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Developing and maintaining life requires a lot of computation. This is done by gene regulatory networks. But we have little understanding of how this computation is organized. I show that there is a direct correspondence between the…

Molecular Networks · Quantitative Biology 2022-09-01 Thomas M. A. Fink

Cooperation plays a key role in the evolution of complex systems. However, the level of cooperation extensively varies with the topology of agent networks in the widely used models of repeated games. Here we show that cooperation remains…

Molecular Networks · Quantitative Biology 2012-03-01 Shijun Wang , Mate S. Szalay , Changshui Zhang , Peter Csermely

Many data analysis problems rely on dynamic networks, such as social or communication network analyses. Providing a scalable overview of long sequences of such dynamic networks remains challenging due to the underlying large-scale data…

Social and Information Networks · Computer Science 2022-08-26 Eren Cakmak , Johannes Fuchs , Dominik Jäckle , Tobias Schreck , Ulrik Brandes , Daniel Keim

Deep learning algorithms demonstrate a surprising ability to learn high-dimensional tasks from limited examples. This is commonly attributed to the depth of neural networks, enabling them to build a hierarchy of abstract, low-dimensional…

Machine Learning · Computer Science 2024-07-04 Francesco Cagnetta , Leonardo Petrini , Umberto M. Tomasini , Alessandro Favero , Matthieu Wyart

Complex networks have recently attracted much interest due to their prevalence in nature and our daily lives [1, 2]. A critical property of a network is its resilience to random breakdown and failure [3-6], typically studied as a…

Physics and Society · Physics 2016-01-08 James P. Bagrow , Sune Lehmann , Yong-Yeol Ahn

Networks are fundamental building blocks for representing data, and computations. Remarkable progress in learning in structurally defined (shallow or deep) networks has recently been achieved. Here we introduce evolutionary exploratory…

Neural and Evolutionary Computing · Computer Science 2019-11-05 Rise Ooi , Chao-Han Huck Yang , Pin-Yu Chen , Vìctor Eguìluz , Narsis Kiani , Hector Zenil , David Gomez-Cabrero , Jesper Tegnèr

Activity in coupled systems is often oscillatory, for example, the firing pattern of neuronal populations. Whereas these oscillations have been studied predominantly in local circuits, here we show how the topology of large-scale networks,…

Neurons and Cognition · Quantitative Biology 2014-05-15 Marcus Kaiser

At rest, human brain functional networks display striking modular architecture in which coherent clusters of brain regions are activated. The modular account of brain function is pervasive, reliable, and reproducible. Yet, a complementary…

While heterophily has been widely studied in node-level tasks, its impact on graph-level tasks remains unclear. We present the first analysis of heterophily in graph-level learning, combining theoretical insights with empirical validation.…

Machine Learning · Computer Science 2025-09-24 Qinhan Hou , Yilun Zheng , Xichun Zhang , Sitao Luan , Jing Tang

Many real-world networks, including nervous systems, exhibit meso-scale structure. This means that their elements can be grouped into meaningful sub-networks. In general, these sub-networks are unknown ahead of time and must be "discovered"…

Neurons and Cognition · Quantitative Biology 2020-11-16 Richard F. Betzel

When a neural network can learn multiple distinct algorithms to solve a task, how does it "choose" between them during training? To approach this question, we take inspiration from ecology: when multiple species coexist, they eventually…

Machine Learning · Computer Science 2024-05-28 Xiaoman Delores Ding , Zifan Carl Guo , Eric J. Michaud , Ziming Liu , Max Tegmark

Complex networks often have a modular structure, where a number of tightly- connected groups of nodes (modules) have relatively few interconnections. Modularity had been shown to have an important effect on the evolution and stability of…

Physics and Society · Physics 2014-04-21 Saray Shai , Dror Y. Kenett , Yoed N. Kenett , Miriam Faust , Simon Dobson , Shlomo Havlin

In several applications, including in synthetic biology, one often has input/output data on a system composed of many modules, and although the modules' input/output functions and signals may be unknown, knowledge of the composition…

Machine Learning · Computer Science 2026-04-28 Jichi Wang , Eduardo D. Sontag , Domitilla Del Vecchio

Biological systems encode function not primarily in steady states, but in the structure of transient responses elicited by time-varying stimuli. Overshoots, biphasic dynamics, adaptation kinetics, fold-change detection, entrainment, and…

Quantitative Methods · Quantitative Biology 2026-01-05 Eduardo D. Sontag

Prediction tasks over nodes and edges in networks require careful effort in engineering features used by learning algorithms. Recent research in the broader field of representation learning has led to significant progress in automating…

Social and Information Networks · Computer Science 2016-07-05 Aditya Grover , Jure Leskovec

In this thesis, we have studied the large scale structure and system level dynamics of certain biological networks using tools from graph theory, computational biology and dynamical systems. We study the structure and dynamics of large…

Molecular Networks · Quantitative Biology 2008-12-31 Areejit Samal

Transferability of learned features between tasks can massively reduce the cost of training a neural network on a novel task. We investigate the effect of network width on learned features using activation atlases --- a visualization…

Machine Learning · Computer Science 2019-09-26 Dar Gilboa , Guy Gur-Ari

The optimal design of neural networks is a critical problem in many applications. Here, we investigate how dynamical systems with polynomial nonlinearities can inform the design of neural systems that seek to emulate them. We propose a…

Machine Learning · Computer Science 2021-06-23 Margaret Trautner , Ziwei Li , Sai Ravela

Naturally occurring networks exhibit quantitative features revealing underlying growth mechanisms. Numerous network mechanisms have recently been proposed to reproduce specific properties such as degree distributions or clustering…

Quantitative Methods · Quantitative Biology 2009-11-10 Manuel Middendorf , Etay Ziv , Chris Wiggins

The width of a neural network matters since increasing the width will necessarily increase the model capacity. However, the performance of a network does not improve linearly with the width and soon gets saturated. In this case, we argue…

Computer Vision and Pattern Recognition · Computer Science 2022-09-07 Shuai Zhao , Liguang Zhou , Wenxiao Wang , Deng Cai , Tin Lun Lam , Yangsheng Xu