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The treatment of age-related macular degeneration (AMD) requires continuous eye exams using optical coherence tomography (OCT). The need for treatment is determined by the presence or change of disease-specific OCT-based biomarkers.…

Image and Video Processing · Electrical Eng. & Systems 2026-03-12 Timo Kepp , Helge Sudkamp , Claus von der Burchard , Hendrik Schenke , Peter Koch , Gereon Hüttmann , Johann Roider , Mattias P. Heinrich , Heinz Handels

Optical-coherence tomography (OCT) is a technique that employs light in order to measure the internal structure of semi-transparent, e.g. biological, samples. It is based on the interference pattern of low-coherence light. Quantum-OCT…

Multiple light scattering in tissue limits the penetration of optical coherence tomography (OCT) imaging. Here, we present in-vivo OCT imaging of a live mouse using wavefront shaping to enhance the penetration depth. A digital micro-mirror…

Flexible and fast control of the phase and amplitude of coherent light, enabled by digital micromirror devices (DMDs) and spatial light modulators (SLMs), has been a driving force for recent advances in optical tweezers, nonlinear…

Optics · Physics 2021-07-07 Ruslan Röhrich , Femius Koenderink , Stefan Witte , Lars Loetgering

Diffuse optical tomography (DOT) has been investigated as an alternative imaging modality for breast cancer detection thanks to its excellent contrast to hemoglobin oxidization level. However, due to the complicated non-linear photon…

Computer Vision and Pattern Recognition · Computer Science 2019-09-10 Jaejun Yoo , Sohail Sabir , Duchang Heo , Kee Hyun Kim , Abdul Wahab , Yoonseok Choi , Seul-I Lee , Eun Young Chae , Hak Hee Kim , Young Min Bae , Young-wook Choi , Seungryong Cho , Jong Chul Ye

We demonstrate experimentally quantum-inspired, spectral-domain intensity optical coherence tomography. We show that the technique allows for both axial resolution improvement and dispersion cancellation compared to conventional optical…

Optics · Physics 2015-03-16 Piotr Ryczkowski , Jari Turunen , Ari T. Friberg , Goëry Genty

Quantum-optical coherence tomography (Q-OCT) is an interferometric technique for axial imaging offering several advantages over conventional methods. Chirped-pulse interferometry (CPI) was recently demonstrated to exhibit all of the…

Quantum Physics · Physics 2009-09-07 Jonathan Lavoie , Rainer Kaltenbaek , Kevin J. Resch

Fiber-form optics extends the high-resolution tomographic imaging capabilities of Optical Coherence Tomography (OCT) to the inside of the human body, i.e., endoscopic OCT. However, it still faces challenges due to the trade-off between…

Optics · Physics 2024-09-04 Chengfu Gu , Haoran Zhang , Qi Lan , Weiyi Zhang , Chang Liu , Jianlong Yang

We demonstrate a preliminary setup of a combined MHz-OCT and RGB narrowband reflection microscope and investigate the performance of the new RGB branch and different display modes of colored OCT data sets.

Medical Physics · Physics 2020-08-13 Madita Goeb , Tom Pfeiffer , Robert Huber

This dissertation relates to the transition of the state of the art of swept source optical coherence tomography (SS-OCT) systems to a new realm in which the image acquisition speed is improved by an order of magnitude. With the aid of a…

Image and Video Processing · Electrical Eng. & Systems 2020-02-21 Amir Tofighi Zavareh

The Diffuse Optical Tomography (DOT) has received considerable attention in the recent years in the field of biomedical imaging and disease detection. However, imaging through highly diffusive medium is a challenge and stability is always…

Image and Video Processing · Electrical Eng. & Systems 2020-03-31 Tapan Das , P. K. Dutta

We report a time-domain optical coherence tomography (TD-OCT) system operating in the 2 $\mu\mathrm{m}$ spectral region, enabled by a GaSb-based superluminescent diode (SLD). The spectrum emitted by the SLD exhibits a full-width…

We report a computational 3D microscopy technique, termed Fourier ptychographic diffraction tomography (FPDT), that iteratively stitches together numerous variably illuminated, low-resolution images acquired with a low-numerical aperture…

Optics · Physics 2020-02-19 Chao Zuo , Jiasong Sun , Jiaji Li , Anand Asundi , Qian Chen

Optical coherence tomography angiography (OCTA) is a non-invasive imaging modality that can acquire high-resolution volumes of the retinal vasculature and aid the diagnosis of ocular, neurological and cardiac diseases. Segmenting the…

Optical coherence tomography (OCT) is being increasingly adopted as a label-free and non-invasive technique for biomedical applications such as cancer and ocular disease diagnosis. Diagnostic information for these tissues is manifest in…

We present spatial coherence measurements of partially coherent light in the far-field of incoherent sources with an experimental setup based on the Thompson-Wolf and Partanen-Turunen-Tervo experiments, to be performed in the context of a…

Instrumentation and Detectors · Physics 2021-05-05 Tiago E. C. Magalhães , José M. Rebordão , Alexandre Cabral

Optical coherence tomography (OCT) has stimulated a wide range of medical image-based diagnosis and treatment in fields such as cardiology and ophthalmology. Such applications can be further facilitated by deep learning-based…

Medical Physics · Physics 2023-07-24 Xueshen Li , Zhenxing Dong , Hongshan Liu , Jennifer J. Kang-Mieler , Yuye Ling , Yu Gan

Optical coherence tomography (OCT) is a prevalent non-invasive imaging method which provides high resolution volumetric visualization of retina. However, its inherent defect, the speckle noise, can seriously deteriorate the tissue…

Computer Vision and Pattern Recognition · Computer Science 2022-01-31 Dewei Hu , Yuankai K. Tao , Ipek Oguz

X-ray diffraction tomography (XDT) resolves spatially-variant XRD profiles within macroscopic objects, and provides improved material contrast compared to the conventional transmission-based computed tomography (CT). However, due to the…

Medical Physics · Physics 2019-01-04 Zheyuan Zhu , Alexander Katsevich , Shuo Pang

Due to its noninvasive character, optical coherence tomography (OCT) has become a popular diagnostic method in clinical settings. However, the low-coherence interferometric imaging procedure is inevitably contaminated by heavy speckle…

Image and Video Processing · Electrical Eng. & Systems 2020-07-08 Yongqiang Huang , Wenjun Xia , Zexin Lu , Yan Liu , Hu Chen , Jiliu Zhou , Leyuan Fang , Yi Zhang