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Deep neural networks (DNNs) achieve promising performance in visual recognition under the independent and identically distributed (IID) hypothesis. In contrast, the IID hypothesis is not universally guaranteed in numerous real-world…

Image and Video Processing · Electrical Eng. & Systems 2023-06-27 Shuai Wang , Zipei Yan , Daoan Zhang , Zhongsen Li , Sirui Wu , Wenxuan Chen , Rui Li

Medical image segmentation models are often trained on curated datasets, leading to performance degradation when deployed in real-world clinical settings due to mismatches between training and test distributions. While data augmentation…

Computer Vision and Pattern Recognition · Computer Science 2025-05-16 Puru Vaish , Felix Meister , Tobias Heimann , Christoph Brune , Jelmer M. Wolterink

Reliable uncertainty quantification is crucial for trustworthy decision-making and the deployment of AI models in medical imaging. While prior work has explored the ability of neural networks to quantify predictive, epistemic, and aleatoric…

Machine Learning · Statistics 2025-08-07 Simon Baur , Wojciech Samek , Jackie Ma

Lung cancer is the leading cause of cancer related mortality by a significant margin. While new technologies, such as image segmentation, have been paramount to improved detection and earlier diagnoses, there are still significant…

Computer Vision and Pattern Recognition · Computer Science 2022-09-20 Marguerite B. Basta , Sarfaraz Hussein , Hsiang Hsu , Flavio P. Calmon

PET imaging is widely employed for observing biological metabolic activities within the human body. However, numerous benign conditions can cause increased uptake of radiopharmaceuticals, confounding differentiation from malignant tumors.…

Image and Video Processing · Electrical Eng. & Systems 2024-10-31 Ran Hong , Yuxia Huang , Lei Liu , Zhonghui Wu , Bingxuan Li , Xuemei Wang , Qiegen Liu

Deep unrolling is an emerging deep learning-based image reconstruction methodology that bridges the gap between model-based and purely deep learning-based image reconstruction methods. Although deep unrolling methods achieve…

Image and Video Processing · Electrical Eng. & Systems 2022-12-21 Canberk Ekmekci , Mujdat Cetin

Deep learning models are being adopted and applied on various critical decision-making tasks, yet they are trained to provide point predictions without providing degrees of confidence. The trustworthiness of deep learning models can be…

Machine Learning · Computer Science 2024-10-28 Daniel Nolte , Souparno Ghosh , Ranadip Pal

In this paper we address the uncertainty issues involved in the low-level vision task of image segmentation. Researchers in computer vision have worked extensively on this problem, in which the goal is to partition (or segment) an image…

Artificial Intelligence · Computer Science 2013-03-08 Steven M. LaValle , Seth A. Hutchinson

Deep convolutional neural networks (CNNs) have shown excellent performance in object recognition tasks and dense classification problems such as semantic segmentation. However, training deep neural networks on large and sparse datasets is…

Computer Vision and Pattern Recognition · Computer Science 2017-12-25 Lorenz Berger , Eoin Hyde , M. Jorge Cardoso , Sebastien Ourselin

Clinical decision requires reasoning in the presence of imperfect data. DTs are a well-known decision support tool, owing to their interpretability, fundamental in safety-critical contexts such as medical diagnosis. However, learning DTs…

This paper proposes a two-stage segmentation model, variable-input based uncertainty measures and an uncertainty-guided post-processing method for prostate segmentation on 3D magnetic resonance images (MRI). The two-stage model was based on…

Computer Vision and Pattern Recognition · Computer Science 2019-03-07 Huitong Pan , Yushan Feng , Quan Chen , Craig Meyer , Xue Feng

Uncertainty in medical image segmentation is inherently non-uniform, with boundary regions exhibiting substantially higher ambiguity than interior areas. Conventional training treats all pixels equally, leading to unstable optimization…

Computer Vision and Pattern Recognition · Computer Science 2026-02-25 Jinming Zhang , Youpeng Yang , Xi Yang , Haosen Shi , Yuyao Yan , Qiufeng Wang , Guangliang Cheng , Kaizhu Huang

The accurate estimation of predictive uncertainty carries importance in medical scenarios such as lung node segmentation. Unfortunately, most existing works on predictive uncertainty do not return calibrated uncertainty estimates, which…

Machine Learning · Computer Science 2022-05-31 Shi Hu , Daniel Worrall , Stefan Knegt , Bas Veeling , Henkjan Huisman , Max Welling

Deploying deep learning (DL) models in medical applications relies on predictive performance and other critical factors, such as conveying trustworthy predictive uncertainty. Uncertainty estimation (UE) methods provide potential solutions…

Image and Video Processing · Electrical Eng. & Systems 2024-03-26 Kudaibergen Abutalip , Numan Saeed , Ikboljon Sobirov , Vincent Andrearczyk , Adrien Depeursinge , Mohammad Yaqub

Image segmentation is a fundamental and challenging problem in computer vision with applications spanning multiple areas, such as medical imaging, remote sensing, and autonomous vehicles. Recently, convolutional neural networks (CNNs) have…

Computer Vision and Pattern Recognition · Computer Science 2020-06-24 Ali Hatamizadeh

This paper investigates the use of probabilistic neural networks (PNNs) to model aleatoric uncertainty, which refers to the inherent variability in the input-output relationships of a system, often characterized by unequal variance or…

Machine Learning · Statistics 2024-02-22 Farhad Pourkamali-Anaraki , Jamal F. Husseini , Scott E. Stapleton

Image-based precision medicine aims to personalize treatment decisions based on an individual's unique imaging features so as to improve their clinical outcome. Machine learning frameworks that integrate uncertainty estimation as part of…

Machine Learning · Computer Science 2023-08-11 Joshua Durso-Finley , Jean-Pierre Falet , Raghav Mehta , Douglas L. Arnold , Nick Pawlowski , Tal Arbel

Machine Learning (ML) has emerged as a promising approach in healthcare, outperforming traditional statistical techniques. However, to establish ML as a reliable tool in clinical practice, adherence to best practices regarding data…

Image and Video Processing · Electrical Eng. & Systems 2023-09-15 Rosanna Turrisi , Alessandro Verri , Annalisa Barla

Trustworthy artificial intelligence (AI) is essential in healthcare, particularly for high-stakes tasks like medical image segmentation. Explainable AI and uncertainty quantification significantly enhance AI reliability by addressing key…

Classifying subjects as healthy or diseased using neuroimaging data has gained a lot of attention during the last 10 years. Here we apply deep learning to derivatives from resting state fMRI data, and investigate how different 3D…

Image and Video Processing · Electrical Eng. & Systems 2021-10-22 Johan Jönemo , David Abramian , Anders Eklund