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The thalamus and its constituent nuclei are critical for a broad range of cognitive and sensorimotor processes, and implicated in many neurological and neurodegenerative conditions. However, the functional involvement and specificity of…

Image and Video Processing · Electrical Eng. & Systems 2023-09-27 Brendan Williams , Dan Nguyen , Julie Vidal , Alzheimer's Disease Neuroimaging Initiative , Manojkumar Saranathan

Accurate thalamic nuclei segmentation is crucial for understanding neurological diseases, brain functions, and guiding clinical interventions. However, the optimal inputs for segmentation remain unclear. This study systematically evaluates…

Image and Video Processing · Electrical Eng. & Systems 2025-08-19 Anqi Feng , Zhangxing Bian , Samuel W. Remedios , Savannah P. Hays , Blake E. Dewey , Jiachen Zhuo , Dan Benjamini , Jerry L. Prince

The thalamus consists of several histologically and functionally distinct nuclei increasingly implicated in brain pathology and important for treatment, motivating the need for development of fast and accurate thalamic segmentation. The…

Image and Video Processing · Electrical Eng. & Systems 2019-12-19 Charles Iglehart , Martin Monti , Joshua Cain , Thomas Tourdias , Manojkumar Saranathan

The thalamus is a subcortical gray matter structure that plays a key role in relaying sensory and motor signals within the brain. Its nuclei can atrophy or otherwise be affected by neurological disease and injuries including mild traumatic…

Image and Video Processing · Electrical Eng. & Systems 2023-02-02 Chang Yan , Muhan Shao , Zhangxing Bian , Anqi Feng , Yuan Xue , Jiachen Zhuo , Rao P. Gullapalli , Aaron Carass , Jerry L. Prince

The thalamus is a subcortical structure of central importance to brain function, which is organized in smaller nuclei with specialized roles. Despite significant functional and clinical relevance, locating and distinguishing the different…

Accurate segmentation of thalamic nuclei from magnetic resonance images is important due to the distinct roles of these nuclei in overall brain function and to their differential involvement in neurological and psychiatric disorders.…

Image and Video Processing · Electrical Eng. & Systems 2025-12-08 Anqi Feng , Zhangxing Bian , Samuel W. Remedios , Savannah P. Hays , Blake E. Dewey , Alexa Colinco , Jiachen Zhuo , Dan Benjamini , Jerry L. Prince

Accurate segmentation of thalamic nuclei is important for better understanding brain function and improving disease treatment. Traditional segmentation methods often rely on a single T1-weighted image, which has limited contrast in the…

Image and Video Processing · Electrical Eng. & Systems 2024-09-12 Anqi Feng , Zhangxing Bian , Blake E. Dewey , Alexa Gail Colinco , Jiachen Zhuo , Jerry L. Prince

The human thalamus is a highly connected subcortical grey-matter structure within the brain. It comprises dozens of nuclei with different function and connectivity, which are affected differently by disease. For this reason, there is…

Accurate segmentation of thalamic nuclei, crucial for understanding their role in healthy cognition and in pathologies, is challenging to achieve on standard T1-weighted (T1w) magnetic resonance imaging (MRI) due to poor image contrast.…

Image and Video Processing · Electrical Eng. & Systems 2023-04-17 Julie P. Vidal , Lola Danet , Patrice Péran , Jérémie Pariente , Meritxell Bach Cuadra , Natalie M. Zahr , Emmanuel J. Barbeau , Manojkumar Saranathan

A cascaded multi-planar scheme with a modified residual U-Net architecture was used to segment thalamic nuclei on conventional and white-matter-nulled (WMn) magnetization prepared rapid gradient echo (MPRAGE) data. A single network was…

Image and Video Processing · Electrical Eng. & Systems 2020-08-26 Mohammad S Majdi , Mahesh B Keerthivasan , Brian K Rutt , Natalie M Zahr , Jeffrey J Rodriguez , Manojkumar Saranathan

