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We propose a multiresolution Gaussian process to capture long-range, non-Markovian dependencies while allowing for abrupt changes. The multiresolution GP hierarchically couples a collection of smooth GPs, each defined over an element of a…

Methodology · Statistics 2012-09-06 Emily B. Fox , David B. Dunson

To determine the optimal set of hyperparameters of a Gaussian process based on a large number of training data, both a linear system and a trace estimation problem must be solved. In this paper, we focus on establishing numerical methods…

Optimization and Control · Mathematics 2023-12-27 Josie König , Max Pfeffer , Martin Stoll

This paper presents a Bayesian regression model relating scalar outcomes to brain functional connectivity represented as symmetric positive definite (SPD) matrices. Unlike many proposals that simply vectorize the matrix-valued connectivity…

Methodology · Statistics 2024-03-28 Xiaomeng Ju , Hyung G. Park , Thaddeus Tarpey

Discovering genes with similar functions across diverse biomedical contexts poses a significant challenge in gene representation learning due to data heterogeneity. In this study, we resolve this problem by introducing a novel model called…

Machine Learning · Computer Science 2023-10-05 Tianyu Liu , Yuge Wang , Rex Ying , Hongyu Zhao

Multi-task/Multi-output learning seeks to exploit correlation among tasks to enhance performance over learning or solving each task independently. In this paper, we investigate this problem in the context of Gaussian Processes (GPs) and…

Machine Learning · Statistics 2018-05-10 Weitong Ruan , Eric L. Miller

Magnetic Resonance Imaging (MRI) is a principal diagnostic approach used in the field of radiology to create images of the anatomical and physiological structure of patients. MRI is the prevalent medical imaging practice to find…

Computer Vision and Pattern Recognition · Computer Science 2021-06-16 Yusuf Brima , Mossadek Hossain Kamal Tushar , Upama Kabir , Tariqul Islam

Combined inference for heterogeneous high-dimensional data is critical in modern biology, where clinical and various kinds of molecular data may be available from a single study. Classical genetic association studies regress a single…

Applications · Statistics 2017-03-22 Hélène Ruffieux , Anthony C. Davison , Jörg Hager , Irina Irincheeva

Segmentation of structural and diffusion MRI (sMRI/dMRI) is usually performed independently in neuroimaging pipelines. However, some brain structures (e.g., globus pallidus, thalamus and its nuclei) can be extracted more accurately by…

Computer Vision and Pattern Recognition · Computer Science 2019-03-12 Juan Eugenio Iglesias , Koen Van Leemput , Polina Golland , Anastasia Yendiki

Latent manifolds provide a compact characterization of neural population activity and of shared co-variability across brain areas. Nonetheless, existing statistical tools for extracting neural manifolds face limitations in terms of…

Neurons and Cognition · Quantitative Biology 2022-09-08 Edoardo Balzani , Jean Paul Noel , Pedro Herrero-Vidal , Dora E. Angelaki , Cristina Savin

Imaging genetics is a growing field that employs structural or functional neuroimaging techniques to study individuals with genetic risk variants potentially linked to specific illnesses. This area presents considerable challenges to…

Applications · Statistics 2024-12-31 Siqiang Su , Zhenghao Li , Long Feng , Ting Li

Functional brain networks are well described and estimated from data with Gaussian Graphical Models (GGMs), e.g. using sparse inverse covariance estimators. Comparing functional connectivity of subjects in two populations calls for…

Machine Learning · Statistics 2016-11-21 Eugene Belilovsky , Gaël Varoquaux , Matthew B. Blaschko

The application of machine learning algorithms to the diagnosis and analysis of Alzheimer's disease (AD) from multimodal neuroimaging data is a current research hotspot. It remains a formidable challenge to learn brain region information…

Image and Video Processing · Electrical Eng. & Systems 2022-08-11 Yongcheng Zong , Changhong Jing , Qiankun Zuo

Medical imaging studies have collected high dimensional imaging data to identify imaging biomarkers for diagnosis, screening, and prognosis, among many others. These imaging data are often represented in the form of a multi-dimensional…

Applications · Statistics 2017-11-09 Michelle F. Miranda , Hongtu Zhu , Joseph G. Ibrahim

Template estimation plays a crucial role in computational anatomy since it provides reference frames for performing statistical analysis of the underlying anatomical population variability. While building models for template estimation,…

Computer Vision and Pattern Recognition · Computer Science 2017-05-02 Akshay Pai , Stefan Sommer , Lars Lau Raket , Line Kühnel , Sune Darkner , Lauge Sørensen , Mads Nielsen

Multi-task learning has emerged as a powerful machine learning paradigm for integrating data from multiple sources, leveraging similarities between tasks to improve overall model performance. However, the application of multi-task learning…

Methodology · Statistics 2024-02-09 Parker Knight , Rui Duan

In nonparametric regression problems involving multiple predictors, there is typically interest in estimating an anisotropic multivariate regression surface in the important predictors while discarding the unimportant ones. Our focus is on…

Statistics Theory · Mathematics 2015-03-19 Anirban Bhattacharya , Debdeep Pati , David Dunson

The Gaussian graphical model is a widely used tool for learning gene regulatory networks with high-dimensional gene expression data. Most existing methods for Gaussian graphical models assume that the data are homogeneous, i.e., all samples…

Methodology · Statistics 2018-05-08 Bochao Jia , Faming Liang

We propose a regression model for non-central $\chi$ (NC-$\chi$) distributed functional magnetic resonance imaging (fMRI) and diffusion weighted imaging (DWI) data, with the heteroscedastic Rician regression model as a prominent special…

Applications · Statistics 2016-12-22 Bertil Wegmann , Anders Eklund , Mattias Villani

We consider the problem of estimating high-dimensional Gaussian graphical models corresponding to a single set of variables under several distinct conditions. This problem is motivated by the task of recovering transcriptional regulatory…

Machine Learning · Statistics 2014-01-24 Karthik Mohan , Palma London , Maryam Fazel , Daniela Witten , Su-In Lee

A central question in neuroscience is how self-organizing dynamic interactions in the brain emerge on their relatively static structural backbone. Due to the complexity of spatial and temporal dependencies between different brain areas,…

Neurons and Cognition · Quantitative Biology 2020-10-15 Simon Wein , Wilhelm Malloni , Ana Maria Tomé , Sebastian M. Frank , Gina-Isabelle Henze , Stefan Wüst , Mark W. Greenlee , Elmar W. Lang
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