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Large-scale {\it in vitro} drug sensitivity screens are an important tool in personalized oncology to predict the effectiveness of potential cancer drugs. The prediction of the sensitivity of cancer cell lines to a panel of drugs is a…

Methodology · Statistics 2020-03-10 Zhi Zhao , Manuela Zucknick

Low-rank regularization (LRR) has been widely applied in various machine learning tasks, but the associated optimization is challenging. Directly optimizing the rank function under constraints is NP-hard in general. To overcome this…

Machine Learning · Computer Science 2025-05-22 Naiqi Li , Yuqiu Xie , Peiyuan Liu , Tao Dai , Yong Jiang , Shu-Tao Xia

Representation based classification (RC) methods such as sparse RC (SRC) have shown great potential in face recognition in recent years. Most previous RC methods are based on the conventional regression models, such as lasso regression,…

Computer Vision and Pattern Recognition · Computer Science 2017-11-17 Yulong Wang , Yuan Yan Tang , Luoqing Li , Hong Chen

This paper presents a computationally feasible method to compute rigorous bounds on the interval-generalisation of regression analysis to account for epistemic uncertainty in the output variables. The new iterative method uses machine…

Data Analysis, Statistics and Probability · Physics 2023-02-22 Krasymyr Tretiak , Georg Schollmeyer , Scott Ferson

In this study, we have developed an incremental machine learning (ML) method that efficiently obtains the optimal model when a small number of instances or features are added or removed. This problem holds practical importance in model…

Machine Learning · Statistics 2023-06-23 Hiroyuki Hanada , Noriaki Hashimoto , Kouichi Taji , Ichiro Takeuchi

This paper studies simultaneous feature selection and extraction in supervised and unsupervised learning. We propose and investigate selective reduced rank regression for constructing optimal explanatory factors from a parsimonious subset…

Methodology · Statistics 2016-10-27 Yiyuan She

Registration networks have shown great application potentials in medical image analysis. However, supervised training methods have a great demand for large and high-quality labeled datasets, which is time-consuming and sometimes impractical…

Computer Vision and Pattern Recognition · Computer Science 2021-05-21 Dengqiang Jia , Shangqi Gao , Qunlong Chen , Xinzhe Luo , Xiahai Zhuang

We consider modeling, inference, and computation for analyzing multivariate binary data. We propose a new model that consists of a low dimensional latent variable component and a sparse graphical component. Our study is motivated by…

Methodology · Statistics 2016-06-30 Yunxiao Chen , Xiaoou Li , Jingchen Liu , Zhiliang Ying

Modern high-dimensional methods often adopt the "bet on sparsity" principle, while in supervised multivariate learning statisticians may face "dense" problems with a large number of nonzero coefficients. This paper proposes a novel…

Machine Learning · Statistics 2022-02-10 Yiyuan She , Jiahui Shen , Chao Zhang

In this paper we study the kernel multiple ridge regression framework, which we refer to as multi-task regression, using penalization techniques. The theoretical analysis of this problem shows that the key element appearing for an optimal…

Statistics Theory · Mathematics 2012-10-25 Matthieu Solnon , Sylvain Arlot , Francis Bach

We consider robust low rank matrix estimation as a trace regression when outputs are contaminated by adversaries. The adversaries are allowed to add arbitrary values to arbitrary outputs. Such values can depend on any samples. We deal with…

Machine Learning · Statistics 2024-05-27 Takeyuki Sasai , Hironori Fujisawa

This study proposes a mathematical programming-based algorithm for the integrated selection of variable subsets and bandwidth estimation in geographically weighted regression, a local regression method that allows the kernel bandwidth and…

Methodology · Statistics 2025-03-24 Hyunwoo Lee , Young Woong Park

Recently, the low rank and sparse (LRS) matrix decomposition has been introduced as an effective mean to solve the multi-view registration. It views each available relative motion as a block element to reconstruct one matrix so as to…

Computer Vision and Pattern Recognition · Computer Science 2018-04-06 Congcong Jin , Jihua Zhu , Yaochen Li , Shanmin Pang , Lei Chen , Jun Wang

Data integration methods that analyze multiple sources of data simultaneously can often provide more holistic insights than can separate inquiries of each data source. Motivated by the advantages of data integration in the era of "big…

Methodology · Statistics 2020-01-13 Yulia Baker , Tiffany M. Tang , Genevera I. Allen

Graphical Gaussian models are popular tools for the estimation of (undirected) gene association networks from microarray data. A key issue when the number of variables greatly exceeds the number of samples is the estimation of the matrix of…

Methodology · Statistics 2010-08-13 Nicole Kraemer , Juliane Schaefer , Anne-Laure Boulesteix

For data with high-dimensional covariates but small to moderate sample sizes, the analysis of single datasets often generates unsatisfactory results. The integrative analysis of multiple independent datasets provides an effective way of…

Methodology · Statistics 2015-01-19 Yuan Huang , Qingzhao Zhang , Sanguo Zhang , Jian Huang , Shuangge Ma

The Latent Block Model (LBM) is a prominent model-based co-clustering method, returning parametric representations of each block cluster and allowing the use of well-grounded model selection methods. The LBM, while adapted in literature to…

Kernel ridge regression, KRR, is a generalization of linear ridge regression that is non-linear in the data, but linear in the model parameters. Here, we introduce an equivalent formulation of the objective function of KRR, which opens up…

Machine Learning · Statistics 2025-03-10 Oskar Allerbo

Reduced-rank linear discriminant analysis (RRLDA) is a foundational method of dimension reduction for classification that has been useful in a wide range of applications. The goal is to identify an optimal subspace to project the…

Computation · Statistics 2026-02-12 Jocelyn T. Chi

We consider the problem of non-parametric regression with a potentially large number of covariates. We propose a convex, penalized estimation framework that is particularly well-suited for high-dimensional sparse additive models. The…

Methodology · Statistics 2019-06-19 Asad Haris , Ali Shojaie , Noah Simon