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Dementia diagnosis requires a series of different testing methods, which is complex and time-consuming. Early detection of dementia is crucial as it can prevent further deterioration of the condition. This paper utilizes a speech…

Computation and Language · Computer Science 2023-12-18 Zih-Jyun Lin , Yi-Ju Chen , Po-Chih Kuo , Likai Huang , Chaur-Jong Hu , Cheng-Yu Chen

We explore a lightweight framework that adapts frozen large language models to analyze longitudinal clinical data. The approach integrates patient history and context within the language model space to generate accurate forecasts without…

Computation and Language · Computer Science 2025-10-29 Tananun Songdechakraiwut , Michael Lutz

Dementia, a progressive neurodegenerative disorder, affects memory, reasoning, and daily functioning, creating challenges for individuals and healthcare systems. Early detection is crucial for timely interventions that may slow disease…

Neurons and Cognition · Quantitative Biology 2025-03-04 Sahar Sinene Mehdoui , Abdelhamid Bouzid , Daniel Sierra-Sosa , Adel Elmaghraby

Ensemble learning use multiple algorithms to obtain better predictive performance than any single one of its constituent algorithms could. With growing popularity of deep learning, researchers have started to ensemble them for various…

Machine Learning · Computer Science 2019-05-31 Ning An , Huitong Ding , Jiaoyun Yang , Rhoda Au , Ting Fang Alvin Ang

As other neurodegenerative diseases, Alzheimer's disease, the most frequent dementia in the elderly, is characterized by multiple progressive impairments in the brain structure and in clinical functions such as cognitive functioning and…

Methodology · Statistics 2019-10-21 Cécile Proust-Lima , Viviane Philipps , Jean-François Dartigues

Dementia, a prevalent neurodegenerative condition, is a major manifestation of Alzheimer's disease (AD). As the condition progresses from mild to severe, it significantly impairs the individual's ability to perform daily tasks…

Machine Learning · Computer Science 2023-11-06 Md Gulzar Hussain , Ye Shiren

The aim of this paper is to investigate the benefit of combining both language and acoustic modelling for speaker diarization. Although conventional systems only use acoustic features, in some scenarios linguistic data contain high…

Audio and Speech Processing · Electrical Eng. & Systems 2025-01-31 Miquel India , Javier Hernando , José A. R. Fonollosa

Data harmonization is the process by which an equivalence is developed between two variables measuring a common trait. Our problem is motivated by dementia research in which multiple tests are used in practice to measure the same underlying…

Methodology · Statistics 2021-10-13 Steven Wilkins-Reeves , Yen-Chi Chen , Kwun Chuen Gary Chan

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to irreversible cognitive decline in memory and communication. Early detection of AD through speech analysis is crucial for delaying disease progression.…

Sound · Computer Science 2026-02-09 Yifan Gao , Long Guo , Hong Liu

Early diagnosis of Alzheimer's disease and related dementias (ADRD) is critical for timely intervention, yet most diagnoses are delayed until advanced stages. While comprehensive patient narratives are essential for accurate diagnosis,…

Human-Computer Interaction · Computer Science 2026-01-28 Andrew G. Breithaupt , Nayoung Choi , James D. Finch , Jeanne M. Powell , Arin L. Nelson , Oz A. Alon , Howard J. Rosen , Jinho D. Choi

Data limitation is one of the most common issues in training machine learning classifiers for medical applications. Due to ethical concerns and data privacy, the number of people that can be recruited to such experiments is generally…

Audio and Speech Processing · Electrical Eng. & Systems 2020-04-14 Bahman Mirheidari , Yilin Pan , Daniel Blackburn , Ronan O'Malley , Traci Walker , Annalena Venneri , Markus Reuber , Heidi Christensen

Building trustworthy clinical AI systems requires not only accurate predictions but also transparent, biologically grounded explanations. We present \texttt{DiagnoLLM}, a hybrid framework that integrates Bayesian deconvolution, eQTL-guided…

Artificial Intelligence · Computer Science 2025-11-18 Bowen Xu , Xinyue Zeng , Jiazhen Hu , Tuo Wang , Adithya Kulkarni

Alzheimer's dementia (AD) affects memory, thinking, and language, deteriorating person's life. An early diagnosis is very important as it enables the person to receive medical help and ensure quality of life. Therefore, leveraging…

Machine Learning · Computer Science 2023-04-06 Michail Chatzianastasis , Loukas Ilias , Dimitris Askounis , Michalis Vazirgiannis

Alzheimer's Disease (AD) is a prevalent neurodegenerative condition where early detection is vital. Handwriting, often affected early in AD, offers a non-invasive and cost-effective way to capture subtle motor changes. State-of-the-art…

Computer Vision and Pattern Recognition · Computer Science 2024-10-15 Changqing Gong , Huafeng Qin , Mounîm A. El-Yacoubi

We replicate a variation of the image captioning architecture by Vinyals et al. (2015), then introduce dropout during inference mode to simulate the effects of neurodegenerative diseases like Alzheimer's disease (AD) and Wernicke's aphasia…

Computation and Language · Computer Science 2018-08-14 Bai Li , Ran Zhang , Frank Rudzicz

Early diagnosis of Alzheimer's Disease (AD) is crucial for delaying its progression. While AI-based speech detection is non-invasive and cost-effective, it faces a critical data efficiency dilemma due to medical data scarcity and privacy…

Computation and Language · Computer Science 2026-02-17 Xiao Wei , Bin Wen , Yuqin Lin , Kai Li , Mingyang gu , Xiaobao Wang , Longbiao Wang , Jianwu Dang

Traditionally, Latent Dirichlet Allocation (LDA) ingests words in a collection of documents to discover their latent topics using word-document co-occurrences. However, it is unclear how to achieve the best results for languages without…

Computation and Language · Computer Science 2021-08-25 Jin Cheevaprawatdomrong , Alexandra Schofield , Attapol T. Rutherford

Generative AI framework-based modeling and prediction of longitudinal human brain images offer an efficient mechanism to track neurodegenerative progression, essential for the assessment of diseases like Alzheimer's. Among the existing…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Ayantika Das , Keerthi Ram , Mohanasankar Sivaprakasam

We introduce incremental variational inference and apply it to latent Dirichlet allocation (LDA). Incremental variational inference is inspired by incremental EM and provides an alternative to stochastic variational inference. Incremental…

Machine Learning · Statistics 2015-07-23 Cedric Archambeau , Beyza Ermis

Conventional word embeddings represent words with fixed vectors, which are usually trained based on co-occurrence patterns among words. In doing so, however, the power of such representations is limited, where the same word might be…

Computation and Language · Computer Science 2020-01-10 Hongming Zhang , Jiaxin Bai , Yan Song , Kun Xu , Changlong Yu , Yangqiu Song , Wilfred Ng , Dong Yu
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