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Humans and animals learn throughout life. Such continual learning is crucial for intelligence. In this chapter, we examine the pivotal role plasticity mechanisms with complex internal synaptic dynamics could play in enabling this ability in…

Neurons and Cognition · Quantitative Biology 2024-10-21 Friedemann Zenke , Axel Laborieux

With memory encoding reliant on persistent changes in the properties of synapses, a key question is how can memories be maintained from days to months or a lifetime given molecular turnover? It is likely that positive feedback loops are…

Neurons and Cognition · Quantitative Biology 2019-04-18 Paul Smolen , Douglas A. Baxter , John H. Byrne

Human social life is shaped by repeated interactions, where past experiences guide future behavior. In evolutionary game theory, a key challenge is to identify strategies that harness such memory to succeed in repeated encounters. Decades…

Populations and Evolution · Quantitative Biology 2025-09-16 Ketian Sun , Qi Su , Long Wang

LLMs are trained once, then deployed into a world that never stops changing. External memory compensates for this, but most systems manage it explicitly rather than letting it adapt on its own. Biological memory works differently: coupled…

Machine Learning · Computer Science 2026-05-08 Andreas Pattichis , Constantine Dovrolis

The standard consolidation theory states that short-term memories located in the hippocampus enable the consolidation of long-term memories in the neocortex. In other words, the neocortex slowly learns long-term memories with a transient…

Neurons and Cognition · Quantitative Biology 2024-04-05 Lisa Blum Moyse , Hugues Berry

Despite substantial research into the biological basis of memory, the precise mechanisms by which experiences are encoded, stored, and retrieved in the brain remain incompletely understood. A growing body of evidence supports the engram…

Neural and Evolutionary Computing · Computer Science 2025-10-28 Daniel Szelogowski

Dense associative memory, a fundamental instance of modern Hopfield networks, can store a large number of memory patterns as equilibrium states of recurrent networks. While the stationary-state storage capacity has been investigated, its…

Disordered Systems and Neural Networks · Physics 2025-10-29 Kazushi Mimura , Jun'ichi Takeuchi , Yuto Sumikawa , Yoshiyuki Kabashima , Anthony C. C. Coolen

In the mammalian brain, newly acquired memories depend on the hippocampus for maintenance and recall, but over time the neocortex takes over these functions, rendering memories hippocampus-independent. The process responsible for this…

Neurons and Cognition · Quantitative Biology 2021-07-02 Peter Helfer , Thomas R. Shultz

Storage and retrieval of data in a computer memory plays a major role in system performance. Traditionally, computer memory organization is static - i.e., they do not change based on the application-specific characteristics in memory access…

Artificial Intelligence · Computer Science 2021-01-11 Prabuddha Chakraborty , Swarup Bhunia

Learning is based on synaptic plasticity, which affects and is driven by neural activity. Because pre- and postsynaptic spiking activity is shaped by randomness, the synaptic weights follow a stochastic process, requiring a probabilistic…

Neurons and Cognition · Quantitative Biology 2026-01-14 Jakob Stubenrauch , Naomi Auer , Richard Kempter , Benjamin Lindner

Collective rhythmic dynamics from neurons is vital for cognitive functions such as memory formation but how neurons self-organize to produce such activity is not well understood. Attractor-based models have been successfully implemented as…

Neurons and Cognition · Quantitative Biology 2013-03-22 Mark Niedringhaus , Xin Chen , Katherine Conant , Rhonda Dzakpasu

We analyze continuous Hopfield associative memories augmented by additional, rapid short-term associative synaptic plasticity. Through the cavity method, we determine the boundary between the retrieval and forgetting, or spin-glass phase,…

Neurons and Cognition · Quantitative Biology 2026-02-10 Martina Del Gaudio , Federico Ghimenti , Surya Ganguli

We study the collective dynamics of a Leaky Integrate and Fire network in which precise relative phase relationship of spikes among neurons are stored, as attractors of the dynamics, and selectively replayed at differentctime scales. Using…

Neurons and Cognition · Quantitative Biology 2012-10-26 Silvia Scarpetta , Ferdinando Giacco

Self-sustained, elevated neuronal activity persisting on time scales of ten seconds or longer is thought to be vital for aspects of working memory, including brain representations of real space. Continuous-attractor neural networks, one of…

Neurons and Cognition · Quantitative Biology 2020-08-19 Joseph L. Natale , H. George E. Hentschel , Ilya Nemenman

Protein synthesis-dependent, late long-term potentiation (LTP) and depression (LTD) at glutamatergic hippocampal synapses are well characterized examples of long-term synaptic plasticity. Persistent increased activity of the enzyme protein…

Neurons and Cognition · Quantitative Biology 2015-03-13 Paul Smolen , Douglas A. Baxter , John H. Byrne

Learning and memory relies on synapses changing their strengths in response to neural activity. However there is a substantial gap between the timescales of neural electrical dynamics (1-100 ms) and organism behaviour during learning…

Neurons and Cognition · Quantitative Biology 2023-08-08 Cian O'Donnell

Short-term memory is essential for cognitive processing, yet our understanding of its neural mechanisms remains unclear. Neuroscience has long focused on how sequential activity patterns, where neurons fire one after another within large…

We propose a single chunk model of long-term memory that combines the basic features of the ACT-R theory and the multiple trace memory architecture. The pivot point of the developed theory is a mathematical description of the creation of…

Neurons and Cognition · Quantitative Biology 2014-02-18 Ihor Lubashevsky , Bohdan Datsko

We study the effect of competition between short-term synaptic depression and facilitation on the dynamical properties of attractor neural networks, using Monte Carlo simulation and a mean field analysis. Depending on the balance between…

Neurons and Cognition · Quantitative Biology 2007-05-23 J. J. Torres , J. M. Cortes , J. Marro , H. J. Kappen

Working memory is a cognitive function involving the storage and manipulation of latent information over brief intervals of time, thus making it crucial for context-dependent computation. Here, we use a top-down modeling approach to examine…

Neurons and Cognition · Quantitative Biology 2021-11-17 Elham Ghazizadeh , ShiNung Ching