi-empirical approach that offers a…

Materials Science · Physics 2025-11-27 In Jun Park , Kamal Choudhary

We propose to adapt the confined pseudo-atomic orbitals underpinning the precalculated Slater-Koster (SK) interaction tables in Density Functional Tight Binding (DFTB) to local atomic environments. We demonstrate significant improvement in…

Accurate prediction of drug-target binding affinity can accelerate drug discovery by prioritizing promising compounds before costly wet-lab screening. While deep learning has advanced this task, most models fuse ligand and protein…

Machine Learning · Computer Science 2025-09-26 Mohammadsaleh Refahi , Bahrad A. Sokhansanj , James R. Brown , Gail Rosen

As vast databases of chemical identities become increasingly available, the challenge shifts to how we effectively explore and leverage these resources to study molecular properties. This paper presents an active learning approach for…

Machine Learning · Computer Science 2025-07-17 Ayana Ghosh , Maxim Ziatdinov , Sergei V. Kalinin

Deep Learning (DL) algorithms hold great promise for applications in the field of computational biophysics. In fact, the vast amount of available molecular structures, as well as their notable complexity, constitutes an ideal context in…

Soft Condensed Matter · Physics 2019-01-07 Marco Giulini , Raffaello Potestio

Parameterized tight-binding models fit to first principles calculations can provide an efficient and accurate quantum mechanical method for predicting properties of molecules and solids. However, well-tested parameter sets are generally…

Materials Science · Physics 2023-04-28 Kevin F. Garrity , Kamal Choudhary

We have developed Density Functional Tight Binding (DFTB) models for cerium that accurately predict both the electronic band structure and energetic ordering of different allotropes. We show that global optimization of the electronic…

Materials Science · Physics 2026-05-06 Nir Goldman , Artem Samtsevych , Chiara Panosetti

Deep learning electronic structures from ab initio calculations holds great potential to revolutionize computational materials studies. While existing methods proved success in deep-learning density functional theory (DFT) Hamiltonian…

The predictive accuracy of density functional theory (DFT) for alloy formation enthalpies is often limited by intrinsic energy resolution errors, particularly in ternary phase stability calculations. In this work, we present a machine…

Materials Science · Physics 2025-03-10 Sergei I. Simak , Erna K. Delczeg-Czirjak , Olle Eriksson

Machine learning has emerged as a powerful tool for predicting molecular properties in chemical reaction networks with reduced computational cost. However, accurately predicting energies of transition state (TS) structures remains a…

Chemical Physics · Physics 2025-04-29 Stefan Gugler , Markus Reiher

Deep Learning has the hierarchical network architecture to represent the complicated features of input patterns. Such architecture is well known to represent higher learning capability compared with some conventional models if the best set…

Neural and Evolutionary Computing · Computer Science 2018-07-12 Takumi Ichimura , Shin Kamada

Density functional theory (DFT) is routinely employed in material science and in quantum chemistry to simulate weakly correlated electronic systems. Recently, deep learning (DL) techniques have been adopted to develop promising functionals…

Strongly Correlated Electrons · Physics 2023-10-02 Emanuele Costa , Rosario Fazio , Sebastiano Pilati

Deep neural networks have rightfully won the place of one of the most accurate analysis tools in high energy physics. In this paper we will cover several methods of improving the performance of a deep neural network in a classification task…

Data Analysis, Statistics and Probability · Physics 2021-09-20 Lev Dudko , Petr Volkov , Georgii Vorotnikov , Andrei Zaborenko

Predicting the mean-field Hamiltonian matrix in density functional theory is a fundamental formulation to leverage machine learning for solving molecular science problems. Yet, its applicability is limited by insufficient labeled data for…

Machine Learning · Computer Science 2024-06-06 He Zhang , Chang Liu , Zun Wang , Xinran Wei , Siyuan Liu , Nanning Zheng , Bin Shao , Tie-Yan Liu

The H\"uckel Hamiltonian is an incredibly simple tight-binding model famed for its ability to capture qualitative physics phenomena arising from electron interactions in molecules and materials. Part of its simplicity arises from using only…

Quantum many-body methods provide a systematic route to computing electronic properties of molecules and materials, but high computational costs restrict their use in large-scale applications. Due to the complexity in many-electron…

Density Functional Tight-Binding (DFTB), an approximative approach derived from Density Functional Theory (DFT), has the potential to pave the way for simulations of large periodic or non-periodic systems. We have specifically tailored DFTB…

Machine Learning (ML) techniques have been employed for the high energy physics (HEP) community since the early 80s to deal with a broad spectrum of problems. This work explores the prospects of using Deep Learning techniques to estimate…

High Energy Physics - Phenomenology · Physics 2022-06-22 Neelkamal Mallick , Suraj Prasad , Aditya Nath Mishra , Raghunath Sahoo , Gergely Gábor Barnaföldi

Comparative molecular dynamics simulations of a hexamer cluster of the protic ionic liquid ethylammonium nitrate are performed using density functional theory (DFT) and density functional-based tight binding (DFTB) methods. The focus is on…

Chemical Physics · Physics 2017-03-24 Tobias Zentel , Oliver Kühn

Deep learning methods have shown great promise in many practical applications, ranging from speech recognition, visual object recognition, to text processing. However, most of the current deep learning methods suffer from scalability…

Machine Learning · Statistics 2015-08-31 Yanping Huang , Sai Zhang