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We present a high-throughput microfluidic platform capable of quantitating up to 384 biomarkers in 4 distinct samples by immunoassay. The microfluidic device contains 384 unit cells, which can be individually programmed with pairs of…

Quantitative Methods · Quantitative Biology 2015-06-23 Francesca Volpetti , Jose Garcia-Cordero , Sebastian Maerkl

This work presents a new multi-chemical experimental platform for molecular communication where the transmitter can release different chemicals. This platform is designed to be inexpensive and accessible, and it can be expanded to simulate…

Emerging Technologies · Computer Science 2017-04-18 Nariman Farsad , David Pan , Andrea Goldsmith

Microwave sensors can probe intrinsic material properties of analytes in a microfluidic channel at physiologically relevant ion concentrations. While microwave sensors have been used to detect single cells and microparticles in earlier…

High-Q optical resonators allow label-free detection of individual nanoparticles through perturbation of optical signatures but have practical limitations due to reliance on random diffusion to deliver particles to the sensing region. We…

Optics · Physics 2016-10-03 Jeewon Suh , Kewen Han , Christopher W Peterson , Gaurav Bahl

This paper describes continuously phase-modulated standing surface acoustic waves (CPM-SSAW) and its application for particle separation in multiple pressure nodes. A linear change of phase in CPM-SSAW applies a force to particles whose…

Fluid Dynamics · Physics 2017-04-05 Junseok Lee , Chanryeol Rhyou , Byungjun Kang , Hyungsuk Lee

We report on a microfluidic method that allows measurement of a small concentration of large contaminants in suspensions of solid micrometer-scale particles. To perform the measurement, we flow the colloidal suspension through a series of…

In the work, the new method for the design of the wavelength division multiplexer on the basis of 2D photonic crystal integrated circuit for the ultra-short pulses channel separation is proposed and investigated. The method is based on the…

The development of mode-division multiplexing techniques is an important step to increase the information processing capacity. In this context, we design an efficient and robust mode-division (de)multiplexing integrated device based on the…

Optics · Physics 2018-06-04 G. Queraltó , V. Ahufinger , J. Mompart

Label-free detecting multiple analytes in a high-throughput fashion has been one of the long-sought goals in biosensing applications. Yet, for all-optical approaches, interfacing state-of-the-art label-free techniques with microfluidics…

Quantitative Methods · Quantitative Biology 2023-08-14 Alexia Stollmann , Jose Garcia-Guirado , Jae-Sang Hong , Hyungsoon Im , Hakho Lee , Jaime Ortega Arroyo , Romain Quidant

Flow-based microfluidic biochips are widely used in lab- on-a-chip experiments. In these chips, devices such as mixers and detectors connected by micro-channels execute specific operations. Intermediate fluid samples are saved in storage…

Emerging Technologies · Computer Science 2017-05-16 Tsun-Ming Tseng , Bing Li , Tsung-Yi Ho , Ulf Schlichtmann

Adsorption processes play a fundamental role in molecular transport through nanofluidic systems, but their signatures in measured signals are often hard to distinguish from other processes like diffusion. In this paper, we derive an…

Soft Condensed Matter · Physics 2025-11-07 Anna Drummond Young , Alice L. Thorneywork , Sophie Marbach

Precise manipulation of fluids and objects on the micro scale is seldom a simple task, but nevertheless crucial for many applications in life sciences and chemical engineering. We present a microfluidic chip fabricated in silicon-glass,…

Droplet-based microfluidic systems are a promising platform forlab-on-a-chip (LoC) applications. These systems can also be used toenhance LoC applications with integrated droplet control information or for data transmission scenarios in the…

Emerging Technologies · Computer Science 2021-01-12 Max Bartunik , Marco Fleischer , Werner Haselmayr , Jens Kirchner

Separation is a crucial step in the analysis of living microparticles. In particular, the selective microseparation of phytoplankton by size and shape remains an open problem, even though these criteria are essential for their gender and/or…

Applied Physics · Physics 2025-04-09 Nicolas Ruyssen , Bastien Oliva , Lylian Challier , Vincent Noël , Benjamin Rotenberg

The encapsulation and co-encapsulation of particles in microfluidic flows is essential in applications related to single-cell analysis and material synthesis. However, the whole encapsulation process is stochastic in nature, and its…

Fluid Dynamics · Physics 2022-06-20 Keshvad Shahrivar , Francesco Del Giudice

Dielectrophoresis is an electric field-based technique for moving neutral particles through a fluid. When used for particle separation, dielectrophoresis has many advantages compared to other methods, providing label-free operation with…

We demonstrate a hybrid distributed fiber sensing system for multi-parameter detection. The integration of phase-sensitive optical time domain reflectometry ({\Phi}-OTDR) and Brillouin optical time domain reflectometry (B-OTDR) enables…

Optics · Physics 2016-09-02 Jingdong Zhang , Tao Zhu , Huan Zhou , Yang Li , Min Liu , Wei Huang

Objective: We aim to improve operational robustness of liquid scanning probes. Two main failure modes to be addressed are an obstruction of the flow path of the processing liquid and a deviation from the desired gap distance between probe…

Applied Physics · Physics 2019-01-03 David P. Taylor , Govind V. Kaigala

This article introduces a novel communication scheme, termed coded compressed sensing, for unsourced multiple-access communication. The proposed divide-and-conquer approach leverages recent advances in compressed sensing and forward error…

Signal Processing · Electrical Eng. & Systems 2019-06-26 Vamsi K. Amalladinne , Jean-Francois Chamberland , Krishna R. Narayanan

This paper proposes a novel multifunctional sensing platform based on multimode planar photonic crystals (PPCs). We analytically and numerically demonstrate that the reflection spectrum of PPCs exhibits multiple high-Q resonant modes, and…

Optics · Physics 2017-01-13 Yongyao Chen , Haijun Liu , Zhijian Zhang , Miao Yu