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Boolean networks are special types of finite state time-discrete dynamical systems. A Boolean network can be described by a function from an n-dimensional vector space over the field of two elements to itself. A fundamental problem in…

Quantitative Methods · Quantitative Biology 2013-07-03 Yi Ming Zou

The minimum number of inputs needed to control a network is frequently used to quantify its controllability. Control of linear dynamics through a minimum set of inputs, however, often has prohibitively large energy requirements and there is…

Computational Engineering, Finance, and Science · Computer Science 2022-12-12 Samie Alizadeh , Márton Pósfai , Abdorasoul Ghasemi

Boolean networks are dynamical models of disease development in which the activation levels of genes are represented by binary variables. Given a Boolean network, controls represent mutations or medical treatments that fix the activation…

Optimization and Control · Mathematics 2026-04-02 Kyungduk Moon , Kangbok Lee , Loïc Paulevé

This paper studies the minimum control node set problem for Boolean networks (BNs) with degree constraints. The main contribution is to derive the nontrivial lower and upper bounds on the size of the minimum control node set through…

Systems and Control · Electrical Eng. & Systems 2026-03-03 Liangjie Sun , Wai-Ki Ching , Tatsuya Akutsu

Observing and controlling complex networks are of paramount interest for understanding complex physical, biological and technological systems. Recent studies have made important advances in identifying sensor or driver nodes, through which…

Deciding what to sense is a crucial task, made harder by dependencies and by a nonadditive utility function. We develop approximation algorithms for selecting an optimal set of measurements, under a dependency structure modeled by a…

Artificial Intelligence · Computer Science 2012-06-18 Yan Radovilsky , Solomon Eyal Shimony

Observability of complex systems/networks is the focus of this paper, which is shown to be closely related to the concept of contraction. Indeed, for observable network tracking it is necessary/sufficient to have one node in each…

Systems and Control · Computer Science 2017-09-13 Mohammadreza Doostmohammadian , Hamid R. Rabiee , Houman Zarrabi , Usman Khan

This paper studies the controllability backbone problem in dynamical networks defined over graphs. The main idea of the controllability backbone is to identify a small subset of edges in a given network such that any subnetwork containing…

Systems and Control · Electrical Eng. & Systems 2023-09-07 Obaid Ullah Ahmad , Waseem Abbas , Mudassir Shabbir

We revisit the elegant observation of T. Cover '65 which, perhaps, is not as well-known to the broader community as it should be. The first goal of the tutorial is to explain---through the prism of this elementary result---how to solve…

Machine Learning · Computer Science 2016-09-01 Alexander Rakhlin , Karthik Sridharan

In this paper, we analyse large random Boolean networks in terms of a constraint satisfaction problem. We first develop an algorithmic scheme which allows to prune simple logical cascades and under-determined variables, returning thereby…

Statistical Mechanics · Physics 2009-11-11 L. Correale , M. Leone , A. Pagnani , M. Weigt , R. Zecchina

In the applications of Boolean networks to modeling biological systems, an important computational problem is the detection of the fixed points of these networks. This is an NP-complete problem in general. There have been various attempts…

Quantitative Methods · Quantitative Biology 2014-04-23 Yi Ming Zou

Regulatory networks (RNs) are a well-accepted modelling formalism in computational systems biology. The control of RNs is currently receiving a lot of attention because it provides a computational basis for cell reprogramming -- an…

Systems and Control · Electrical Eng. & Systems 2022-03-01 Luboš Brim , Samuel Pastva , David Šafránek , Eva Šmijáková

Boolean automata networks (aka Boolean networks) are space-time discrete dynamical systems, studied as a model of computation and as a representative model of natural phenomena. A collection of simple entities (the automata) update their…

Discrete Mathematics · Computer Science 2024-02-12 Kévin Perrot , Sylvain Sené , Léah Tapin

Boolean networks (BNs) are discrete-time systems where nodes are inter-connected (here we call such connection rule among nodes as network structure), and the dynamics of each gene node is determined by logical functions. In this paper, we…

Systems and Control · Electrical Eng. & Systems 2020-11-03 Jie Zhong , Daniel W. C. Ho , Jianquan Lu

We present and discuss the results of an experimental analysis in the design of Boolean networks by means of genetic algorithms. A population of networks is evolved with the aim of finding a network such that the attractor it reaches is of…

Neural and Evolutionary Computing · Computer Science 2011-02-01 Andrea Roli , Cristian Arcaroli , Marco Lazzarini , Stefano Benedettini

We investigate graphs that can be disconnected into small components by removing a vanishingly small fraction of their vertices. We show that when a quantum network is described by such a graph, the network is efficiently controllable, in…

Quantum Physics · Physics 2017-07-05 Can Gokler , Seth Lloyd , Peter Shor , Kevin Thompson

The study of network structure has uncovered signatures of the organization of complex systems. However, there is also a need to understand how to control them; for example, identifying strategies to revert a diseased cell to a healthy…

Molecular Networks · Quantitative Biology 2016-04-19 Alexander J. Gates , Luis M. Rocha

Boolean networks is a well-established formalism for modelling biological systems. A vital challenge for analysing a Boolean network is to identify all the attractors. This becomes more challenging for large asynchronous Boolean networks,…

Molecular Networks · Quantitative Biology 2017-06-14 Andrzej Mizera , Jun Pang , Hongyang Qu , Qixia Yuan

Observability and controllability are essential concepts to the design of predictive observer models and feedback controllers of networked systems. For example, noncontrollable mathematical models of real systems have subspaces that…

Neurons and Cognition · Quantitative Biology 2018-04-18 Andrew J. Whalen , Sean N. Brennan , Timothy D. Sauer , Steven J. Schiff

It has been shown that self-triggered control has the ability to reduce computational loads and deal with the cases with constrained resources by properly setting up the rules for updating the system control when necessary. In this paper,…

Systems and Control · Electrical Eng. & Systems 2020-07-07 Min Meng , Gaoxi Xiao , Daizhan Cheng