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Despite decades of clinical research, sepsis remains a global public health crisis with high mortality, and morbidity. Currently, when sepsis is detected and the underlying pathogen is identified, organ damage may have already progressed to…

It is evident that increasing the intensive-care-unit (ICU) capacity and giving priority to admitting and treating younger patients will reduce the number of COVID-19 deaths, but a quantitative assessment of these measures has remained…

Physics and Society · Physics 2020-12-29 Ying-Qi Zeng , Lang Zeng , Ming Tang , Ying Liu , Zong-Hua Liu , Ying-Cheng Lai

Measuring the effect of patient safety improvement efforts is needed to determine their value but is difficult due to the inherent complexities of hospital operations. In this paper, we show by case study how interrupted time series design…

Applications · Statistics 2018-06-28 Diego A. Martinez , Mehdi Jalalpour , David T. Efron , Scott R. Levin

Objective: Sepsis is a life-threatening condition. Sequential Organ Failure Assessment (SOFA) score is commonly used to assess organ dysfunction and predict ICU mortality, but it is taken as a static measurement and fails to capture dynamic…

Quantitative Methods · Quantitative Biology 2023-11-30 Yuhe Ke , Matilda Swee Sun Tang , Celestine Jia Ling Loh , Hairil Rizal Abdullah , Nicholas Brian Shannon

The pressure of ever-increasing patient demand and budget restrictions make hospital bed management a daily challenge for clinical staff. Most critical is the efficient allocation of resource-heavy Intensive Care Unit (ICU) beds to the…

Machine Learning · Computer Science 2021-02-25 Emma Rocheteau , Pietro Liò , Stephanie Hyland

Background: Trends in hospitalised case-fatality risk (HFR), risk of intensive care unit (ICU) admission and lengths of stay for patients hospitalised for COVID-19 in England over the pre-vaccination era are unknown. Methods: Data on…

Early prediction of in-hospital mortality in critically ill patients can aid clinicians in optimizing treatment. The objective was to develop a multimodal deep learning model, using structured and unstructured clinical data, to predict…

Machine Learning · Computer Science 2025-12-24 Behrooz Mamandipoor , Chun-Nan Hsu , Martin Krause , Ulrich H. Schmidt , Rodney A. Gabriel

Sepsis is one of the leading causes of death in Intensive Care Units (ICU). The strategy for treating sepsis involves the infusion of intravenous (IV) fluids and administration of antibiotics. Determining the optimal quantity of IV fluids…

Artificial Intelligence · Computer Science 2020-09-18 Akash Gupta , Michael T. Lash , Senthil K. Nachimuthu

The intensive care unit (ICU) comprises a complex hospital environment, where decisions made by clinicians have a high level of risk for the patients' lives. A comprehensive care pathway must then be followed to reduce p complications.…

Intensive care occupancy is an important indicator of health care stress that has been used to guide policy decisions during the COVID-19 pandemic. Toward reliable decision-making as a pandemic progresses, estimating the rates at which…

Methodology · Statistics 2023-07-18 Achal Awasthi , Volodymyr M. Minin , Jenny Huang , Daniel Chow , Jason Xu

This paper focuses on drawing information on underlying processes, which are not directly observed in the data. In particular, we work with data in which only the total count of units in a system at a given time point is observed, but the…

Applications · Statistics 2026-01-22 Martje Rave , Göran Kauermann

Sepsis accounts for more than 50% of hospital deaths, and the associated cost ranks the highest among hospital admissions in the US. Improved understanding of disease states, severity, and clinical markers has the potential to significantly…

Quantitative Methods · Quantitative Biology 2022-10-11 Chih-Hao Fang , Vikram Ravindra , Salma Akhter , Mohammad Adibuzzaman , Paul Griffin , Shankar Subramaniam , Ananth Grama

Sepsis is a leading cause of mortality in intensive care units (ICUs) and costs hospitals billions annually. Treating a septic patient is highly challenging, because individual patients respond very differently to medical interventions and…

Machine Learning · Computer Science 2017-05-24 Aniruddh Raghu , Matthieu Komorowski , Leo Anthony Celi , Peter Szolovits , Marzyeh Ghassemi

Understanding how effective high-level NICUs (neonatal intensive care units that have the capacity for sustained mechanical assisted ventilation and high volume) are compared to low-level NICUs is important and valuable for both individual…

Applications · Statistics 2014-04-10 Fan Yang , Scott A. Lorch , Dylan S. Small

ICU readmission is associated with longer hospitalization, mortality and adverse outcomes. An early recognition of ICU re-admission can help prevent patients from worse situation and lower treatment cost. As the abundance of Electronics…

Machine Learning · Computer Science 2019-10-08 Zhiheng Li , Xinyue Xing , Bingzhang Lu , Zhixiang Li

Background: The predictive Intensive Care Unit (ICU) scoring system plays an important role in ICU management because it predicts important outcomes, especially mortality. Many scoring systems have been developed and used in the ICU. These…

Artificial Intelligence · Computer Science 2023-07-18 Mingquan Lin , Song Wang , Ying Ding , Lihui Zhao , Fei Wang , Yifan Peng

Intracerebral hemorrhage (ICH) is a life-risking condition characterized by bleeding within the brain parenchyma. ICU readmission in ICH patients is a critical outcome, reflecting both clinical severity and resource utilization. Accurate…

Machine Learning · Computer Science 2025-01-03 Shuheng Chen , Junyi Fan , Armin Abdollahi , Negin Ashrafi , Kamiar Alaei , Greg Placencia , Maryam Pishgar

Purpose: To explore the issue of counterintuitive data via analysis of a representative case and further discussion of those situations in which the data appear to be inconsistent with current knowledge. Case: 844 postoperative CABG…

Other Quantitative Biology · Quantitative Biology 2018-06-15 E. Doty , N. McCague , D. J. Stone , L. A. Celi

Time series data are prevalent in electronic health records, mostly in the form of physiological parameters such as vital signs and lab tests. The patterns of these values may be significant indicators of patients' clinical states and there…

Machine Learning · Computer Science 2019-11-18 Kun Zhang , Yuan Xue , Gerardo Flores , Alvin Rajkomar , Claire Cui , Andrew M. Dai

We used survival analysis to quantify the impact of postdischarge evaluation and management (E/M) services in preventing hospital readmission or death. Our approach avoids a specific pitfall of applying machine learning to this problem,…