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Recently, machine learning-based semantic segmentation algorithms have demonstrated their potential to accurately segment regions and contours in medical images, allowing the precise location of anatomical structures and abnormalities.…

Computer Vision and Pattern Recognition · Computer Science 2024-03-26 Yifei Wang , Chuhong Zhu

With the advent of digital scanners and deep learning, diagnostic operations may move from a microscope to a desktop. Hematoxylin and Eosin (H&E) staining is one of the most frequently used stains for disease analysis, diagnosis, and…

Computer Vision and Pattern Recognition · Computer Science 2023-08-28 Shikha Dubey , Tushar Kataria , Beatrice Knudsen , Shireen Y. Elhabian

Histopathological image analysis is an essential process for the discovery of diseases such as cancer. However, it is challenging to train CNN on whole slide images (WSIs) of gigapixel resolution considering the available memory capacity.…

Image and Video Processing · Electrical Eng. & Systems 2019-10-11 Shusuke Takahama , Yusuke Kurose , Yusuke Mukuta , Hiroyuki Abe , Masashi Fukayama , Akihiko Yoshizawa , Masanobu Kitagawa , Tatsuya Harada

Generative retrieval represents a novel approach to information retrieval. It uses an encoder-decoder architecture to directly produce relevant document identifiers (docids) for queries. While this method offers benefits, current approaches…

Information Retrieval · Computer Science 2024-09-30 Yubao Tang , Ruqing Zhang , Jiafeng Guo , Maarten de Rijke , Wei Chen , Xueqi Cheng

Deep learning is a powerful tool for whole slide image (WSI) analysis. Typically, when performing supervised deep learning, a WSI is divided into small patches, trained and the outcomes are aggregated to estimate disease grade. However,…

Computer Vision and Pattern Recognition · Computer Science 2022-05-20 Yi Zheng , Rushin H. Gindra , Emily J. Green , Eric J. Burks , Margrit Betke , Jennifer E. Beane , Vijaya B. Kolachalama

The evaluation of the Human Epidermal growth factor Receptor-2 (HER2) expression is an important prognostic biomarker for breast cancer treatment selection. However, HER2 scoring has notoriously high interobserver variability due to stain…

Image and Video Processing · Electrical Eng. & Systems 2022-11-18 Manh Dan Pham , Cyprien Tilmant , Stéphanie Petit , Isabelle Salmon , Saima Ben Hadj , Rutger H. J. Fick

The 7-point checklist (7PCL) is a widely used diagnostic tool in dermoscopy for identifying malignant melanoma by assigning point values to seven specific attributes. However, the traditional 7PCL is limited to distinguishing between…

Computer Vision and Pattern Recognition · Computer Science 2025-09-11 Yuheng Wang , Tianze Yu , Jiayue Cai , Sunil Kalia , Harvey Lui , Z. Jane Wang , Tim K. Lee

Medical generative models, acknowledged for their high-quality sample generation ability, have accelerated the fast growth of medical applications. However, recent works concentrate on separate medical generation models for distinct medical…

Image and Video Processing · Electrical Eng. & Systems 2024-03-08 Chenlu Zhan , Yu Lin , Gaoang Wang , Hongwei Wang , Jian Wu

Weakly supervised whole slide image classification is a key task in computational pathology, which involves predicting a slide-level label from a set of image patches constituting the slide. Constructing models to solve this task involves…

Glaucoma is a progressive optic neuropathy characterized by structural damage to the optic nerve head and functional changes in the visual field. Detecting glaucoma early is crucial to preventing loss of eyesight. However, medical datasets…

Image and Video Processing · Electrical Eng. & Systems 2024-12-09 Youssof Nawar , Nouran Soliman , Moustafa Wassel , Mohamed ElHabebe , Noha Adly , Marwan Torki , Ahmed Elmassry , Islam Ahmed

The morphology and distribution of microcalcifications in a cluster are the most important characteristics for radiologists to diagnose breast cancer. However, it is time-consuming and difficult for radiologists to identify these…

Computer Vision and Pattern Recognition · Computer Science 2021-05-17 Hao Du , Melissa Min-Szu Yao , Liangyu Chen , Wing P. Chan , Mengling Feng

The medical device industry has significantly advanced by integrating sophisticated electronics like microchips and field-programmable gate arrays (FPGAs) to enhance the safety and usability of life-saving devices. These complex…

Signal Processing · Electrical Eng. & Systems 2025-05-09 Binesh Sadanandan , Bahareh Arghavani Nobar , Vahid Behzadan

The opaque nature of deep learning models remains a significant barrier to their clinical adoption in medical imaging. This paper presents a multimodal explainability framework that bridges the gap between convolutional neural network (CNN)…

Computer Vision and Pattern Recognition · Computer Science 2026-05-08 Paul Valery Nguezet , Elie Tagne Fute , Yusuf Brima , Benoit Martin Azanguezet , Marcellin Atemkeng

With the rapid development of digital pathology, virtual staining has become a key technology in multimedia medical information systems, offering new possibilities for the analysis and diagnosis of pathological images. However, existing…

Computer Vision and Pattern Recognition · Computer Science 2025-06-10 Hao Yang , JianYu Wu , Run Fang , Xuelian Zhao , Yuan Ji , Zhiyu Chen , Guibin He , Junceng Guo , Yang Liu , Xinhua Zeng

Digital pathology and microscopy image analysis are widely employed in the segmentation of digitally scanned IHC slides, primarily to identify cancer and pinpoint regions of interest (ROI) indicative of tumor presence. However, current ROI…

Computer Vision and Pattern Recognition · Computer Science 2024-06-11 Akash Modi , Sumit Kumar Jha , Purnendu Mishra , Rajiv Kumar , Kiran Aatre , Gursewak Singh , Shubham Mathur

Advances in unsupervised learning of object-representations have culminated in the development of a broad range of methods for unsupervised object segmentation and interpretable object-centric scene generation. These methods, however, are…

Computer Vision and Pattern Recognition · Computer Science 2022-01-26 Martin Engelcke , Oiwi Parker Jones , Ingmar Posner

Osteoporosis is a common condition that increases fracture risk, especially in older adults. Early diagnosis is vital for preventing fractures, reducing treatment costs, and preserving mobility. However, healthcare providers face challenges…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Mehdi Hosseini Chagahi , Saeed Mohammadi Dashtaki , Niloufar Delfan , Nadia Mohammadi , Farshid Rostami Pouria , Behzad Moshiri , Md. Jalil Piran , Oliver Faust

Liquid-based cytology (LBC) is a reliable automated technique for the screening of Papanicolaou (Pap) smear data. It is an effective technique for collecting a majority of the cervical cells and aiding cytopathologists in locating abnormal…

Image and Video Processing · Electrical Eng. & Systems 2020-05-01 Sudhir Sornapudi , G. T. Brown , Zhiyun Xue , Rodney Long , Lisa Allen , Sameer Antani

Medical image-to-image (I2I) translation enables virtual scanning, i.e. the synthesis of a target imaging modality from a source one without additional acquisitions. Despite growing interest, most proposed methods operate on 2D slices, are…

Due to its superior efficiency in utilizing annotations and addressing gigapixel-sized images, multiple instance learning (MIL) has shown great promise as a framework for whole slide image (WSI) classification in digital pathology…

Quantitative Methods · Quantitative Biology 2023-07-14 Qiehe Sun , Jiawen Li , Jin Xu , Junru Cheng , Tian Guan , Yonghong He