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In this work we study reverse complementary genomic word pairs in the human DNA, by comparing both the distance distribution and the frequency of a word to those of its reverse complement. Several measures of dissimilarity between distance…

In this work we explore the dissimilarity between symmetric word pairs, by comparing the inter-word distance distribution of a word to that of its reversed complement. We propose a new measure of dissimilarity between such distributions.…

We describe and experimentally evaluate a method for automatically clustering words according to their distribution in particular syntactic contexts. Deterministic annealing is used to find lowest distortion sets of clusters. As the…

cmp-lg · Computer Science 2008-02-03 Fernando Pereira , Naftali Tishby , Lillian Lee

This paper presents a novel method to segment/decode DNA sequences based on n-grams statistical language model. Firstly, we find the length of most DNA 'words' is 12 to 15 bps by analyzing the genomes of 12 model species. Then we design an…

Genomics · Quantitative Biology 2015-03-13 Wang Liang

Analyses of targeted genomic sequencing data from next-generation-sequencing (NGS) technologies typically involves mapping reads to a reference sequence or clustering reads. For a number of species a reference genome is not available so the…

Genomics · Quantitative Biology 2016-02-16 Raunaq Malhotra , Daniel Elleder , Le Bao , David R Hunter , Raj Acharya , Mary Poss

Considering that words with different characteristic in the text have different importance for classification, grouping them together separately can strengthen the semantic expression of each part. Thus we propose a new text representation…

Computation and Language · Computer Science 2019-06-19 Xiaoye Tan , Rui Yan , Chongyang Tao , Mingrui Wu

Clustering of gene expression time series gives insight into which genes may be coregulated, allowing us to discern the activity of pathways in a given microarray experiment. Of particular interest is how a given group of genes varies with…

Quantitative Methods · Quantitative Biology 2018-02-13 Muhammad Arifur Rahman , Paul R. Heath , Neil D. Lawrence

We present a technique for clustering categorical data by generating many dissimilarity matrices and averaging over them. We begin by demonstrating our technique on low dimensional categorical data and comparing it to several other…

Machine Learning · Statistics 2017-09-20 Saeid Amiri , Bertrand Clarke , Jennifer Clarke

We address the problem of clustering words (or constructing a thesaurus) based on co-occurrence data, and using the acquired word classes to improve the accuracy of syntactic disambiguation. We view this problem as that of estimating a…

cmp-lg · Computer Science 2007-05-23 Hang Li , Naoki Abe

We propose a new approach for clustering DNA features using array CGH data from multiple tumor samples. We distinguish data-collapsing: joining contiguous DNA clones or probes with extremely similar data into regions, from clustering:…

Applications · Statistics 2010-12-21 Kyung In Kim , Etienne Roquain , Mark Van De Wiel

A probabilistic clustering algorithm is proposed for the analysis of forensic DNA mixtures in which individual cells are isolated and short tandem repeats are amplified using the polymerase chain reaction to generate single cell…

Applications · Statistics 2025-10-14 Robert G. Cowell

The huge amount of data acquired by high-throughput sequencing requires data reduction for effective analysis. Here we give a clustering algorithm for genome-wide open chromatin data using a new data reduction method. This method regards…

Genomics · Quantitative Biology 2024-10-14 Azusa Tanaka , Yasuhiro Ishitsuka , Hiroki Ohta , Akihiro Fujimoto , Jun-ichirou Yasunaga , Masao Matsuoka

Cluster analysis of biological samples using gene expression measurements is a common task which aids the discovery of heterogeneous biological sub-populations having distinct mRNA profiles. Several model-based clustering algorithms have…

Methodology · Statistics 2012-01-30 Alberto Cozzini , Ajay Jasra , Giovanni Montana

This paper (cmp-lg/yymmnnn) has been accepted for publication in the student session of EACL-95. It outlines ongoing work using statistical and unsupervised neural network methods for clustering words in untagged corpora. Such approaches…

cmp-lg · Computer Science 2008-02-03 Christopher C. Huckle

Genome wide comparisons between enteric bacteria yield large sets of conserved putative regulatory sites on a gene by gene basis that need to be clustered into regulons. Using the assumption that regulatory sites can be represented as…

Biological Physics · Physics 2009-11-07 Erik van Nimwegen , Mihaela Zavolan , Nikolaus Rajewsky , Eric D. Siggia

As a kind of basic machine learning method, clustering algorithms group data points into different categories based on their similarity or distribution. We present a clustering algorithm by finding hyper-planes to distinguish the data…

Computer Vision and Pattern Recognition · Computer Science 2020-04-28 Luhong Diao , Jinying Gao1 , Manman Deng

This study focuses on an alignment-free sequence comparison method: the number of words of length k shared between two sequences, also known as the D_2 statistic. The advantages of the use of this statistic over alignment-based methods are…

Quantitative Methods · Quantitative Biology 2009-09-08 Sylvain Foret , Susan R. Wilson , Conrad J. Burden

Clustering a lexicon of words is a well-studied problem in natural language processing (NLP). Word clusters are used to deal with sparse data in statistical language processing, as well as features for solving various NLP tasks (text…

Computation and Language · Computer Science 2018-08-17 Effi Levi , Saggy Herman , Ari Rappoport

Distributional text clustering delivers semantically informative representations and captures the relevance between each word and semantic clustering centroids. We extend the neural text clustering approach to text classification tasks by…

Computation and Language · Computer Science 2020-11-25 Yekun Chai , Haidong Zhang , Shuo Jin

Any approach aimed at pasteurizing and quantifying a particular phenomenon must include the use of robust statistical methodologies for data analysis. With this in mind, the purpose of this study is to present statistical approaches that…

Computation and Language · Computer Science 2023-06-29 Anagh Chattopadhyay , Soumya Sankar Ghosh , Samir Karmakar
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