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This paper proposes the importance of age and gender information in the diagnosis of diabetic retinopathy. We utilized Deep Residual Neural Networks (ResNet) and Densely Connected Convolutional Networks (DenseNet), which are proven…

Image and Video Processing · Electrical Eng. & Systems 2023-02-14 Long Bai , Sihang Chen , Mingyang Gao , Leila Abdelrahman , Manal Al Ghamdi , Mohamed Abdel-Mottaleb

Dementia, a progressive neurodegenerative disorder, affects memory, reasoning, and daily functioning, creating challenges for individuals and healthcare systems. Early detection is crucial for timely interventions that may slow disease…

Neurons and Cognition · Quantitative Biology 2025-03-04 Sahar Sinene Mehdoui , Abdelhamid Bouzid , Daniel Sierra-Sosa , Adel Elmaghraby

Age-related macular degeneration (AMD) is a major cause of blindness in older adults, severely affecting vision and quality of life. Despite advances in understanding AMD, the molecular factors driving the severity of subretinal scarring…

Genomics · Quantitative Biology 2024-09-10 Kuan Yan , Yue Zeng , Dai Shi , Ting Zhang , Dmytro Matsypura , Mark C. Gillies , Ling Zhu , Junbin Gao

Deep neural networks are representation learning techniques. During training, a deep net is capable of generating a descriptive language of unprecedented size and detail in machine learning. Extracting the descriptive language coded within…

Neural and Evolutionary Computing · Computer Science 2018-01-30 Dario Garcia-Gasulla , Ferran Parés , Armand Vilalta , Jonatan Moreno , Eduard Ayguadé , Jesús Labarta , Ulises Cortés , Toyotaro Suzumura

One of the pursued objectives of deep learning is to provide tools that learn abstract representations of reality from the observation of multiple contextual situations. More precisely, one wishes to extract disentangled representations…

Machine Learning · Computer Science 2023-10-24 Pierre Colombo , Nathan Noiry , Guillaume Staerman , Pablo Piantanida

The current state-of-the-art deep neural networks (DNNs) for Alzheimer's Disease diagnosis use different biomarker combinations to classify patients, but do not allow extracting knowledge about the interactions of biomarkers. However, to…

Machine Learning · Computer Science 2021-09-28 Raphael Ronge , Kwangsik Nho , Christian Wachinger , Sebastian Pölsterl

Depression is a common yet serious mental disorder that affects millions of U.S. high schoolers every year. Still, accurate diagnosis and early detection remain significant challenges. In the field of public health, research shows that…

Machine Learning · Computer Science 2023-08-23 Nathan Zhong , Nikhil Yadav

Joint models are used in ageing studies to investigate the association between longitudinal markers and a time-to-event, and have been extended to multiple markers and/or competing risks. The competing risk of death must be considered in…

\textbf{Objectives}: We aimed to investigate how errors from automatic speech recognition (ASR) systems affect dementia classification accuracy, specifically in the ``Cookie Theft'' picture description task. We aimed to assess whether…

Computation and Language · Computer Science 2024-01-12 Changye Li , Weizhe Xu , Trevor Cohen , Serguei Pakhomov

Machine-learning-based age estimation has received lots of attention. Traditional age estimation mechanism focuses estimation age error, but ignores that there is a deviation between the estimated age and real age due to disease.…

Computer Vision and Pattern Recognition · Computer Science 2021-03-12 Fan Li , Yongming Li , Pin Wang , Jie Xiao , Fang Yan , Xinke Li

Dementia and especially Alzheimer's disease (AD) are the most common causes of cognitive decline in elderly people. A spread of the above mentioned mental health problems in aging societies is causing a significant medical and economic…

Neurons and Cognition · Quantitative Biology 2018-12-03 Tomasz M. Rutkowski , Qibin Zhao , Masao S. Abe , Mihoko Otake

In this article, we provide an experimental observation: Deep neural network (DNN) based speech quality assessment (SQA) models have inherent latent representations where many types of impairments are clustered. While DNN-based SQA models…

Audio and Speech Processing · Electrical Eng. & Systems 2025-05-01 Fredrik Cumlin , Xinyu Liang , Victor Ungureanu , Chandan K. A. Reddy , Christian Schüldt , Saikat Chatterjee

Structural magnetic resonance imaging (MRI) studies have shown that Alzheimer's Disease (AD) induces both localised and widespread neural degenerative changes throughout the brain. However, the absence of segmentation that highlights brain…

Image and Video Processing · Electrical Eng. & Systems 2024-06-21 Chen Zheng

Whisper fails to correctly transcribe dementia speech because persons with dementia (PwDs) often exhibit irregular speech patterns and disfluencies such as pauses, repetitions, and fragmented sentences. It was trained on standard speech and…

Audio and Speech Processing · Electrical Eng. & Systems 2025-05-29 Emmanuel Akinrintoyo , Nadine Abdelhalim , Nicole Salomons

Learning a disentangled representation of the latent space has become one of the most fundamental problems studied in computer vision. Recently, many Generative Adversarial Networks (GANs) have shown promising results in generating high…

Computer Vision and Pattern Recognition · Computer Science 2021-04-29 Kumar Shubham , Gopalakrishnan Venkatesh , Reijul Sachdev , Akshi , Dinesh Babu Jayagopi , G. Srinivasaraghavan

Machine learning analysis of longitudinal neuroimaging data is typically based on supervised learning, which requires a large number of ground-truth labels to be informative. As ground-truth labels are often missing or expensive to obtain…

Machine Learning · Computer Science 2021-06-29 Qingyu Zhao , Zixuan Liu , Ehsan Adeli , Kilian M. Pohl

Existing research has shown the potential of classifying Alzheimers Disease (AD) from eye-tracking (ET) data with classifiers that rely on task-specific engineered features. In this paper, we investigate whether we can improve on existing…

Computer Vision and Pattern Recognition · Computer Science 2023-09-25 Harshinee Sriram , Cristina Conati , Thalia Field

Despite extensive standardization, diagnostic interviews for mental health disorders encompass substantial subjective judgment. Previous studies have demonstrated that EEG-based neural measures can function as reliable objective correlates…

Machine Learning · Computer Science 2020-11-19 Garrett Honke , Irina Higgins , Nina Thigpen , Vladimir Miskovic , Katie Link , Sunny Duan , Pramod Gupta , Julia Klawohn , Greg Hajcak

Alzheimer's disease (AD) is the most common age-related dementia. It remains a challenge to identify the individuals at risk of dementia for precise management. Brain MRI offers a noninvasive biomarker to detect brain aging. Previous…

Machine Learning · Computer Science 2021-07-26 Chao Li , Yiran Wei , Xi Chen , Carola-Bibiane Schonlieb

Over half of US adults with Alzheimer disease and related dementias remain undiagnosed, and speech-based screening offers a scalable detection approach. We compared large language model adaptation strategies for dementia detection using the…