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In the field of image-based drug discovery, capturing the phenotypic response of cells to various drug treatments and perturbations is a crucial step. However, existing methods require computationally extensive and complex multi-step…

Machine Learning · Computer Science 2025-02-28 Bo Li , Bob Zhang , Chengyang Zhang , Minghao Zhou , Weiliang Huang , Shihang Wang , Qing Wang , Mengran Li , Yong Zhang , Qianqian Song

Large language models (LLMs) are increasingly used to extract structured information from free-text clinical records, but prior work often focuses on single tasks, limited models, and English-language reports. We evaluated 15 open-weight…

Large language models (LLMs) have demonstrated remarkable capabilities for medical question answering and programming, but their potential for generating interpretable computable phenotypes (CPs) is under-explored. In this work, we…

Machine Learning · Computer Science 2025-08-08 Guilherme Seidyo Imai Aldeia , Daniel S. Herman , William G. La Cava

The heterogeneity of data poses a great challenge when data from different sources is to be merged for one application. Solutions for this are offered, for example, by ontology-based data management (OBDM). A challenge of OBDM is the…

Information Retrieval · Computer Science 2020-05-15 Andreas Burgdorf , André Pomp , Tobias Meisen

Natural Language Processing (NLP) systems often make use of machine learning techniques that are unfamiliar to end-users who are interested in analyzing clinical records. Although NLP has been widely used in extracting information from…

Human-Computer Interaction · Computer Science 2017-07-10 Gaurav Trivedi , Phuong Pham , Wendy Chapman , Rebecca Hwa , Janyce Wiebe , Harry Hochheiser

Our objective in this study is to investigate the behavior of Boolean operators on combining annotation output from multiple Natural Language Processing (NLP) systems across multiple corpora and to assess how filtering by aggregation of…

Driven by privacy protection laws and regulations, unlearning in Large Language Models (LLMs) is gaining increasing attention. However, current research often neglects the interpretability of the unlearning process, particularly concerning…

Machine Learning · Computer Science 2025-04-10 Xiaohua Feng , Yuyuan Li , Chengye Wang , Junlin Liu , Li Zhang , Chaochao Chen

We hypothesize that large language models (LLMs) based on the transformer architecture can enable automated detection of clinical phenotype terms, including terms not documented in the HPO. In this study, we developed two types of models:…

Quantitative Methods · Quantitative Biology 2023-11-10 Jingye Yang , Cong Liu , Wendy Deng , Da Wu , Chunhua Weng , Yunyun Zhou , Kai Wang

Current deep neural networks (DNNs) can easily overfit to biased training data with corrupted labels or class imbalance. Sample re-weighting strategy is commonly used to alleviate this issue by designing a weighting function mapping from…

Machine Learning · Computer Science 2019-09-30 Jun Shu , Qi Xie , Lixuan Yi , Qian Zhao , Sanping Zhou , Zongben Xu , Deyu Meng

As the immense opportunities enabled by large language models become more apparent, NLP systems will be increasingly expected to excel in real-world settings. However, in many instances, powerful models alone will not yield translational…

Computation and Language · Computer Science 2023-11-28 Bernal Jimenez Gutierrez , Yuqing Mao , Vinh Nguyen , Kin Wah Fung , Yu Su , Olivier Bodenreider

This research was focused on the efficient collection of experimental Metal-Organic Framework (MOF) data from scientific literature to address the challenges of accessing hard-to-find data and improving the quality of information available…

Materials Science · Physics 2024-04-23 Wonseok Lee , Yeonghun Kang , Taeun Bae , Jihan Kim

Pretrained Language Models (PLMs) have advanced Natural Language Processing (NLP) tasks significantly, but finetuning PLMs on low-resource datasets poses significant challenges such as instability and overfitting. Previous methods tackle…

Computation and Language · Computer Science 2024-03-20 Sai Ashish Somayajula , Youwei Liang , Abhishek Singh , Li Zhang , Pengtao Xie

Multimodal language models (MLLMs) require large parameter capacity to align high-dimensional visual features with linguistic representations, making them computationally heavy and difficult to deploy efficiently. We introduce a progressive…

Computer Vision and Pattern Recognition · Computer Science 2025-12-10 Jawad Ibn Ahad , Maisha Rahman , Amrijit Biswas , Muhammad Rafsan Kabir , Robin Krambroeckers , Sifat Momen , Nabeel Mohammed , Shafin Rahman

Current medical image analysis systems are typically task-specific, requiring separate models for classification and segmentation, and lack the flexibility to support user-defined workflows. To address these challenges, we introduce…

Computer Vision and Pattern Recognition · Computer Science 2026-01-13 Shadman Sobhan , Kazi Abrar Mahmud , Abduz Zami

Large Language Models (LLMs) have demonstrated remarkable performance across various domains, including healthcare. However, their ability to effectively represent structured non-textual data, such as the alphanumeric medical codes used in…

Large Language Models (LLMs) have fundamentally transformed approaches to Natural Language Processing (NLP) tasks across diverse domains. In healthcare, accurate and cost-efficient text classification is crucial, whether for clinical notes…

Computation and Language · Computer Science 2026-02-16 Hajar Sakai , Sarah S. Lam

In this work, we consider the medical concept normalization problem, i.e., the problem of mapping a health-related entity mention in a free-form text to a concept in a controlled vocabulary, usually to the standard thesaurus in the Unified…

Computation and Language · Computer Science 2023-11-21 Zulfat Miftahutdinov , Elena Tutubalina

This paper presents a method for the automated collection and aggregation of unstructured data from diverse web sources, utilizing Large Language Models (LLMs). The primary challenge with existing techniques is their instability when the…

Databases · Computer Science 2026-04-21 Vsevolod Lazebnyi , Natalia Tereshkina , Maria Shabarina , Dmitriy Fedorov

Objective: The generalizability of clinical large language models is usually ignored during the model development process. This study evaluated the generalizability of BERT-based clinical NLP models across different clinical settings…

Computation and Language · Computer Science 2023-03-16 Sicheng Zhou , Nan Wang , Liwei Wang , Ju Sun , Anne Blaes , Hongfang Liu , Rui Zhang

A significant amount of data held in Oncology Electronic Medical Records (EMRs) is contained in unstructured provider notes -- including but not limited to the chemotherapy (or cancer treatment) outcome, different biomarkers, the tumor's…