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The correct use and interpretation of models depends on several steps, two of which being the calibration by parameter estimation and the analysis of uncertainty. In the biological literature, these steps are seldom discussed together, but…

Quantitative Methods · Quantitative Biology 2015-08-17 André Chalom , Paulo Inácio de Knegt López de Prado

In many real-world applications of machine learning such as recommendations, hiring, and lending, deployed models influence the data they are trained on, leading to feedback loops between predictions and data distribution. The performative…

Machine Learning · Computer Science 2025-11-18 Kun Jin , Tian Xie , Yang Liu , Xueru Zhang

Causality is a central concept in a wide range of research areas, yet there is still no universally agreed axiomatisation of causality. We view causality both as an extension of probability theory and as a study of \textit{what happens when…

Artificial Intelligence · Computer Science 2024-06-07 Junhyung Park , Simon Buchholz , Bernhard Schölkopf , Krikamol Muandet

We present Causal Posterior Estimation (CPE), a novel method for Bayesian inference in simulator models, i.e., models where the evaluation of the likelihood function is intractable or too computationally expensive, but where one can…

Machine Learning · Computer Science 2025-05-28 Simon Dirmeier , Antonietta Mira

Compartmental epidemic models have been widely used for predicting the course of epidemics, from estimating the basic reproduction number to guiding intervention policies. Studies commonly acknowledge these models' assumptions but less…

Populations and Evolution · Quantitative Biology 2022-11-23 Alexander F. Siegenfeld , Pratyush K. Kollepara , Yaneer Bar-Yam

The standard approach to answering an identifiable causal-effect query (e.g., $P(Y|do(X)$) when given a causal diagram and observational data is to first generate an estimand, or probabilistic expression over the observable variables, which…

Artificial Intelligence · Computer Science 2024-08-28 Anna Raichev , Alexander Ihler , Jin Tian , Rina Dechter

Advancements in computational power and methodologies have enabled research on massive datasets. However, tools for analyzing data with directional or periodic characteristics, such as wind directions and customers' arrival time in 24-hour…

Methodology · Statistics 2026-04-07 Xiang Ye , Janet Van Niekerk , Håvard Rue

Causal discovery problems use a set of observations to deduce causality between variables in the real world, typically to answer questions about biological or physical systems. These observations are often recorded at regular time…

Signal Processing · Electrical Eng. & Systems 2026-02-24 Kurt Butler , Damian Machlanski , Panagiotis Dimitrakopoulos , Sotirios A. Tsaftaris

We introduce an approach to inferring the causal architecture of stochastic dynamical systems that extends rate distortion theory to use causal shielding---a natural principle of learning. We study two distinct cases of causal inference:…

Information Theory · Computer Science 2010-08-23 Susanne Still , James P. Crutchfield , Christopher J. Ellison

Many statistical problems in causal inference involve a probability distribution other than the one from which data are actually observed; as an additional complication, the object of interest is often a marginal quantity of this other…

Methodology · Statistics 2023-10-24 Robin J. Evans , Vanessa Didelez

Causal machine learning has the potential to revolutionize decision-making by combining the predictive power of machine learning algorithms with the theory of causal inference. However, these methods remain underutilized by the broader…

How should social scientists understand and communicate the uncertainty of statistically estimated causal effects? I propose we utilize the posterior distribution of a causal effect and present the probability of the effect being greater…

Applications · Statistics 2022-11-15 Akisato Suzuki

Identifying the effects of causes and causes of effects is vital in virtually every scientific field. Often, however, the needed probabilities may not be fully identifiable from the data sources available. This paper shows how partial…

Artificial Intelligence · Computer Science 2023-01-31 Ang Li , Scott Mueller , Judea Pearl

Causality testing, the act of determining cause and effect from measurements, is widely used in physics, climatology, neuroscience, econometrics and other disciplines. As a result, a large number of causality testing methods based on…

Data Analysis, Statistics and Probability · Physics 2018-02-20 Aditi Kathpalia , Nithin Nagaraj

Machine Learning explainability techniques have been proposed as a means of `explaining' or interrogating a model in order to understand why a particular decision or prediction has been made. Such an ability is especially important at a…

Machine Learning · Statistics 2022-02-28 Matthew J. Vowels

When we work with information from multiple sources, the formalism each employs to handle uncertainty may not be uniform. In order to be able to combine these knowledge bases of different formats, we need to first establish a common basis…

Artificial Intelligence · Computer Science 2013-02-18 Choh Man Teng

We present a symbolic machinery that admits both probabilistic and causal information about a given domain and produces probabilistic statements about the effect of actions and the impact of observations. The calculus admits two types of…

Artificial Intelligence · Computer Science 2013-02-28 Judea Pearl

The aim of this paper is to present an elementary computable theory of random variables, based on the approach to probability via valuations. The theory is based on a type of lower-measurable sets, which are controlled limits of open sets,…

Logic in Computer Science · Computer Science 2021-01-05 Pieter Collins

Bayesian inference and the use of posterior or posterior predictive probabilities for decision making have become increasingly popular in clinical trials. The current practice in Bayesian clinical trials relies on a hybrid…

Methodology · Statistics 2024-04-30 Shirin Golchi , James Willard

Whether a variable is the cause of another, or simply associated with it, is often an important scientific question. Causal Inference is the name associated with the body of techniques for addressing that question in a statistical setting.…

Applications · Statistics 2025-06-25 Caren Marzban , Yikun Zhang , Nicholas Bond , Michael Richman