The implication of the thalamus in multiple neurological pathologies makes it a structure of interest for volumetric analysis. In the present work, we have designed and implemented a multimodal volumetric deep neural network for the…

The diagnosis and segmentation of tumors using any medical diagnostic tool can be challenging due to the varying nature of this pathology. Magnetic Reso- nance Imaging (MRI) is an established diagnostic tool for various diseases and…

Computer Vision and Pattern Recognition · Computer Science 2017-11-01 Tanvi Gupta , Pranay Manocha , Tapan K. Gandhi , RK Gupta , BK Panigrahi

Thalamic nuclei have been implicated in several neurological diseases. WMn-MPRAGE images have been shown to provide better intra-thalamic nuclear contrast compared to conventional MPRAGE images but the additional acquisition results in…

Machine Learning · Computer Science 2020-12-18 Lavanya Umapathy , Mahesh Bharath Keerthivasan , Natalie M. Zahr , Ali Bilgin , Manojkumar Saranathan

Segmentation of structural and diffusion MRI (sMRI/dMRI) is usually performed independently in neuroimaging pipelines. However, some brain structures (e.g., globus pallidus, thalamus and its nuclei) can be extracted more accurately by…

Computer Vision and Pattern Recognition · Computer Science 2019-03-12 Juan Eugenio Iglesias , Koen Van Leemput , Polina Golland , Anastasia Yendiki

Purpose: Thalamic nuclei are largely invisible in conventional MRI due to poor contrast. Thalamus Optimized Multi-Atlas Segmentation (THOMAS) provides automatic segmentation of 12 thalamic nuclei using white-matter-nulled (WMn) MPRAGE…

Image and Video Processing · Electrical Eng. & Systems 2020-06-30 Ritobrato Datta , Micky K. Bacchus , Dushyant Kumar , Mark A. Elliott , Aditya Rao , Sudipto Dolui , Ravinder Reddy , Brenda L Banwell , Manojkumar Saranathan

Here we present a method for the simultaneous segmentation of white matter lesions and normal-appearing neuroanatomical structures from multi-contrast brain MRI scans of multiple sclerosis patients. The method integrates a novel model for…

Image and Video Processing · Electrical Eng. & Systems 2020-11-26 Stefano Cerri , Oula Puonti , Dominik S. Meier , Jens Wuerfel , Mark Mühlau , Hartwig R. Siebner , Koen Van Leemput

A key feature of magnetic resonance (MR) imaging is its ability to manipulate how the intrinsic tissue parameters of the anatomy ultimately contribute to the contrast properties of the final, acquired image. This flexibility, however, can…

Computer Vision and Pattern Recognition · Computer Science 2018-11-20 Dzung L. Pham , Snehashis Roy

Multimodal Magnetic Resonance Imaging (MRI) provides essential complementary information for analyzing brain tumor subregions. While methods using four common MRI modalities for automatic segmentation have shown success, they often face…

Image and Video Processing · Electrical Eng. & Systems 2024-11-14 Runze Cheng , Zhongao Sun , Ye Zhang , Chun Li

The segmentation of lesions in Moderate to Severe Traumatic Brain Injury (msTBI) presents a significant challenge in neuroimaging due to the diverse characteristics of these lesions, which vary in size, shape, and distribution across brain…

Computer Vision and Pattern Recognition · Computer Science 2025-04-10 Constantin Ulrich , Tassilo Wald , Fabian Isensee , Klaus H. Maier-Hein

Multi-contrast magnetic resonance imaging (MRI) plays a vital role in brain tumor segmentation and diagnosis by leveraging complementary information from different contrasts. Each contrast highlights specific tumor characteristics, enabling…

Image and Video Processing · Electrical Eng. & Systems 2025-03-10 Zhenxuan Zhang , Hongjie Wu , Jiahao Huang , Baihong Xie , Zhifan Gao , Junxian Du , Pete Lally , Guang Yang
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