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A molecular understanding of how protein function is related to protein structure will require an ability to understand large conformational changes between multiple states. Unfortunately these states are often separated by high free energy…

Biological Physics · Physics 2011-08-08 Juan R. Perilla , Thomas B. Woolf

We provide new results showing identification of a large class of fixed-T panel models, where the response variable is an unknown, weakly monotone, time-varying transformation of a latent linear index of fixed effects, regressors, and an…

Econometrics · Economics 2021-04-07 Irene Botosaru , Chris Muris , Krishna Pendakur

We explore the relationship among model fidelity, experimental design, and parameter estimation in sloppy models. We show that the approximate nature of mathematical models poses challenges for experimental design in sloppy models. In many…

Quantitative Methods · Quantitative Biology 2017-02-08 Andrew White , Malachi Tolman , Howard D. Thames , Hubert Rodney Withers , Kathy A. Mason , Mark K. Transtrum

We develop a mathematical model of extinction and coexistence in a generic predator-prey ecosystem composed of two herbivores in asymmetrical competition and a hunter exerting a predatory pressure on both species. With the aim of…

Adaptation and Self-Organizing Systems · Physics 2017-08-28 Marcelo N Kuperman , Fabiana Laguna , Guillermo Abramson , Adrian Monjeau. Jose Luis Lanata

Traditional Collaborative Filtering (CF) based methods are applied to understand the personal preferences of users/customers for items or products from the rating matrix. Usually, the rating matrix is sparse in nature. So there are some…

Information Retrieval · Computer Science 2022-10-12 Supriyo Mandal , Abyayananda Maiti

This is the second of two papers dedicated to the relationship between population models of competition and biodiversity. Here we consider species assembly models where the population dynamics is kept far from fixed points through the…

Populations and Evolution · Quantitative Biology 2007-05-23 Ugo Bastolla , Michael Lässig , Susanna C. Manrubia , Angelo Valleriani

A widely adopted approach to solving constraint satisfaction problems combines systematic tree search with various degrees of constraint propagation for pruning the search space. One common technique to improve the execution efficiency is…

Logic in Computer Science · Computer Science 2007-05-23 Chiu Wo Choi , Jimmy Ho-Man Lee , Peter J. Stuckey

Food-web perturbations stemming from climate change, overexploitation, invasive species, and habitat degradation often cause an initial loss of species that results in a cascade of secondary extinctions, posing considerable challenges to…

Populations and Evolution · Quantitative Biology 2011-03-10 Sagar Sahasrabudhe , Adilson E. Motter

Redundancy matrices provide insights into the load carrying behavior of statically indeterminate structures. This information can be employed for the design and analysis of structures with regard to certain objectives, for example…

Computational Engineering, Finance, and Science · Computer Science 2023-06-22 Tim Krake , Malte von Scheven , Jan Gade , Moataz Abdelaal , Daniel Weiskopf , Manfred Bischoff

Spatially dependent parameters of a two-component chaotic reaction-diffusion PDE model describing ocean ecology are observed by sampling a single species. We estimate model parameters and the other species in the system by…

Dynamical Systems · Mathematics 2017-04-05 Sean Kramer , Erik M. Bollt

The development of mechanistic models of biological systems is a central part of Systems Biology. One major task in developing these models is the inference of the correct model parameters. Due to the size of most realistic models and their…

Quantitative Methods · Quantitative Biology 2016-06-28 Jan Mikelson , Mustafa Khammash

We introduce two models of non-parametric random utility for demand systems: the stochastic absolute risk aversion (SARA) model, and the stochastic safety-first (SSF) model. In each model, individual-level heterogeneity is characterized by…

Econometrics · Economics 2021-01-05 Christopher Dobronyi , Christian Gouriéroux

The Rasch model is the most prominent member of the class of latent trait models that are in common use. The main reason is that it can be considered as a measurement model that allows to separate person and item parameters, a feature that…

Methodology · Statistics 2023-01-10 Gerhard Tutz

This paper addresses the problem of adding redundancy to a collection of physical objects so that the overall system is more robust to failures. In contrast to its information counterpart, which can exploit parity to protect multiple…

Information Theory · Computer Science 2017-11-09 Jennifer Tang , Da Wang , Yury Polyanskiy , Gregory Wornell

Resilience has emerged as a crucial concept for evaluating structural performance under disasters because of its ability to extend beyond traditional risk assessments, accounting for a system's ability to minimize disruptions and maintain…

Applications · Statistics 2024-04-23 Taeyong Kim , Sang-ri Yi

Access to a large variety of data across a massive population has made it possible to predict customer purchase patterns and responses to marketing campaigns. In particular, accurate demand forecasts for popular products with frequent…

Machine Learning · Statistics 2019-01-01 Tianle Chen , Brian Keng , Javier Moreno

Demands on the disaster response capacity of the European Union are likely to increase, as the impacts of disasters continue to grow both in size and frequency. This has resulted in intensive research on issues concerning spatially-explicit…

Computational Engineering, Finance, and Science · Computer Science 2014-09-30 Dario Rodriguez-Aseretto , Christian Schaerer , Daniele de Rigo

For data segmentation in high-dimensional linear regression settings, the regression parameters are often assumed to be sparse segment-wise, which enables many existing methods to estimate the parameters locally via $\ell_1$-regularised…

Methodology · Statistics 2026-05-08 Haeran Cho , Tobias Kley , Housen Li

A variety of works in the literature strive to uncover the factors associated with survival behaviour. However, the computational tools to provide such information are global models designed to predict if or when a (survival) event will…

Machine Learning · Computer Science 2021-09-07 Juliana Barcellos Mattos , Paulo S. G. de Mattos Neto , Renato Vimieiro

Food webs represent the set of consumer-resource interactions among a set of species that co-occur in a habitat, but most food web studies have omitted parasites and their interactions. Recent studies have provided conflicting evidence on…

Populations and Evolution · Quantitative Biology 2015-05-19 Abigail Z. Jacobs , Jennifer A. Dunne , Cristopher Moore , Aaron Clauset